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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Antibodies (65) and PTPN22 Proteins (6) and many more products for this protein.
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PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals
PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 ELISA Kits) phosphorylation, but reduced levels of mature IL-1beta (show IL1B ELISA Kits).
We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.
this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis
report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.
our data suggest a critical role for GITR (show TNFRSF18 ELISA Kits) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior
Tec (show NR4A3 ELISA Kits) enhances c-Maf (show MAF ELISA Kits)-dependent IL-4 (show IL4 ELISA Kits) promoter activity. This effect of Tec (show NR4A3 ELISA Kits) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF ELISA Kits) thereby attenuating its transcriptional activity.
lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells
Ptpn22 and Cd2 (show CCND2 ELISA Kits) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes
The associations observed between PTPN22 (C1858T) and the risk of endometriosis suggest this polymorphism might be a useful susceptibility marker for this disease.
the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 c.1858C>T (rs2476601), TLR4 (show TLR4 ELISA Kits) c.896A>G (rs4986790) and TLR4 (show TLR4 ELISA Kits) c.1196C>T (rs4986791), IL7R (show IL7R ELISA Kits) c.197T>C (rs1494555) and IL7R (show IL7R ELISA Kits) c.412G>A (rs1494558).
PTPN22 variants are associated with ANCA-associated vasculitis risk.
C1858T polymorphism of protein tyrosine phosphatase (show ACP1 ELISA Kits) non-receptor type 22 characterizes a subset of type 1 diabetic patients with higher levels of C-peptide at diagnosis and lower insulin (show INS ELISA Kits) requirement at 6 months from diagnosis.
The presence of PTPN22 1858C-->T polymorphism with HLA shared epitope and autoantibodies increases risk of rheumaotid arthritis development and erosive disease.
for the first time addressed how presence of SNP rs2476601 within the PTPN22 gene affects clinical characteristics in IBD-patients. Several factors that correlate with more severe disease were found to be less common in CD patients carrying the A-allele, pointing towards a protective role for this variant in affected CD patients
A significant association was found between the rs2476601 polymorphism of the PTPN22 gene and cystic fibrosis (show S100A8 ELISA Kits) in Mexican patients
The PTPN22 R620W minor allele frequency was increased in IIM patients (50 of 398, 12.6%) compared with controls.
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase