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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Antibodies (65) and PTPN22 Proteins (6) and many more products for this protein.
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our data suggest a critical role for GITR (show TNFRSF18 ELISA Kits) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior
Tec (show NR4A3 ELISA Kits) enhances c-Maf (show MAF ELISA Kits)-dependent IL-4 (show IL4 ELISA Kits) promoter activity. This effect of Tec (show NR4A3 ELISA Kits) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF ELISA Kits) thereby attenuating its transcriptional activity.
lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells
Ptpn22 and Cd2 (show CCND2 ELISA Kits) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes
T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.
PTPN22 is an inhibitor of PAD-4 (show PADI4 ELISA Kits) and protein citrullination.
Autoimmunity-associated protein tyrosine phosphatase (show ACP1 ELISA Kits) PEP (show PREP ELISA Kits) negatively regulates IFN-alpha (show IFNA ELISA Kits) receptor signaling.
lack of Ptpn22 exacerbates virally-induced type 1 diabetes in lymphocytic choriomeningitis virus mice, while maintaining higher number of Treg cells in the antiviral response in the blood and spleen but not in the pancreatic lymph nodes
Data suggest that a gain-of-function of human PTPN22 transgene encoding the tyrosine phosphatase LYP is unlikely to increase risk of autoimmunity through alterations of thymic selection.
PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens.
These data support that PTPN22 1858C/T, PTPRJ (show PTPRJ ELISA Kits) 2965C/G and 1176 A/C polymorphisms and ACP1 A (show ACP1 ELISA Kits), B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults.
this study reveals that the +1858T allele in the PTPN22 gene is associated with Rheumatoid Arthritis and Celiac Disease in a population from the south-west of Iran.
PTPN22 Gene Polymorphism rs1310182 has a role in juvenile idiopathic arthritis
The functional PTPN22 C1858T polymorphism was associated with an increased risk for Rheumatoid arthritis in the Mexican population.
this study shows that PTPN22 contributes to rheumatoid arthritis susceptibility in Egyptians
this study shows that PTPN22 gene polymorphism is associated wit the risk of allergic rhinitis in China
this study shows that PTPN22 polymorphism is associated with susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura
In conclusion, the authors found a lack of association of PTPN22 -1123G>C and +1858C>T polymorphisms with the risk of developing systemic lupus erythematosus in a Mexican population.
this study shows that PTPN22 genetic polymorphisms play role in predisposition of type 1 diabetes mellitus in Egyptian children
Results do not support a major role of PTPN22 gene SNPs in Behcet's disease in Spanish population.
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase