Twisted Gastrulation Homolog 1 (Drosophila) Proteins (TWSG1)

May be involved in dorsoventral axis formation. Additionally we are shipping TWSG1 Antibodies (42) and TWSG1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TWSG1 65960 Q9EP52
TWSG1 57045 Q9GZX9
Rat TWSG1 TWSG1 363294  
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Top TWSG1 Proteins at

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 50 μg Log in to see 12 to 15 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 6 to 8 Days
HOST_HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days

TWSG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , , , ,

Top referenced TWSG1 Proteins

  1. Human TWSG1 Protein expressed in Wheat germ - ABIN1324209 : Tanno, Bhanu, Oneal, Goh, Staker, Lee, Moroney, Reed, Luban, Wang, Eling, Childs, Ganz, Leitman, Fucharoen, Miller: High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. in Nature medicine 2007 (PubMed)

More Proteins for Twisted Gastrulation Homolog 1 (Drosophila) (TWSG1) Interaction Partners

Zebrafish Twisted Gastrulation Homolog 1 (Drosophila) (TWSG1) interaction partners

  1. Twisted (show POMT2 Proteins) gastrulation enhances BMP signaling through chordin (show CHRD Proteins) dependent and independent mechanisms

Mouse (Murine) Twisted Gastrulation Homolog 1 (Drosophila) (TWSG1) interaction partners

  1. Our results show that BMP binding is required for TWSG1-mediated inhibition of osteoclast formation and function, and validate the critical functional regions within the TWSG1 protein for these interactions

  2. The goal of this study was to examine whether mice carrying a mutation in a gene encoding Twsg1, which is associated with a low penetrance of holoprosencephaly, are sensitized to retinoic acid teratogenesis.

  3. BMP-binding protein twisted (show POMT2 Proteins) gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization.

  4. Data show that Bmp4 (show BMP4 Proteins), Bmp7 (show BMP7 Proteins), Gremlin (show GREM1 Proteins) and Twisted (show POMT2 Proteins) gastrulation (Twsg1) are all expressed in the thymus and expression was clearly different for each gene investigated.

  5. suggesting that Twsg1 expression in B cells serves to interpret BMP signals on a per-cell basis

  6. These results demonstrate that phenotypic variability in Twsg1-/- mice is associated with differential expression of certain developmentally regulated genes, and that craniofacial defects can be partially rescued by reduced p53 (show TP53 Proteins) levels.

  7. TWSG1 overexpression inhibits RANKL (show TNFSF11 Proteins)-induced osteoclast differentiation

  8. TWSG1 appears to be the main regulator of BMP present in CP.

  9. Cv2 (show BMPER Proteins) enhances pro-BMP activity of Tsg.

  10. The developmentally regulated expression of Twisted (show POMT2 Proteins) gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development.

Human Twisted Gastrulation Homolog 1 (Drosophila) (TWSG1) interaction partners

  1. Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling.

  2. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.

  3. mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies

  4. Tsg functions as an agonist synergizing with TGF-beta (show TGFB1 Proteins) to inhibit T-cell activation.

  5. interferes with BMP-mediated hepcidin (show HAMP Proteins) expression and may act with GDF15 (show GDF15 Proteins) to dysregulate iron homeostasis in thalassemia syndromes.

Cow (Bovine) Twisted Gastrulation Homolog 1 (Drosophila) (TWSG1) interaction partners

  1. TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation

TWSG1 Protein Profile

Protein Summary

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).

Gene names and symbols associated with TWSG1

  • twisted gastrulation homolog 1a (Drosophila) (twsg1a)
  • twisted gastrulation homolog 1 (Drosophila) (TWSG1)
  • twisted gastrulation homolog 1 (Drosophila) (Twsg1)
  • 1810013J15Rik protein
  • 9030422N06Rik protein
  • AW552143 protein
  • D17Ertd403e protein
  • DKFZp469J051 protein
  • fi23f01 protein
  • Tsg protein
  • tsga protein
  • Twg protein
  • TWSG1 protein
  • wu:fi23f01 protein

Protein level used designations for TWSG1

twisted gastrulation 1 , twisted gastrulation a , twisted gastrulation protein homolog 1-A , twisted gastrulation homolog 1 (Drosophila) , twisted gastrulation homolog 1 , Twisted gastrulation protein homolog 1 , twisted gastrulation protein homolog 1

84037 Danio rerio
455294 Pan troglodytes
705804 Macaca mulatta
100172557 Pongo abelii
65960 Mus musculus
57045 Homo sapiens
374024 Gallus gallus
490546 Canis lupus familiaris
537290 Bos taurus
363294 Rattus norvegicus
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