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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (6) and PTPN22 Kits (1) and many more products for this protein.
Showing 10 out of 64 products:
Human Polyclonal PTPN22 Primary Antibody for EIA, WB - ABIN954376
Bianco, Verreschi, Oliveira, Guedes, Galera, Galera, Barbosa, Lipay: PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome. in Scandinavian journal of immunology 2010
Show all 3 references for 954376
Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622
Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012
We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.
this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis
report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.
our data suggest a critical role for GITR (show TNFRSF18 Antibodies) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior
Tec (show NR4A3 Antibodies) enhances c-Maf (show MAF Antibodies)-dependent IL-4 (show IL4 Antibodies) promoter activity. This effect of Tec (show NR4A3 Antibodies) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF Antibodies) thereby attenuating its transcriptional activity.
lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3 (show FOXP3 Antibodies)(+) Treg and Tr1 (show TXNRD1 Antibodies) cells
Ptpn22 and Cd2 (show CCND2 Antibodies) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes
T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.
PTPN22 is an inhibitor of PAD-4 (show PADI4 Antibodies) and protein citrullination.
Autoimmunity-associated protein tyrosine phosphatase (show ACP1 Antibodies) PEP (show PREP Antibodies) negatively regulates IFN-alpha (show IFNA Antibodies) receptor signaling.
the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 c.1858C>T (rs2476601), TLR4 (show TLR4 Antibodies) c.896A>G (rs4986790) and TLR4 (show TLR4 Antibodies) c.1196C>T (rs4986791), IL7R (show IL7R Antibodies) c.197T>C (rs1494555) and IL7R (show IL7R Antibodies) c.412G>A (rs1494558).
PTPN22 variants are associated with ANCA-associated vasculitis risk.
C1858T polymorphism of protein tyrosine phosphatase (show ACP1 Antibodies) non-receptor type 22 characterizes a subset of type 1 diabetic patients with higher levels of C-peptide at diagnosis and lower insulin (show INS Antibodies) requirement at 6 months from diagnosis.
The presence of PTPN22 1858C-->T polymorphism with HLA shared epitope and autoantibodies increases risk of rheumaotid arthritis development and erosive disease.
for the first time addressed how presence of SNP rs2476601 within the PTPN22 gene affects clinical characteristics in IBD-patients. Several factors that correlate with more severe disease were found to be less common in CD patients carrying the A-allele, pointing towards a protective role for this variant in affected CD patients
A significant association was found between the rs2476601 polymorphism of the PTPN22 gene and cystic fibrosis (show S100A8 Antibodies) in Mexican patients
The PTPN22 R620W minor allele frequency was increased in IIM patients (50 of 398, 12.6%) compared with controls.
This study reveals a significant association between SNPs in PTPN22, CTLA-4 gene and AR with asthma in Chinese Han children, which might be susceptibility factors for Allergic rhinitis and asthma.
The association of PTPN22 variant, R620W (LypW), with defects in trivalent influenza vaccine-induced CD4 (show CD4 Antibodies)(+) T-cell expansion and antibody affinity maturation suggests that LypW may predispose individuals to have a diminished capacity to generate protective immunity against influenza virus.
PTPN22 + 1858 T allele predisposes European individuals to vitiligo (show MITF Antibodies).
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase