Tumor Protein P53 Binding Protein 2 Proteins (TP53BP2)

TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. Additionally we are shipping Tumor Protein P53 Binding Protein 2 Antibodies (71) and Tumor Protein P53 Binding Protein 2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TP53BP2 21981 Q62415
TP53BP2 7159 Q13625
Rat TP53BP2 TP53BP2 305025  
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Top Tumor Protein P53 Binding Protein 2 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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TP53BP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Tumor Protein P53 Binding Protein 2 (TP53BP2) Interaction Partners

Zebrafish Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.

Mouse (Murine) Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. SPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  2. After genotoxic stress, Aspp1 (show PPP1R13B Proteins) promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) cycling and induces p53 (show TP53 Proteins)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 (show PPP1R13B Proteins) also attenuates HSC (show FUT1 Proteins) self-renewal and accumulation of DNA damage in p53 (show TP53 Proteins) null HSCs.

  3. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  4. ASPP2 prevents beta-catenin (show CTNNB1 Proteins) from transactivating ZEB1 directly by forming an ASPP2-beta-catenin (show CTNNB1 Proteins)-E-cadherin (show CDH1 Proteins) ternary complex

  5. findings suggest that the identified STAT1 (show STAT1 Proteins)/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation

  6. our studies demonstrate the role of Siah2 (show SIAH2 Proteins) in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.

  7. ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB (show NFKB1 Proteins)-mediated repression of p63 (show CKAP4 Proteins).

  8. Our study demonstrates a novel role for ASPP1 (show PPP1R13B Proteins) and ASPP2 in the death of retinal ganglion cells.

  9. regulates epithelial cell polarity in cooperation with PAR-3 (show F2RL2 Proteins) to form an active PAR (show AFG3L2 Proteins) complex

  10. Consistent with its role in cell polarity, ASPP2 influences interkinetic nuclear migration and lamination during CNS development.

Human Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These data together implicated a critical impact of MiR (show MLXIP Proteins)-205/ASPP2 on promoting epithelial-mesenchymal transition.

  2. ASPP2 is a key regulator of BECN1 (show BECN1 Proteins)-dependent autophagy.

  3. ASPP2 suppresses invasion, peritoneal dissemination and TGF-beta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins) by inhibiting Smad7 (show SMAD7 Proteins) degradation mediated by ITCH in gastric cancer cells.

  4. Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  5. ASPP2 suppresses p53 (show TP53 Proteins) target gene transactivation, promoter occupancy, and endogenous p53 (show TP53 Proteins) target gene expression in response to DNA damage

  6. In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin (show AREG Proteins) expression in a p53 (show TP53 Proteins)-dependent manner

  7. Downregulated expression of ASPP2 is associated with hepatocellular carcinoma.

  8. miR (show MLXIP Proteins)-548d-3p/TP53BP2 pathway is critically involved in the proliferation and apoptosis of breast cancer cells and may be new therapeutic target of breast cancer cells.

  9. ASPP1 (show PPP1R13B Proteins)/2-PP1 (show PPA1 Proteins) complexes are required for chromosome segregation and kinetochore-microtubule attachments.

  10. ASSP2 expression is lower in cancerous tissues and decreased ASPP2 lead to higher cancer cells proliferation and autophagic flux, which contribute to the gemcitabine resistance.

Tumor Protein P53 Binding Protein 2 (TP53BP2) Protein Profile

Protein Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TP53BP2

  • tumor protein p53 binding protein, 2 (TP53BP2)
  • tumor protein p53 binding protein, 2 (tp53bp2)
  • si:dkeyp-34c12.2 (si:dkeyp-34c12.2)
  • protein phosphatase 1, regulatory (inhibitor) subunit 13B (Ppp1r13b)
  • transformation related protein 53 binding protein 2 (Trp53bp2)
  • tumor protein p53 binding protein, 2 (Tp53bp2)
  • 53BP2 protein
  • AI449786 protein
  • AI746547 protein
  • ASPP1 protein
  • ASPP2 protein
  • AW545810 protein
  • BBP protein
  • P53BP2 protein
  • p85 protein
  • PPP1R13A protein
  • Tp53bp2 protein
  • Trp53bp2 protein
  • wu:fa09h08 protein
  • wu:fb04e08 protein
  • X98550 protein
  • zgc:85720 protein

Protein level used designations for TP53BP2

tumor protein p53 binding protein, 2 , apoptosis-stimulating of p53 protein 2-like , apoptosis-stimulating of p53 protein 1 , protein phosphatase 1 regulatory subunit 13B , transformation related protein 53 binding protein 2 , tumor protein p53-binding protein, 2 , apoptosis-stimulating of p53 protein 2 , p53-binding protein 2 , p53BP2 , tumor suppressor p53-binding protein 2 , fb04e08 , BCL2-binding protein , apoptosis-stimulating protein of p53, 2 , renal carcinoma antigen NY-REN-51

GENE ID SPECIES
421329 Gallus gallus
457766 Pan troglodytes
548790 Xenopus (Silurana) tropicalis
568138 Danio rerio
705383 Macaca mulatta
100055278 Equus caballus
100221962 Taeniopygia guttata
100445132 Pongo abelii
100519863 Sus scrofa
21981 Mus musculus
209456 Mus musculus
407983 Danio rerio
446947 Xenopus laevis
7159 Homo sapiens
490397 Canis lupus familiaris
514474 Bos taurus
305025 Rattus norvegicus
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