Tumor Susceptibility Gene 101 Proteins (TSG101)

The protein encoded by TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. Additionally we are shipping TSG101 Antibodies (117) and TSG101 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSG101 7251 Q99816
TSG101 22088 Q61187
Rat TSG101 TSG101 292925 Q6IRE4
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Top TSG101 Proteins at antibodies-online.com

Showing 9 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 25 to 30 Days
Human Un-conjugated   2 μg Log in to see 6 Days

TSG101 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced TSG101 Proteins

  1. Human TSG101 Protein expressed in Escherichia coli (E. coli) - ABIN667780 : Popov, Popova, Inoue, Göttlinger: Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production. in Journal of virology 2009 (PubMed)
    Show all 2 references for 667780

More Proteins for Tumor Susceptibility Gene 101 (TSG101) Interaction Partners

Fruit Fly (Drosophila melanogaster) Tumor Susceptibility Gene 101 (TSG101) interaction partners

  1. loss of ept alters nuclear cell cycle control in developing imaginal discs and the DaPKC, presenilin, and rbf1 genes as modifiers of molecular and cellular phenotypes that result from loss of ept

  2. analysis of genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor

Human Tumor Susceptibility Gene 101 (TSG101) interaction partners

  1. Results indicate that Vpr overcomes the effects of TSG101 overexpression to support viral production by competing with TSG101 to bind Gag.

  2. our studies reveal that Tsg101 plays a role in the trafficking of macropinocytosed Kaposi's sarcoma-associated herpesvirus in the endothelial cells

  3. Knockdown of LAMP2A, a CMA-related protein, and TSG101, an mA-related protein, significantly but only partially decreased the punctate accumulation of GAPDH (show GAPDH Proteins)-HT in AD293 cells and primary cultured rat cortical neurons.

  4. the variant alleles of TSG101 rs2292179 and ATF2 (show ATF2 Proteins) rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively

  5. TSGDelta154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation.

  6. Results show that TSG101 bidirectionally modulates cell invasion through regulating MMP-9 (show MMP9 Proteins) mRNA expression in different cell types.

  7. TSG101 plays an important role in the development of hepatocellular carcinoma

  8. Expression of tsg101 mRNA and of TSG101 protein were significantly higher in the oxaliplatin resistant cell line than parent HT-29 cels.

  9. PSAP (show PSAP Proteins) motif of OFR3 is required for hepatitis E virus exit and interaction with host TSG101.

  10. Stress-internalized EGFR (show EGFR Proteins) is retained intracellularly by continued p38 (show CRK Proteins) activity in a mechanism involving ubiquitin-independent, ESCRT/ALIX (show PDCD6IP Proteins)-dependent incorporation onto intraluminal vesicles (ILVs (show IARS Proteins)) of MVBs

Mouse (Murine) Tumor Susceptibility Gene 101 (TSG101) interaction partners

  1. Tsg101 was deleted from mature oligodendroglia in vivo. This resulted in severe spongiform encephalopathy, histopathologically similar to that observed in Mgrn1 (show MGRN1 Proteins) null mutant mice but with a more rapid onset.

  2. BLOS1 (show BLOC1S1 Proteins) interacts with sorting nexin 2 (show SNX2 Proteins) and the ESCRT-I (show VPS28 Proteins) component TSG101 to mediate the sorting of EGFR (show EGFR Proteins) into endosomal compartments

  3. pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4.

  4. Tsg101 has a role in expression of EGFR (show EGFR Proteins) and ErbB2 (show ERBB2 Proteins) and preventing induction of autophagy prior to cell death

  5. show that ubiquitin recognition by TSG101 is required for cSMAC formation, T cell receptor (TCR) microcluster signal termination, TCR downregulation.

  6. Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1 (show CDKN1A Proteins)).

  7. Targeted deletion results in cell cycle arrest and p53 (show TP53 Proteins)-independent cell death

  8. our results suggest that Tsg101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer.

  9. the TSG101 interaction with HRS is a crucial step in endocytic down-regulation of mitogenic signaling and this interaction may have a role in linking the functions of early and late endosomes

  10. the Tsg101 protein has only weak oncogenic properties

TSG101 Protein Profile

Protein Summary

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

Gene names and symbols associated with TSG101

  • tumor susceptibility gene 101 (TSG101)
  • tumor suppressor protein 101 (TSG101)
  • Tumor Susceptibility Gene homolog (tsg-101)
  • tumor susceptibility gene 101 (tsg101)
  • tumor susceptibility 101 (TSG101)
  • tumor susceptibility gene 101 (Tsg101)
  • AI255943 protein
  • burs protein
  • CC2 protein
  • CG9712 protein
  • Dmel\\CG9712 protein
  • DmTSG101 protein
  • dTsg101 protein
  • dVps23 protein
  • ept protein
  • ESCRT-I protein
  • MGC76193 protein
  • Rw protein
  • TSG10 protein
  • TSG101 protein
  • VPS23 protein
  • zgc:86926 protein

Protein level used designations for TSG101

CG9712-PA , TSG101-PA , erupted , tumor susceptibility Gene-101 , Tumor Susceptibility Gene homolog family member (tsg-101) , ESCRT-I complex subunit TSG101 , tumor susceptibility gene 101 protein , tumor susceptibility protein 101 , tumor susceptibility gene 101 , tumor susceptibility gene 10 , tumor susceptibility protein , Tumor supressor

100057099 Equus caballus
39881 Drosophila melanogaster
182474 Caenorhabditis elegans
693787 Macaca mulatta
451065 Pan troglodytes
394879 Xenopus (Silurana) tropicalis
100172234 Pongo abelii
7251 Homo sapiens
22088 Mus musculus
423082 Gallus gallus
485406 Canis lupus familiaris
507659 Bos taurus
292925 Rattus norvegicus
415179 Danio rerio
446571 Xenopus laevis
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