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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (6) and PTPN22 Kits (1) and many more products for this protein.
Showing 10 out of 64 products:
Human Polyclonal PTPN22 Primary Antibody for EIA, WB - ABIN954376
Bianco, Verreschi, Oliveira, Guedes, Galera, Galera, Barbosa, Lipay: PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome. in Scandinavian journal of immunology 2010
Show all 3 references for ABIN954376
Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622
Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012
report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.
our data suggest a critical role for GITR (show TNFRSF18 Antibodies) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior
Tec (show NR4A3 Antibodies) enhances c-Maf (show MAF Antibodies)-dependent IL-4 (show IL4 Antibodies) promoter activity. This effect of Tec (show NR4A3 Antibodies) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF Antibodies) thereby attenuating its transcriptional activity.
lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3 (show FOXP3 Antibodies)(+) Treg and Tr1 (show TXNRD1 Antibodies) cells
Ptpn22 and Cd2 (show CCND2 Antibodies) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes
T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.
PTPN22 is an inhibitor of PAD-4 (show PADI4 Antibodies) and protein citrullination.
Autoimmunity-associated protein tyrosine phosphatase (show ACP1 Antibodies) PEP (show PREP Antibodies) negatively regulates IFN-alpha (show IFNA Antibodies) receptor signaling.
lack of Ptpn22 exacerbates virally-induced type 1 diabetes in lymphocytic choriomeningitis virus mice, while maintaining higher number of Treg cells in the antiviral response in the blood and spleen but not in the pancreatic lymph nodes
Data suggest that a gain-of-function of human PTPN22 transgene encoding the tyrosine phosphatase LYP is unlikely to increase risk of autoimmunity through alterations of thymic selection.
This study reveals a significant association between SNPs in PTPN22, CTLA-4 gene and AR with asthma in Chinese Han children, which might be susceptibility factors for Allergic rhinitis and asthma.
The association of PTPN22 variant, R620W (LypW), with defects in trivalent influenza vaccine-induced CD4 (show CD4 Antibodies)(+) T-cell expansion and antibody affinity maturation suggests that LypW may predispose individuals to have a diminished capacity to generate protective immunity against influenza virus.
PTPN22 + 1858 T allele predisposes European individuals to vitiligo (show MITF Antibodies).
These data support that PTPN22 1858C/T, PTPRJ (show PTPRJ Antibodies) 2965C/G and 1176 A/C polymorphisms and ACP1 A (show ACP1 Antibodies), B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults.
this study reveals that the +1858T allele in the PTPN22 gene is associated with Rheumatoid Arthritis and Celiac Disease in a population from the south-west of Iran.
PTPN22 Gene Polymorphism rs1310182 has a role in juvenile idiopathic arthritis
The functional PTPN22 C1858T polymorphism was associated with an increased risk for Rheumatoid arthritis in the Mexican population.
this study shows that PTPN22 contributes to rheumatoid arthritis susceptibility in Egyptians
this study shows that PTPN22 gene polymorphism is associated wit the risk of allergic rhinitis in China
this study shows that PTPN22 polymorphism is associated with susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase