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This intronless gene encodes a carcinoma-associated antigen. Additionally we are shipping TACSTD2 Proteins (20) and TACSTD2 Kits (2) and many more products for this protein.
Showing 10 out of 160 products:
Human Polyclonal TACSTD2 Primary Antibody for FACS, IHC - ABIN4900496
Ambrogi, Fornili, Boracchi, Trerotola, Relli, Simeone, La Sorda, Lattanzio, Querzoli, Pedriali, Piantelli, Biganzoli, Alberti: Trop-2 is a determinant of breast cancer survival. in PLoS ONE 2014
Show all 8 references for ABIN4900496
Mouse (Murine) Polyclonal TACSTD2 Primary Antibody for FACS, ICC - ABIN4900492
Eisenwort, Jurkin, Yasmin, Bauer, Gesslbauer, Strobl: Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-?1-dependent human epidermal Langerhans cells. in The Journal of investigative dermatology 2011
Show all 5 references for ABIN4900492
Human Monoclonal TACSTD2 Primary Antibody for FACS, WB - ABIN4900015
Yamaguchi, Nishii, Nakamura, Aoki, Hirai, Uchida, Sakuma, Hamada: Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells. in Biochemical and biophysical research communications 2016
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Human Monoclonal TACSTD2 Primary Antibody for FACS - ABIN4897042
Hussain, Lawrence, Taylor, Lo, Frydenberg, Ellem, Furic, Risbridger: Estrogen receptor β activation impairs prostatic regeneration by inducing apoptosis in murine and human stem/progenitor enriched cell populations. in PLoS ONE 2012
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Human Polyclonal TACSTD2 Primary Antibody for ELISA, WB - ABIN316346
Shimada, Kano, Ishiyama, Okubo, Iijima, Morishita, Minami, Inadome, Shu, Sugita, Takeuchi, Noguchi: Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development. in Cancer science 2005
Mouse (Murine) Polyclonal TACSTD2 Primary Antibody for FACS - ABIN4897798
Stoyanova, Goldstein, Cai, Drake, Huang, Witte: Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. in Genes & development 2012
Human Polyclonal TACSTD2 Primary Antibody for EIA, WB - ABIN453439
Goldstein, Lawson, Cheng, Sun, Garraway, Witte: Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. in Proceedings of the National Academy of Sciences of the United States of America 2008
Trop-2 promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa (show ENPP1 Antibodies) cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa (show ENPP1 Antibodies).
studies have begun to identify the mechanisms underlying TROP2's functions, including regulated intramembrane proteolysis or specific interactions with integrin b1 and claudin proteins.
our findings help to establish a close functional link between Trop2 and MSCs, and to provide a tool for future investigation of Trop2 in other types of stem cells
data suggest that Trop2 regulates cell proliferation and motility and that it does so by regulating the ERK (show EPHB2 Antibodies) pathway and several critical components of the cell migration apparatus
Trop2 plays a cardioprotective role by promoting cardiac c-kit (show KIT Antibodies)+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.
Trop2 is a regulator of self-renewal, proliferation, and transformation
TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development.
these results uncover a role for Trop2 loss in tumorigenesis and the mesenchymal transdifferentiation observed in a subset of squamous cell carcinomas.
In human and mouse, Trop2 is highly expressed at both the transcript and protein levels on several essential normal tissues.
Study also provides the first indication of a molecular signaling pathway activated by Trop2 which has important implications for cancer cell growth and survival.
We identified a homozygous TACSTD2 missense mutation, c.551A>G, p.(Tyr184Cys), in the affected family members. Both parents were heterozygous for the mutation, and unaffected siblings were either heterozygous or homozygous wild-type for this allele.
Our results expand the mutational spectrum of TACSTD2 in patients with gelatinous drop-like corneal dystrophy (GDLD).
Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection.
Trop-2 is a novel target for ADC (show ADC Antibodies) therapy because of its high expression by many solid cancers.
TROP2 is epigenetically down-regulated and operates as a negative regulator of cell proliferation and migration in liver fluke-associated cholangiocarcinoma.
TROP-2 is specifically expressed in papillary thyroid carcinoma.
overexpression of TROP2 appears to be an independent predictor for poor clinical outcome in nasopharyngeal carcinoma
Lower GA733-2 (show EPCAM Antibodies) expression in cancer tissues appeared to correlate with lymph node metastases (P < 0.05). GA733-1 gene expression was significantly higher in cancerous samples
TROP-2 can be used as well as HBME-1 in thyroid cytology to detect PTC (show F9 Antibodies).
Altogether, our data suggest that TROP2 plays an important role in promoting ADC (show ADC Antibodies) and may represent a novel prognostic biomarker and therapeutic target for the disease.
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
tropomyosin beta chain
, 40kD glycoprotein, identified by monoclonal antibody GA733
, cell surface glycoprotein TROP2
, cell surface glycoprotein Trop-2
, epithelial glycoprotein-1
, gastrointestinal tumor-associated antigen GA7331
, membrane component chromosome 1 surface marker 1
, membrane component, chromosome 1, surface marker 1
, pancreatic carcinoma marker protein GA733-1
, pancreatic carcinoma marker protein GA7331
, lymphocyte antigen 97
, tunor-associated calcium signal transducer 2
, parturition-related protein 1