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anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Antibodies

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (4) and PTPN22 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPN22 19260 P29352
PTPN22 26191 Q9Y2R2
PTPN22 295338  
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Top anti-PTPN22 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using PTPN22  Antibody (C-term). This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of PTPN22 expression in transfected 293T cell line by PTPN22 MaxPab polyclonal antibody.Lane1:PTPN22 transfected lysate(82.72 KDa).Lane2:Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB PTPN22 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Chicken Un-conjugated WB 0.05 mg Log in to see 2 to 3 Days
$446.88
Details
Human Mouse Un-conjugated WB Western blot analysis of PTPN22 over-expressed 293 cell line, cotransfected with PTPN22 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of PTPN22 expression in transfected 293T cell line by PTPN22 monoclonal antibody (M01), clone 4F6. Lane 1: PTPN22 transfected lysate(85.1 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$405.17
Details

PTPN22 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


Human , , ,
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Rat (Rattus) ,


Top referenced anti-PTPN22 Antibodies

  1. Human Polyclonal PTPN22 Primary Antibody for EIA, WB - ABIN954376 : Bianco, Verreschi, Oliveira, Guedes, Galera, Galera, Barbosa, Lipay: PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome. in Scandinavian journal of immunology 2010 (PubMed)
    Show all 3 references for ABIN954376

  2. Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622 : Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012 (PubMed)

More Antibodies against PTPN22 Interaction Partners

Mouse (Murine) Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. our data suggest a critical role for GITR (show TNFRSF18 Antibodies) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  2. Tec (show NR4A3 Antibodies) enhances c-Maf (show MAF Antibodies)-dependent IL-4 (show IL4 Antibodies) promoter activity. This effect of Tec (show NR4A3 Antibodies) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF Antibodies) thereby attenuating its transcriptional activity.

  3. lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3 (show FOXP3 Antibodies)(+) Treg and Tr1 (show TXNRD1 Antibodies) cells

  4. Ptpn22 and Cd2 (show CCND2 Antibodies) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes

  5. T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.

  6. PTPN22 is an inhibitor of PAD-4 (show PADI4 Antibodies) and protein citrullination.

  7. Autoimmunity-associated protein tyrosine phosphatase (show ACP1 Antibodies) PEP (show PREP Antibodies) negatively regulates IFN-alpha (show IFNA Antibodies) receptor signaling.

  8. lack of Ptpn22 exacerbates virally-induced type 1 diabetes in lymphocytic choriomeningitis virus mice, while maintaining higher number of Treg cells in the antiviral response in the blood and spleen but not in the pancreatic lymph nodes

  9. Data suggest that a gain-of-function of human PTPN22 transgene encoding the tyrosine phosphatase LYP is unlikely to increase risk of autoimmunity through alterations of thymic selection.

  10. PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens.

Human Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. sex-specific pattern of association is broadly applicable to different populations, and provides further impetus to undertake mechanistic studies to understand the impact of sex on PTPN22 in JIA.

  2. PTPN22 gene variants were associated with type 1 diabetes susceptibility and autoimmune polyglandular syndrome type III.

  3. Our results do not support association between PTPN22/CSK (show CSK Antibodies) and Henoch-Schonlein purpura

  4. The findings suggest that PTPN22 polymorphisms may predispose the chronicity or the development of cirrhosis and hepatocellular carcinoma in HBV infection.

  5. The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females

  6. rs56048322 was significantly associated with type 1 diabetes. rs56048322 affects splicing, resulting in a novel isoform of LYP which competes with the wild-type for binding to CSK (show CSK Antibodies) and results in hyporesponsiveness of CD4 (show CD4 Antibodies)+ T cells to antigen stimulation.

  7. role of PTPN22 in type 1 diabetes and Crohn's disease (review

  8. a significant association between PTPN22 R620W polymorphism and MG risk: PTPN22 R620W polymorphism showed increased early-onset myasthenia gravis (EOMG) risk (OR=2.38; 95% CI, 1.52-3.71; I(2)=0%)(Meta-Analysis)

  9. ADA6, PTPN22 and ACP1 (show ACP1 Antibodies) are involved in immune reactions: since endometriosis has an autoimmune component.

  10. suggests that the rs2476601 polymorphism of PTPN22 gene is mono-morphic in Iranian population, containing only C allele

PTPN22 Antigen Profile

Protein Summary

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PTPN22

  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) antibody
  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) antibody
  • 70zpep antibody
  • LYP antibody
  • LYP1 antibody
  • LYP2 antibody
  • PEP antibody
  • PTPN8 antibody

Protein level used designations for PTPN22

PEST domain-enriched tyrosine phosphatase , hematopoietic cell protein-tyrosine phosphatase 70Z-PEP , protein tyrosine phosphatase, non-receptor type 8 , tyrosine-protein phosphatase non-receptor type 22 , PEST-domain phosphatase , lymphoid phosphatase , lymphoid-specific protein tyrosine phosphatase

GENE ID SPECIES
19260 Mus musculus
26191 Homo sapiens
295338 Rattus norvegicus
Selected quality suppliers for anti-PTPN22 (PTPN22) Antibodies
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