Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. Additionally we are shipping TWIST2 Antibodies (45) and many more products for this protein.
Showing 5 out of 6 products:
A homozygous missense mutation in the TWIST2 gene was described in 3 siblings affected by Setleis syndrome. An alteration of bHLH domain, and loss of transcription factor's function was predicted due to protein substitution.
TWIST2 regulates epithelial-mesenchymal transition by depriving the epithelial cell phenotype of E-cadherin (show CDH1 Proteins) and endowing the mesenchymal cell phenotype with Vimentin (show VIM Proteins), which may be involved in the progression and prognosis of ovarian cancer.
MACC1 (show MACC1 Proteins) promotes vasculogenic mimicry in gastric cancer by regulating the HGF/c-Met-TWIST1 (show TWIST1 Proteins)/2 signaling pathway.
In patients with no duplication/triplication of the 1p36.22p36.21 region and no mutations in TWIST2, there are mutation(s) in one of the 30 genes in this region or mutations in other as yet unidentified genes at different locations
Data suggest that TWIST1 (show TWIST1 Proteins) and to a lesser degree TWIST2 expressed within the tumor stroma could contribute to the epithelial-mesenchymal transition (EMT (show ITK Proteins))-like tumor budding phenotype in colorectal cancers.
A substituted lysine at TWIST2 residue 75 results in Ablepharon Macrostomia Syndrome, whereas a glutamine or alanine yields Barber-Say Syndrome.
After chronic NOD2 stimulation, Twist1 (show TWIST1 Proteins) and Twist2 coordinate the regulation of both transcriptional activators and repressors, thereby mediating optimal cytokine down-regulation.
Results show that Twist2 expression was gradually increased during the progression from normal cervical squamous epithelium to cervical intraepithelial neoplasia (CIN (show PDXP Proteins)) and cervical squamous cell carcinoma.
Data have identified a novel TWIST2-p21 (show CDKN1A Proteins) axis that regulates the cell cycle of both normal and leukemic hematopoietic cells, which implicates TWIST2 as a novel tumor suppressor in human acute myeloid leukemia (show BCL11A Proteins).
TWIST1 (show TWIST1 Proteins) and TWIST2 are expressed in skeletal muscle and remained unaltered in metabolic diseases.
The Twist2-Cre, Osterix (show SP7 Proteins)-Cre and osteocalcin (show BGLAP Proteins)-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.
Twist-2 was involved in endotoxin tolerance through inhibiting NF-kappaB (show NFKB1 Proteins) transactivation and cytokines transcriptional activities.
Twist2 functions as a tumor suppressor in osteosarcoma cells.
we identify Twist2 as a key regulator of survival, invasion and anchorage-independent growth in the aneuploid cells
Wnt (show WNT2 Proteins) signaling/beta-catenin (show CTNNB1 Proteins) is absolutely required and sufficient for Dermo1 expression and dermal cell identity in the cranium.
Twist2 is required for normal corneal keratocyte proliferation and eyelid morphogenesis in the mouse.
TWIST2 recessive mutations cause an focal facial dermal dysplasias and dominant TWIST1 (show TWIST1 Proteins) mutations cause Saethre-Chotzen craniocynostosis suggests that they function independently in skin and bone development.
Using the N-terminal domain of ADD1/SREBP1c (show SREBF1 Proteins) as bait, we identified Twist2 (also known as Dermo-1), a basic helix-loop-helix (bHLH) protein, as a novel ADD1/SREBP1c (show SREBF1 Proteins) interacting protein
Twist1 (show TWIST1 Proteins) and Twist2 factors are cross-regulated and inhibit bone specific gene expression and other helix-loop-helix proteins
Twist-2 activates the transcription factor c-Maf (show MAF Proteins), leading to IL-10 (show IL10 Proteins) expression. It is essential for endotoxin tolerance.
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype. Two transcript variants encoding the same protein have been found for this gene.
twist homolog 2 (Drosophila)
, twist-related protein 2
, class A basic helix-loop-helix protein 39
, dermis-expressed protein 1
, twist homolog 2
, twist-related bHLH protein Dermo1
, dermis expressed 1
, dermo-1 protein