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TYRP1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Additionally we are shipping Tyrosinase-Related Protein 1 Proteins (12) and Tyrosinase-Related Protein 1 Kits (1) and many more products for this protein.
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Chicken Polyclonal Tyrosinase-Related Protein 1 Primary Antibody for IHC, WB - ABIN2781815
Horibe, Satoh, Shiota, Kumagai, Horike, Takemori, Uesato, Sugie, Obata, Kawahara, Nagaoka: Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells. in Journal of natural medicines 2013
Chicken Polyclonal Tyrosinase-Related Protein 1 Primary Antibody for WB - ABIN2781813
Forshew, Khaliq, Tee, Smith, Johnson, Mehdi, Maher: Identification of novel TYR and TYRP1 mutations in oculocutaneous albinism. in Clinical genetics 2005
a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, causes melanophore death leading to a semi-dominant phenotype
The Fugu tyrp1 promoter can direct transgene expression in a cell-type-specific manner in zebrafish. Our findings provide evidence supporting differential regulations of melanin-synthesizing genes in RPE (show RPE Antibodies) cells and the NCDM in zebrafish.
A mutation in exon 2 of the TYRP1 gene leads to a premature stop codon at position 190 of the deduced amino acid sequence. Genotyping 203 rabbits of 32 different breeds identified this mutation only in brown Havana rabbits.
Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.
Mutation in TYRP1 is associated with oculocutaneous albinism.
Polymorphisms in 3'UTR (show UTS2R Antibodies) of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR (show MLXIP Antibodies)-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR (show MLXIP Antibodies)-155 activity
These data suggest that UVB-stimulated Ucn1 (show UCN Antibodies) contributes to TRP1 (show PRSS1 Antibodies) production via the transcription of both Nurr-1 (show NR4A2 Antibodies) and Nur77 (show NR4A1 Antibodies). Ucn1 (show UCN Antibodies), produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
These data indicate that galectin-3 (show LGALS3 Antibodies) is a regulatory component in melanin synthesis affecting the expression of Tyrp-1.
p53 (show TP53 Antibodies) regulation by TRP2 (show DCT Antibodies) is not pervasive in melanoma.
Due to mutation in Tyrp1 protein, it became more rigid and might disturb the structural conformation and catalytic function of the structure and might also play a significant role in inducing oculocutaneous albinism type III.
in human melanoma HMV-II cells both CRF (show CRH Antibodies) and Ucn1 (show UCN Antibodies) regulate TRP1 (show PRSS1 Antibodies) gene expression via Nurr-1 (show NR4A2 Antibodies)/Nur77 (show NR4A1 Antibodies) production, independent of pro-opiomelanocortin (show POMC Antibodies) or alpha-melanocyte-stimulating hormone (show POMC Antibodies) stimulation.
High TYRP1/S100B (show S100B Antibodies) mRNA expression in lymph node metastases from melanoma patients is associated with unfavourable clinical outcome.
We report four Pakistani albinism mutations, including three SLC45A2 (show SLC45A2 Antibodies) alleles and one 22-nucleotide deletion in TYRP1.
A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.
Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.
Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb.
the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 (show TRPC1 Antibodies) protein expression by post-transcriptional control in B16F10 cells
Studied upregulation by Kaliziri extract of tyrosinase (show TYR Antibodies), TRP-1 (show TRPC1 Antibodies), TRP-2 (show DCT Antibodies) and MITF (show MITF Antibodies) expression in murine B16 melanoma cells.
The SNARE (show VTI1B Antibodies) machinery composed of VAMP7 (show VAMP7 Antibodies) on Tyrp1-containing vesicles and syntaxin-3 (show STX3 Antibodies) and SNAP23 (show SNAP23 Antibodies) on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.
Addition of a TRP-1 (show TRPC1 Antibodies)-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions.
analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage
GILT (show IFI30 Antibodies)-deficient mice have an increase in TRP1 (show TRPC1 Antibodies)-specific regulatory T (Treg) cells compared with TRP1 (show TRPC1 Antibodies)-deficient mice, and depletion of Treg cells partially restores the ability of GILT (show IFI30 Antibodies)-deficient TRP1 (show TRPC1 Antibodies)-specific CD4 (show CD4 Antibodies)(+) T cells to induce vitiligo (show MITF Antibodies).
The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions.
DNA vaccination with a melanoma-shared antigen Trp1 (show TRPC1 Antibodies), combined with systemic TGF-beta (show TGFB1 Antibodies) blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma.
both the Rab32 (show RAB32 Antibodies)/38 binding activity and VAMP7 (show VAMP7 Antibodies) binding activity of Varp (show ANKRD27 Antibodies) are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 (show RAB21 Antibodies) by the VPS9 domain is not necessary for Tyrp1 trafficking
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
5,6-dihydroxyindole-2-carboxylic acid oxidase
, tyrosinase-related protein 1
, 5,6-dihydroxyindole-2-carboxylic acid oxidase-like
, short transient receptor potential channel 1
, transient receptor protein 1
, DHICA oxidase
, catalase B
, glycoprotein 75
, melanoma antigen gp75
, tyrosinase-related protein-1
, brown locus protein
, iris stromal atrophy
, tyrosine phosphatase 1, same as B (Brown)