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Tumor Protein P53 Binding Protein 2 Proteins (TP53BP2)

TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. Additionally we are shipping Tumor Protein P53 Binding Protein 2 Antibodies (63) and Tumor Protein P53 Binding Protein 2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TP53BP2 21981 Q62415
TP53BP2 7159 Q13625
Rat TP53BP2 TP53BP2 305025  
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Top Tumor Protein P53 Binding Protein 2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

TP53BP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Tumor Protein P53 Binding Protein 2 (TP53BP2) Interaction Partners

Zebrafish Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.

Mouse (Murine) Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. After genotoxic stress, Aspp1 (show PPP1R13B Proteins) promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) cycling and induces p53 (show TP53 Proteins)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 (show PPP1R13B Proteins) also attenuates HSC (show FUT1 Proteins) self-renewal and accumulation of DNA damage in p53 (show TP53 Proteins) null HSCs.

  2. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  3. ASPP2 prevents beta-catenin (show CTNNB1 Proteins) from transactivating ZEB1 directly by forming an ASPP2-beta-catenin (show CTNNB1 Proteins)-E-cadherin (show CDH1 Proteins) ternary complex

  4. findings suggest that the identified STAT1 (show STAT1 Proteins)/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation

  5. our studies demonstrate the role of Siah2 (show SIAH2 Proteins) in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.

  6. ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB (show NFKB1 Proteins)-mediated repression of p63 (show CKAP4 Proteins).

  7. Our study demonstrates a novel role for ASPP1 (show PPP1R13B Proteins) and ASPP2 in the death of retinal ganglion cells.

  8. regulates epithelial cell polarity in cooperation with PAR-3 (show F2RL2 Proteins) to form an active PAR (show AFG3L2 Proteins) complex

  9. Consistent with its role in cell polarity, ASPP2 influences interkinetic nuclear migration and lamination during CNS development.

  10. Aspp1 (show PPP1R13B Proteins) plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53 (show TP53 Proteins)-independent manner.

Human Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. miR (show MLXIP Proteins)-548d-3p/TP53BP2 pathway is critically involved in the proliferation and apoptosis of breast cancer cells and may be new therapeutic target of breast cancer cells.

  2. ASPP1 (show PPP1R13B Proteins)/2-PP1 (show PPA1 Proteins) complexes are required for chromosome segregation and kinetochore-microtubule attachments.

  3. ASSP2 expression is lower in cancerous tissues and decreased ASPP2 lead to higher cancer cells proliferation and autophagic flux, which contribute to the gemcitabine resistance.

  4. this study revealed a novel function of ASPP2 in modulating autophagy and apoptosis.

  5. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  6. These results identify previously uncharacterized regions distributed throughout the protein sequence of ASPP2 as determinants of CagA (show S100A8 Proteins) binding, providing mechanistic insight into apoptosis reprogramming by CagA (show S100A8 Proteins).

  7. ASPP2 directly induces the dephosphorylation and activation of junctional YAP (show YAP1 Proteins)

  8. CHOP (show DDIT3 Proteins) is critical for mediating ASPP2-induced autophagic apoptosis by decreasing Bcl-2 (show BCL2 Proteins) expression and maintaining nuclear ASPP2-Bcl-2 (show BCL2 Proteins) complexes.

  9. ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis.

  10. these observations reveal that Itch and Yap1 (show YAP1 Proteins) have antagonistic roles in the regulation of ASPP2 protein stability through competing post-translational regulatory mechanism of ASPP2.

Tumor Protein P53 Binding Protein 2 (TP53BP2) Protein Profile

Protein Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TP53BP2

  • tumor protein p53 binding protein, 2 (TP53BP2)
  • tumor protein p53 binding protein, 2 (tp53bp2)
  • si:dkeyp-34c12.2 (si:dkeyp-34c12.2)
  • protein phosphatase 1, regulatory (inhibitor) subunit 13B (Ppp1r13b)
  • transformation related protein 53 binding protein 2 (Trp53bp2)
  • tumor protein p53 binding protein, 2 (Tp53bp2)
  • 53BP2 protein
  • AI449786 protein
  • AI746547 protein
  • ASPP1 protein
  • ASPP2 protein
  • AW545810 protein
  • BBP protein
  • P53BP2 protein
  • p85 protein
  • PPP1R13A protein
  • Tp53bp2 protein
  • Trp53bp2 protein
  • wu:fa09h08 protein
  • wu:fb04e08 protein
  • X98550 protein
  • zgc:85720 protein

Protein level used designations for TP53BP2

tumor protein p53 binding protein, 2 , apoptosis-stimulating of p53 protein 2-like , apoptosis-stimulating of p53 protein 1 , protein phosphatase 1 regulatory subunit 13B , transformation related protein 53 binding protein 2 , tumor protein p53-binding protein, 2 , apoptosis-stimulating of p53 protein 2 , p53-binding protein 2 , p53BP2 , tumor suppressor p53-binding protein 2 , fb04e08 , BCL2-binding protein , apoptosis-stimulating protein of p53, 2 , renal carcinoma antigen NY-REN-51

GENE ID SPECIES
421329 Gallus gallus
457766 Pan troglodytes
548790 Xenopus (Silurana) tropicalis
568138 Danio rerio
705383 Macaca mulatta
100055278 Equus caballus
100221962 Taeniopygia guttata
100445132 Pongo abelii
100519863 Sus scrofa
21981 Mus musculus
209456 Mus musculus
407983 Danio rerio
446947 Xenopus laevis
7159 Homo sapiens
490397 Canis lupus familiaris
514474 Bos taurus
305025 Rattus norvegicus
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