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Twist Homolog 2 (Drosophila) Proteins (TWIST2)

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. Additionally we are shipping TWIST2 Antibodies (74) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TWIST2 117581 Q8WVJ9
TWIST2 13345 Q9D030
TWIST2 59327 P97831
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Top TWIST2 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

TWIST2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Twist Homolog 2 (Drosophila) (TWIST2) Interaction Partners

Human Twist Homolog 2 (Drosophila) (TWIST2) interaction partners

  1. Findings indicated that HIF-2alpha (show EPAS1 Proteins) promotes epithelial-mesenchymal transition in pancreatic cancer by regulating Twist2 binding to the promoter of E-cadherin (show CDH1 Proteins).

  2. A homozygous missense mutation in the TWIST2 gene was described in 3 siblings affected by Setleis syndrome. An alteration of bHLH domain, and loss of transcription factor's function was predicted due to protein substitution.

  3. TWIST2 regulates epithelial-mesenchymal transition by depriving the epithelial cell phenotype of E-cadherin (show CDH1 Proteins) and endowing the mesenchymal cell phenotype with Vimentin (show VIM Proteins), which may be involved in the progression and prognosis of ovarian cancer.

  4. MACC1 (show MACC1 Proteins) promotes vasculogenic mimicry in gastric cancer by regulating the HGF/c-Met-TWIST1 (show TWIST1 Proteins)/2 signaling pathway.

  5. In patients with no duplication/triplication of the 1p36.22p36.21 region and no mutations in TWIST2, there are mutation(s) in one of the 30 genes in this region or mutations in other as yet unidentified genes at different locations

  6. Data suggest that TWIST1 (show TWIST1 Proteins) and to a lesser degree TWIST2 expressed within the tumor stroma could contribute to the epithelial-mesenchymal transition (EMT (show ITK Proteins))-like tumor budding phenotype in colorectal cancers.

  7. A substituted lysine at TWIST2 residue 75 results in Ablepharon Macrostomia Syndrome, whereas a glutamine or alanine yields Barber-Say Syndrome.

  8. After chronic NOD2 stimulation, Twist1 (show TWIST1 Proteins) and Twist2 coordinate the regulation of both transcriptional activators and repressors, thereby mediating optimal cytokine down-regulation.

  9. Results show that Twist2 expression was gradually increased during the progression from normal cervical squamous epithelium to cervical intraepithelial neoplasia (CIN (show PDXP Proteins)) and cervical squamous cell carcinoma.

  10. Data have identified a novel TWIST2-p21 (show CDKN1A Proteins) axis that regulates the cell cycle of both normal and leukemic hematopoietic cells, which implicates TWIST2 as a novel tumor suppressor in human acute myeloid leukemia (show BCL11A Proteins).

Mouse (Murine) Twist Homolog 2 (Drosophila) (TWIST2) interaction partners

  1. The Twist2-Cre, Osterix (show SP7 Proteins)-Cre and osteocalcin (show BGLAP Proteins)-Cre lines to generate conditional beta1 integrin deletions, were used to investigate the role of beta1 integrins on skeletal phenotype.

  2. Twist-2 was involved in endotoxin tolerance through inhibiting NF-kappaB (show NFKB1 Proteins) transactivation and cytokines transcriptional activities.

  3. Twist2 functions as a tumor suppressor in osteosarcoma cells.

  4. we identify Twist2 as a key regulator of survival, invasion and anchorage-independent growth in the aneuploid cells

  5. Wnt (show WNT2 Proteins) signaling/beta-catenin (show CTNNB1 Proteins) is absolutely required and sufficient for Dermo1 expression and dermal cell identity in the cranium.

  6. Twist2 is required for normal corneal keratocyte proliferation and eyelid morphogenesis in the mouse.

  7. TWIST2 recessive mutations cause an focal facial dermal dysplasias and dominant TWIST1 (show TWIST1 Proteins) mutations cause Saethre-Chotzen craniocynostosis suggests that they function independently in skin and bone development.

  8. Using the N-terminal domain of ADD1/SREBP1c (show SREBF1 Proteins) as bait, we identified Twist2 (also known as Dermo-1), a basic helix-loop-helix (bHLH) protein, as a novel ADD1/SREBP1c (show SREBF1 Proteins) interacting protein

  9. Twist1 (show TWIST1 Proteins) and Twist2 factors are cross-regulated and inhibit bone specific gene expression and other helix-loop-helix proteins

  10. Twist-2 activates the transcription factor c-Maf (show MAF Proteins), leading to IL-10 (show IL10 Proteins) expression. It is essential for endotoxin tolerance.

TWIST2 Protein Profile

Protein Summary

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with TWIST2

  • twist homolog 2 (Drosophila) (TWIST2)
  • twist basic helix-loop-helix transcription factor 2 (TWIST2)
  • twist basic helix-loop-helix transcription factor 2 (Twist2)
  • bHLHa39 protein
  • CDERMO-1 protein
  • Dermo1 protein
  • FFDD3 protein
  • SETLSS protein
  • TWIST2 protein

Protein level used designations for TWIST2

twist homolog 2 (Drosophila) , twist-related protein 2 , class A basic helix-loop-helix protein 39 , dermis-expressed protein 1 , twist homolog 2 , twist-related bHLH protein Dermo1 , dermis expressed 1 , dermo-1 , dermo-1 protein , dermo

486185 Canis lupus familiaris
697078 Macaca mulatta
117581 Homo sapiens
13345 Mus musculus
59327 Rattus norvegicus
395405 Gallus gallus
540060 Bos taurus
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