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The protein encoded by TNFRSF13B is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. Additionally we are shipping TNFRSF13B Proteins (23) and TNFRSF13B Kits (21) and many more products for this protein.
Showing 10 out of 174 products:
Human Monoclonal TNFRSF13B Primary Antibody for FACS - ABIN4896092
Tai, Li, Breitkreutz, Song, Neri, Catley, Podar, Hideshima, Chauhan, Raje, Schlossman, Richardson, Munshi, Anderson: Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. in Cancer research 2006
Show all 5 Pubmed References
Mouse (Murine) Monoclonal TNFRSF13B Primary Antibody for FACS - ABIN4897628
Uslu, Coleman, Allman, Katsenelson, Bram, Alugupalli, Akkoyunlu: Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-linked immunodeficient mice. in Journal of immunology (Baltimore, Md. : 1950) 2014
Show all 4 Pubmed References
Human Polyclonal TNFRSF13B Primary Antibody for WB - ABIN2668579
Sakurai, Hase, Kanno, Kojima, Okumura, Kobata: TACI regulates IgA production by APRIL in collaboration with HSPG. in Blood 2007
Mouse (Murine) Monoclonal TNFRSF13B Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900394
Matsumoto, Kobata, Odaka, Furukawa, Hirata, Yuki: BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide. in Journal of neuroimmunology 2010
BAFF (show TNFSF13B Antibodies)-induced processing of BAFFR (show TNFRSF13C Antibodies) regulates BAFF (show TNFSF13B Antibodies)-mediated B cell responses in a TACI-dependent manner.
results suggest that TACI A181E heterozygosity results in TACI haploinsufficiency with increased susceptibility to pneumococcal infection
The expression levels of serum BAFF (show TNFSF13B Antibodies) and the three receptors (TACI, BCMA (show TNFRSF17 Antibodies) and BAFF-R (show TNFRSF13C Antibodies)) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.
11% of common variable immunodeficiency patients and 13% of antibody deficiency syndromes patients carried at least one mutated TNFRSF13B allele.
SNPs rs9514828 (BAFF (show TNFSF13B Antibodies)), rs3803800 (APRIL) and rs4985726 (TACI) may be associated with the risk of development of B-cell chronic lymphocytic leukemia in a Polish population.
serum levels not associated with disease activity in MPO (show MPO Antibodies)-ANCA-associated renal vasculitis
In this review, we aim at giving an insight into the genetics underlying the CVID and particularly at outlining the role of TACI and its relative contribution to the development of CVID-like phenotypes in human.
TNFRSF13B hemizygosity does not recapitulate autoimmune features of common variable immune deficiency -associated C104R and A181E TNFRSF13B mutations, which likely encode dominant negative products, but instead reveals selective TACI haploinsufficiency at later stages of B-cell development.
Common variable immune d (show TNFSF13B Antibodies)eficiency patients with heterozygous mutations in TACI alleles increase susceptibility to autoimmune diseases.
The study demonstrated that there is a remarkable interindividual variability of TACI expression in chronic lymphocytic leukemia, although the majority of patients display low to undetectable TACI.
findings highlight a novel mechanism through which BAFF (show TNFSF13B Antibodies) promotes humoral autoimmunity via direct, TACI-dependent activation of transitional B cells
this study shows that increased TACI expression in B cells derived from non-obese diabetic mice contributes to the pathogenesis of type 1 diabetes NOD mice
splenic B cells from TACI-deficient (TACI- / -) mice were unable to secrete IL-10 (show IL10 Antibodies) following TLR stimulation, and TACI- / - mice had undetectable basal serum concentrations of IL-10 (show IL10 Antibodies).
Data show that production of autoantibodies in B cell-activating factor (show TNFSF13B Antibodies) of the TNF (show TNF Antibodies) family (BAFF (show TNFSF13B Antibodies)) is dependent on tumor necrosis factor (show TNF Antibodies) receptor superfamily, member 13b protein (TACI) expression by B cells.
Taci (-/-) mice and BAFF (show TNFSF13B Antibodies) transgenic mice both develop signs of human Systemic Lupus Erythematosus.
Elimination of B lymphocyte stimulator (show TNFSF13B Antibodies) receptor 3 (BR-3) and TACI inhibits the development of SLE in NZM mice.
TACI deficiency has a role in alternatively activated macrophage phenotype and susceptibility to Leishmania infection
Heteromers consisting of one BAFF (show TNFSF13B Antibodies) and two APRIL bind to receptor TACI, BCMA (show TNFRSF17 Antibodies) but not to BAFFR (show TNFRSF13C Antibodies).
Mice lacking TACI are able to clear Citrobacter rodentium, a model pathogen for severe human enteritis, more rapidly than did wild type mice.
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
transmembrane activator and CAML interactor
, tumor necrosis factor receptor 13B
, tumor necrosis factor receptor superfamily member 13B
, tumor necrosis factor receptor superfamily, member 13B
, transmembrane activator and calcium-modulating and cyclophilin ligand interactor