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This intronless gene encodes a carcinoma-associated antigen. Additionally we are shipping TACSTD2 Antibodies (176) and TACSTD2 Kits (3) and many more products for this protein.
Showing 10 out of 19 products:
Stress fibre formation and up-regulation of alpha-smooth muscle actin (show ACTG2 Proteins) (alphaSMA (show ACTA2 Proteins)) induced by TGFbeta2 could be reversed by Tpm1 (show TPM1 Proteins)/2 knock-down by siRNA.
Trop2 marks fetal glandular epithelial cells of the stomach, growing as spheroids when cultured ex vivo. In adults, upon injury, Trop2 expression is reactivated in regenerative cells together with part of a fetal-like genetic program.
Trop-2 promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa (show ENPP1 Proteins) cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa (show ENPP1 Proteins).
studies have begun to identify the mechanisms underlying TROP2's functions, including regulated intramembrane proteolysis or specific interactions with integrin b1 and claudin proteins.
our findings help to establish a close functional link between Trop2 and MSCs, and to provide a tool for future investigation of Trop2 in other types of stem cells
data suggest that Trop2 regulates cell proliferation and motility and that it does so by regulating the ERK (show EPHB2 Proteins) pathway and several critical components of the cell migration apparatus
Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.
Trop2 is a regulator of self-renewal, proliferation, and transformation
TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development.
these results uncover a role for Trop2 loss in tumorigenesis and the mesenchymal transdifferentiation observed in a subset of squamous cell carcinomas.
Our findings indicate that the expression of Trop-2 is a stringent predictor of tumor response to AKT (show AKT1 Proteins) inhibitors. They also support the identification of target-activatory pathways, as efficient predictors of response in precision cancer therapy.
Findings suggest that high TROP2 expression identifies distinct cell sub-populations in androgen-sensitive and androgen-independent prostate tumors and that it may be a predictive biomarker for prostate cancer treatment response in androgen-sensitive tumors.
TROP2 may play a crucial role in COPD (show ARCN1 Proteins) by affecting basal cells function and thus airway remodeling through increased basal cells hyperplasia
TROP2 was overexpressed specifically in the majority of epithelial ovarian cancer and may be a novel prognostic biomarker
we compared the diagnostic value of TROP-2 expression in distinguishing between benign and malignant thyroid lesions to those of HBME-1, CK19 (show KRT19 Proteins) and galectin-3 (show LGALS3 Proteins)
TROP-2 membranous staining is a very sensitive and specific marker for the classic and tall cell variants of papillary thyroid carcinoma, and for papillary microcarcinomas , with high overall specificity for papillary thyroid carcinoma
The results suggested that trop2 facilitated neovascularization of non-small-cell lung cancer via activating ERK1/2 signaling pathway.
We identified a homozygous TACSTD2 missense mutation, c.551A>G, p.(Tyr184Cys), in the affected family members. Both parents were heterozygous for the mutation, and unaffected siblings were either heterozygous or homozygous wild-type for this allele.
Our results expand the mutational spectrum of TACSTD2 in patients with gelatinous drop-like corneal dystrophy (GDLD).
Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection.
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
tropomyosin beta chain
, 40kD glycoprotein, identified by monoclonal antibody GA733
, cell surface glycoprotein TROP2
, cell surface glycoprotein Trop-2
, epithelial glycoprotein-1
, gastrointestinal tumor-associated antigen GA7331
, membrane component chromosome 1 surface marker 1
, membrane component, chromosome 1, surface marker 1
, pancreatic carcinoma marker protein GA733-1
, pancreatic carcinoma marker protein GA7331
, lymphocyte antigen 97
, tunor-associated calcium signal transducer 2
, parturition-related protein 1