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Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteins (TNFRSF11B)

The protein encoded by TNFRSF11B is a member of the TNF-receptor superfamily. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 11b Antibodies (96) and Tumor Necrosis Factor Receptor Superfamily, Member 11b Kits (66) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFRSF11B 4982 O00300
TNFRSF11B 25341 O08727
Mouse TNFRSF11B TNFRSF11B 18383 O08712
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Top Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$198.00
Details
HOST_Hi-5 Human His tag 30 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$225.75
Details
HOST_HEK-293 Human His tag   20 μg Log in to see 2 to 3 Days
$178.50
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$378.13
Details
HOST_HEK-293 Human Fc Tag   0.1 mg Log in to see 2 to 3 Days
$378.13
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 7 to 9 Days
$413.21
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,045.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,048.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   0.01 mg Log in to see 2 to 3 Days
$178.75
Details

TNFRSF11B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
,
Rat (Rattus)

Top referenced Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteins

  1. Human TNFRSF11B Protein expressed in HEK-293 Cells - ABIN2181847 : Tsuda, Goto, Mochizuki, Yano, Kobayashi, Morinaga, Higashio: Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. in Biochemical and biophysical research communications 1997 (PubMed)
    Show all 4 references for ABIN2181847

  2. Human TNFRSF11B Protein expressed in Hi-5 - ABIN666742 : Yasuda, Shima, Nakagawa, Yamaguchi, Kinosaki, Mochizuki, Tomoyasu, Yano, Goto, Murakami, Tsuda, Morinaga, Higashio, Udagawa, Takahashi, Suda: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 3 references for ABIN666742

More Proteins for Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Interaction Partners

Human Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. Alendronate stimulated OPG mRNA and protein expression, but not RANKL (show TNFSF11 Proteins) expression, in fibroblasts from patients with aseptic loosening following total hip arthroplasty.

  2. Single nucleotide polymorphisms (SNPs) rs1035798 in RAGE gene, rs2073617 and rs2073618 in TNFRSF11B, and rs3732410 in Golgb1 will be investigated on whether there is an association with hemorrhagic stroke (HS) in Chinese population.

  3. Hypoxia can affect the expression of RANKL (show TNFSF11 Proteins) and OPG in human periodontal ligament cells

  4. Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-kappaB Ligand (RANKL (show TNFSF11 Proteins)), is Dysregulated in BRCA Mutation Carriers

  5. expression of OPG, RANK and RANKL (show TNFSF11 Proteins) genes exert a crucial role in the progression of avascular necrosis

  6. Studies demonstrate that OPG induces proliferation, angiogenesis, aneuploidy and survival through manipulation of various survival and aneuploidy related kinases in human mammary epithelial cells spheres.

  7. Germline variation in TNFRSF11B gene is associated with the risk of multiple myeloma bone disease.

  8. the independent and positive (beta = 0.449, p = 0.004, and R(2) = 0.185) association between the OxS marker and RANKL/OPG (show TNFSF11 Proteins) ratio which was found in osteopenic but not in the other 2 sample groups.

  9. the rs3134069 polymorphism of TNFRSF11B seems to be the most likely protective genetic factor in chronic kidney disease development in patients with type 2 diabetes mellitus and diabetic foot

  10. expression of wild type GATA-3 (show GATA3 Proteins) activated OPG mRNA and protein expression, while the expression of a dominant negative mutant of GATA-3 (show GATA3 Proteins) or a GATA-3 (show GATA3 Proteins) shRNA construct reduced OPG mRNA and protein levels

Rabbit Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (show TNFSF11 Proteins) mRNA expression.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. OPG (show TNFSF11 Proteins) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

  2. the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice

  3. identify osteoprotegerin as a HIF target gene capable of directing osteoblast-mediated osteoclastogenesis to regulate bone homeostasis

  4. Osteoprotegerin is increased in metabolic syndrome and promotes adipose tissue proinflammatory changes.

  5. Osteoprotegerin inhibits vascular calcification by regulating the procalcific effects of RANKL (show TNFSF11 Proteins) and Il6 (show IL6 Proteins) on vascular smooth muscle cells.

  6. These results indicate that OPG (show TNFSF11 Proteins) derived either from the bone marrow or from the vessel wall is sufficient to slow down lesion progression and vascular calcification independent of bone turnover.

  7. High concentrations of alendronate decrease the expressions of OPG (show TNFSF11 Proteins) and RANKL (show TNFSF11 Proteins) in cultured osteoblasts.

  8. In a xenograft model, increased osteoprotegerin expression correlated with a delay to pathologic fracture suggesting a potential role for mTOR (show FRAP1 Proteins) inhibitors in the treatment of neuroblastoma (show ARHGEF16 Proteins) bone metastases.

  9. Data indicate in TLR4 (show TLR4 Proteins)(-/-) mice, higher expression levels of IL-1beta (show IL1B Proteins) and lower expression levels of VEGF (show VEGFA Proteins), RANK, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) were detected at late time points (> postoperative 4 days).

  10. Coptisine inhibits RANKL (show TNFSF11 Proteins)-induced NF-kappaB (show NFKB1 Proteins) phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) gene expression in osteoblastic cells.

Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Gene names and symbols associated with TNFRSF11B

  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • tumor necrosis factor receptor superfamily, member 11b (tnfrsf11b)
  • osteoprotegerin (LOC100037695)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (Tnfrsf11b)
  • OCIF protein
  • Opg protein
  • TR1 protein

Protein level used designations for TNFRSF11B

osteoprotegerin , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) , Osteoprotegerin , tumor necrosis factor receptor superfamily, member 11b , tumor necrosis factor receptor superfamily member 11B-like , osteoclastogenesis inhibitory factor , tumor necrosis factor receptor superfamily member 11B

GENE ID SPECIES
464351 Pan troglodytes
444716 Xenopus laevis
482025 Canis lupus familiaris
701850 Macaca mulatta
100399751 Callithrix jacchus
100433420 Pongo abelii
100465761 Ailuropoda melanoleuca
100599407 Nomascus leucogenys
100037695 Ovis aries
4982 Homo sapiens
100348133 Oryctolagus cuniculus
25341 Rattus norvegicus
100860896 Capra hircus
100049688 Sus scrofa
523822 Bos taurus
100065885 Equus caballus
18383 Mus musculus
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