anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Antibodies

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (6) and PTPN22 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPN22 19260 P29352
PTPN22 26191 Q9Y2R2
PTPN22 295338  
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Top anti-PTPN22 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using PTPN22  Antibody (C-term). This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated WB Host: Rabbit Target Name: PTPN22 Sample Type: Thyroid Tumor lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of PTPN22 expression in transfected 293T cell line by PTPN22 MaxPab polyclonal antibody.<br><br>Lane1:PTPN22 transfected lysate(82.72 KDa).<br>Lane2:Non-transfected lysate.<br> 50 μL Log in to see 11 to 12 Days
$430.00
Details
Human Goat Un-conjugated IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB PTPN22 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$323.13
Details
Human Chicken Un-conjugated WB 0.05 mg Log in to see 2 to 3 Days
$446.88
Details

PTPN22 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


Human , , ,
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Rat (Rattus) ,


Top referenced anti-PTPN22 Antibodies

  1. Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622 : Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012 (PubMed)

More Antibodies against PTPN22 Interaction Partners

Mouse (Murine) Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

  2. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals

  3. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 Antibodies) phosphorylation, but reduced levels of mature IL-1beta (show IL1B Antibodies).

  4. We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.

  5. this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis

  6. report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.

  7. our data suggest a critical role for GITR (show TNFRSF18 Antibodies) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  8. Tec (show NR4A3 Antibodies) enhances c-Maf (show MAF Antibodies)-dependent IL-4 (show IL4 Antibodies) promoter activity. This effect of Tec (show NR4A3 Antibodies) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF Antibodies) thereby attenuating its transcriptional activity.

  9. lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3 (show FOXP3 Antibodies)(+) Treg and Tr1 (show TXNRD1 Antibodies) cells

  10. Ptpn22 and Cd2 (show CCND2 Antibodies) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes

Human Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals

  2. The associations observed between PTPN22 (C1858T) and the risk of endometriosis suggest this polymorphism might be a useful susceptibility marker for this disease.

  3. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 Antibodies) phosphorylation, but reduced levels of mature IL-1beta (show IL1B Antibodies).

  4. the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 c.1858C>T (rs2476601), TLR4 (show TLR4 Antibodies) c.896A>G (rs4986790) and TLR4 (show TLR4 Antibodies) c.1196C>T (rs4986791), IL7R (show IL7R Antibodies) c.197T>C (rs1494555) and IL7R (show IL7R Antibodies) c.412G>A (rs1494558).

  5. PTPN22 variants are associated with ANCA-associated vasculitis risk.

  6. C1858T polymorphism of protein tyrosine phosphatase (show ACP1 Antibodies) non-receptor type 22 characterizes a subset of type 1 diabetic patients with higher levels of C-peptide at diagnosis and lower insulin (show INS Antibodies) requirement at 6 months from diagnosis.

  7. The presence of PTPN22 1858C-->T polymorphism with HLA shared epitope and autoantibodies increases risk of rheumaotid arthritis development and erosive disease.

  8. for the first time addressed how presence of SNP rs2476601 within the PTPN22 gene affects clinical characteristics in IBD-patients. Several factors that correlate with more severe disease were found to be less common in CD patients carrying the A-allele, pointing towards a protective role for this variant in affected CD patients

  9. A significant association was found between the rs2476601 polymorphism of the PTPN22 gene and cystic fibrosis (show S100A8 Antibodies) in Mexican patients

  10. The PTPN22 R620W minor allele frequency was increased in IIM patients (50 of 398, 12.6%) compared with controls.

PTPN22 Antigen Profile

Protein Summary

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PTPN22

  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) antibody
  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) antibody
  • 70zpep antibody
  • LYP antibody
  • LYP1 antibody
  • LYP2 antibody
  • PEP antibody
  • PTPN8 antibody

Protein level used designations for PTPN22

PEST domain-enriched tyrosine phosphatase , hematopoietic cell protein-tyrosine phosphatase 70Z-PEP , protein tyrosine phosphatase, non-receptor type 8 , tyrosine-protein phosphatase non-receptor type 22 , PEST-domain phosphatase , lymphoid phosphatase , lymphoid-specific protein tyrosine phosphatase

GENE ID SPECIES
19260 Mus musculus
26191 Homo sapiens
295338 Rattus norvegicus
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