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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (6) and PTPN22 Kits (1) and many more products for this protein.
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Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622
Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012
Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp (show TYRP1 Antibodies) polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.
PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon (show IFNA Antibodies) signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.
PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (show ITGAL Antibodies) ligand intercellular adhesion molecule-1 (ICAM-1 (show ICAM1 Antibodies)).
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals
PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 Antibodies) phosphorylation, but reduced levels of mature IL-1beta (show IL1B Antibodies).
We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.
this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis
report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.
PTPN22 single nucleotide polymorphism is associated with type 1 diabetes in Iran
Relationship with insulin (show INS Antibodies)-dependent diabetes mellitus was found only in polymorphism R620W
The associations observed between PTPN22 (C1858T) and the risk of endometriosis suggest this polymorphism might be a useful susceptibility marker for this disease.
the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 c.1858C>T (rs2476601), TLR4 (show TLR4 Antibodies) c.896A>G (rs4986790) and TLR4 (show TLR4 Antibodies) c.1196C>T (rs4986791), IL7R (show IL7R Antibodies) c.197T>C (rs1494555) and IL7R (show IL7R Antibodies) c.412G>A (rs1494558).
PTPN22 variants are associated with ANCA-associated vasculitis risk.
C1858T polymorphism of protein tyrosine phosphatase (show ACP1 Antibodies) non-receptor type 22 characterizes a subset of type 1 diabetic patients with higher levels of C-peptide at diagnosis and lower insulin (show INS Antibodies) requirement at 6 months from diagnosis.
The presence of PTPN22 1858C-->T polymorphism with HLA shared epitope and autoantibodies increases risk of rheumaotid arthritis development and erosive disease.
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase