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Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteins (TNFRSF4)

The protein encoded by TNFRSF4 is a member of the TNF-receptor superfamily. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 4 Antibodies (210) and Tumor Necrosis Factor Receptor Superfamily, Member 4 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFRSF4 22163 P47741
TNFRSF4 7293 P43489
TNFRSF4 25572 P15725
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Top Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteins at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$308.00
Details
HOST_Human Cells Human His tag,Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Human His tag 10 μg Log in to see 2 to 3 Days
$262.50
Details
HOST_Human Human Fc Tag   50 μg Log in to see 5 to 8 Days
$351.75
Details
HOST_HEK-293 Cells Human Fc Tag   10 μg Log in to see 2 to 3 Days
$157.50
Details

TNFRSF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , , , ,
, ,
Human , , , , , ,
, , , , ,
Rat (Rattus)

Top referenced Tumor Necrosis Factor Receptor Superfamily, Member 4 Proteins

  1. Human TNFRSF4 Protein expressed in HEK-293 Cells - ABIN2181573 : Arch, Thompson: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. in Molecular and cellular biology 1998 (PubMed)
    Show all 2 references for ABIN2181573

  2. Mouse (Murine) TNFRSF4 Protein expressed in Human Cells - ABIN2008326 : Chen, McAdam, Buhlmann, Scott, Lupher, Greenfield, Baum, Fanslow, Calderhead, Freeman, Sharpe: Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. in Immunity 2000 (PubMed)
    Show all 2 references for ABIN2008326

  3. Human TNFRSF4 Protein expressed in Human Cells - ABIN2002937 : Calderhead, Buhlmann, van den Eertwegh, Claassen, Noelle, Fell: Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. in Journal of immunology (Baltimore, Md. : 1950) 1993 (PubMed)
    Show all 2 references for ABIN2002937

More Proteins for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Interaction Partners

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) interaction partners

  1. Crystal structures and NMR data show that the Roquin-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR with identical binding modes.

  2. The OX40-OX40 ligand (show TNFSF4 Proteins) interaction up-regulates intracellular levels of reactive oxygen species in atherogenesis.

  3. OX40 was highly expressed by intratumoral T cells, particularly those of the FoxP3 (show FOXP3 Proteins)(+) regulatory T-cell (Treg) lineage.

  4. OX40 and IL-7 (show IL7 Proteins) play synergistic, but distinct roles in the homeostatic proliferation of CD4 (show CD4 Proteins)(+) effector memory T cells

  5. OX40-OX40L (show TNFSF4 Proteins) interaction regulates the expression of NFATc1 (show NFATC1 Proteins), which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis.

  6. During CD134 plus CD137 (show TNFRSF9 Proteins) dual costimulation, IFN-gamma (show IFNG Proteins) interacts with IL-2 (show IL2 Proteins) through distinct mechanisms to program maximal expression of effector molecules in antigen-responding T-cells.

  7. OX40 stimulation of virus-specific CD4 (show CD4 Proteins) T cells promoted expression of the transcriptional repressor Blimp-1 (show PRDM1 Proteins) and diverted the majority of cells away from follicular Th cell differentiation.

  8. interruption of the OX40-OX40L signaling pathway, with decreases in dietary cholesterol, induces regression of atherosclerosis by induction of IL-5-producing T cells and oxidized low-density lipoprotein-specific IgM and reductions in Th2 and mast cells.

  9. OX40-OX40L (show TNFSF4 Proteins) interaction promotes proliferation and activation of lymphocytes via NFATc1 (show NFATC1 Proteins) in ApoE (show APOE Proteins)-deficient mice.

  10. These data show that OX40-OX40L (show TNFSF4 Proteins) signaling contributes to the evolution of the adaptive immune response to an allograft via the differential control of alloreactive effector and regulatory T cell survival.

Human Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) interaction partners

  1. Low OX40 expression is associated with colorectal cancer.

  2. OX40 and its ligand are co stimulators for T lymphocytes.

  3. These studies provide the first direct evidence that ligation of tumour necrosis factor (show TNF Proteins) superfamily members and their cognate receptors is important for the control of viral lytic replication.

  4. Malaria patients and Plasmodium-infected rodents exhibit enhanced expression of the co-stimulatory receptor OX40 on CD4 (show CD4 Proteins) T cells, which is abrogated following coordinate PD-1 (show PDCD1 Proteins) co-inhibitory pathways, which are also upregulated during malaria.

  5. Identified two key amino acid residues within CD134 that are required for its interaction with herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to CD134.

  6. TL1A (show TNFSF15 Proteins) increases expression of CD25 (show IL2RA Proteins), LFA-1 (show ITGAL Proteins), CD134 and CD154 (show CD40LG Proteins), and induces IL-22 (show IL22 Proteins) and GM-CSF (show CSF2 Proteins) production from effector CD4 (show CD4 Proteins) T-cells

  7. Data indicate that soluble OX40 and sOX40L plasma levels are increased in early rheumatoid arthritis patients.

  8. High expression of OX40 is associated with type 1 diabetes.

  9. A cysteine-rich domain of CD134 that is critical for binding to the HHV-6B glycoprotein gH/gL/gQ1/gQ2 complex and HHV-6B infection.

  10. cirrhotic and hepatocellular carcinoma fragments moderately and highly infiltrated by Tregs, respectively, expressing OX40

Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

Gene names and symbols associated with TNFRSF4

  • tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)
  • tumor necrosis factor receptor superfamily, member 4 (Tnfrsf4)
  • ACT35 protein
  • CD134 protein
  • Ly-70 protein
  • OX40 protein
  • TNFRSF4 protein
  • Txgp1 protein
  • TXGP1L protein

Protein level used designations for TNFRSF4

tumor necrosis factor receptor superfamily, member 4 , tumor necrosis factor receptor superfamily member 4 , OX40 antigen , OX40L receptor , tax-transcriptionally activated glycoprotein 1 , ACT35 antigen , ATC35 antigen , CD134 antigen , OX40 cell surface antigen , OX40 homologue , TAX transcriptionally-activated glycoprotein 1 receptor , lymphoid activation antigene ACT35 , tax-transcriptionally activated glycoprotein 1 receptor , MRC OX40 , Tax-transcriptionally activated glycoprotein 1 , tumor necrosis factor (ligand) superfamily member 4 , tumor necrosis factor superfamily, member 4

GENE ID SPECIES
457185 Pan troglodytes
489600 Canis lupus familiaris
528782 Bos taurus
699674 Macaca mulatta
22163 Mus musculus
493665 Felis catus
7293 Homo sapiens
25572 Rattus norvegicus
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