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The protein encoded by TNFRSF11B is a member of the TNF-receptor superfamily. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 11b Antibodies (97) and Tumor Necrosis Factor Receptor Superfamily, Member 11b Kits (66) and many more products for this protein.
Showing 10 out of 31 products:
Human TNFRSF11B Protein expressed in HEK-293 Cells - ABIN2181847
Tsuda, Goto, Mochizuki, Yano, Kobayashi, Morinaga, Higashio: Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. in Biochemical and biophysical research communications 1997
Show all 4 references for ABIN2181847
Human TNFRSF11B Protein expressed in Hi-5 - ABIN666742
Yasuda, Shima, Nakagawa, Yamaguchi, Kinosaki, Mochizuki, Tomoyasu, Yano, Goto, Murakami, Tsuda, Morinaga, Higashio, Udagawa, Takahashi, Suda: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 3 references for ABIN666742
Studies demonstrate that OPG induces proliferation, angiogenesis, aneuploidy and survival through manipulation of various survival and aneuploidy related kinases in human mammary epithelial cells spheres.
Germline variation in TNFRSF11B gene is associated with the risk of multiple myeloma bone disease.
the independent and positive (beta = 0.449, p = 0.004, and R(2) = 0.185) association between the OxS marker and RANKL/OPG (show TNFSF11 Proteins) ratio which was found in osteopenic but not in the other 2 sample groups.
the rs3134069 polymorphism of TNFRSF11B seems to be the most likely protective genetic factor in chronic kidney disease development in patients with type 2 diabetes mellitus and diabetic foot
expression of wild type GATA-3 (show GATA3 Proteins) activated OPG mRNA and protein expression, while the expression of a dominant negative mutant of GATA-3 (show GATA3 Proteins) or a GATA-3 (show GATA3 Proteins) shRNA construct reduced OPG mRNA and protein levels
Despite comparable osteoprotegerin concentrations, lumbar disc herniation cases express lower RANKL (show TNFSF11 Proteins) than controls. Disc herniation was strongly associated with RANKL (show TNFSF11 Proteins) and the presence of the F allele of the VDR (show CYP27B1 Proteins) gene.
OPG and TRAIL are associated with the underlying cardiovascular damage in atrial fibrillation, but their balance is modulated by the fact of sinus rhythm restoration.
serum OPG is independently associated with pulse pressure in kidney transplant recipients.
Transglutaminase 2 (show TGM2 Proteins) up-regulation is associated with RANKL/OPG (show TNFSF11 Proteins) pathway
OPG level did not vary significantly between patients with hypertension, hypertension and T2DM, or healthy controls.
Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (show TNFSF11 Proteins) mRNA expression.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.
OPG (show TNFSF11 Proteins) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice
identify osteoprotegerin as a HIF target gene capable of directing osteoblast-mediated osteoclastogenesis to regulate bone homeostasis
Osteoprotegerin is increased in metabolic syndrome and promotes adipose tissue proinflammatory changes.
Osteoprotegerin inhibits vascular calcification by regulating the procalcific effects of RANKL (show TNFSF11 Proteins) and Il6 (show IL6 Proteins) on vascular smooth muscle cells.
These results indicate that OPG (show TNFSF11 Proteins) derived either from the bone marrow or from the vessel wall is sufficient to slow down lesion progression and vascular calcification independent of bone turnover.
High concentrations of alendronate decrease the expressions of OPG (show TNFSF11 Proteins) and RANKL (show TNFSF11 Proteins) in cultured osteoblasts.
In a xenograft model, increased osteoprotegerin expression correlated with a delay to pathologic fracture suggesting a potential role for mTOR (show FRAP1 Proteins) inhibitors in the treatment of neuroblastoma (show ARHGEF16 Proteins) bone metastases.
Data indicate in TLR4 (show TLR4 Proteins)(-/-) mice, higher expression levels of IL-1beta (show IL1B Proteins) and lower expression levels of VEGF (show VEGFA Proteins), RANK, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) were detected at late time points (> postoperative 4 days).
Coptisine inhibits RANKL (show TNFSF11 Proteins)-induced NF-kappaB (show NFKB1 Proteins) phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) gene expression in osteoblastic cells.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, tumor necrosis factor receptor superfamily, member 11b
, tumor necrosis factor receptor superfamily member 11B-like
, osteoclastogenesis inhibitory factor
, tumor necrosis factor receptor superfamily member 11B