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anti-Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Antibodies

The protein encoded by TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. Additionally we are shipping TDP1 Proteins (9) and TDP1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TDP1 55775 Q9NUW8
TDP1 104884  
TDP1 314380 Q4G056
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Top anti-TDP1 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged TDP1 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$357.00
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TDP1. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Tdp1 AntibodyTitration: 1.0 µg/mL  Positive Control: Mouse Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (92.99 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB TDP1 Antibody (Center)  western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the TDP1 antibody detected the TDP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Human Placenta (formalin-fixed, paraffin-embedded) stained with  antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Small Intestine (formalin-fixed, paraffin-embedded) stained with  antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed A431, using TDP1, antibody at 1:200 dilution. IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric, using TDP1, antibody at 1:100 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details

TDP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-TDP1 Antibodies

  1. Human Polyclonal TDP1 Primary Antibody for ELISA, WB - ABIN565920 : Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. in The EMBO journal 2007 (PubMed)
    Show all 5 references for ABIN565920

  2. Human Monoclonal TDP1 Primary Antibody for ELISA, WB - ABIN393275 : Dexheimer, Stephen, Fivash, Fisher, Pommier: The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase. in Nucleic acids research 2010 (PubMed)
    Show all 5 references for ABIN393275

  3. Human Monoclonal TDP1 Primary Antibody for EIA, IHC (p) - ABIN400858 : Dexheimer, Antony, Marchand, Pommier: Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy. in Anti-cancer agents in medicinal chemistry 2008 (PubMed)
    Show all 2 references for ABIN400858

More Antibodies against TDP1 Interaction Partners

Arabidopsis thaliana Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. AtTDP plays a clear role in the repair of topoisomerase I (show TOP1 Antibodies)-DNA complexes.

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. The data obtained suggest that PARP1 (show PARP1 Antibodies) and TDP1 bind in an antiparallel orientation; the N-terminus of the former protein interacts with the C-terminal domain of the latter.

  2. Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells.

  3. varying expression levels of TOP1 (show TOP1 Antibodies) and TDP1 polypeptides in multiple colorectal cancer cell lines and in clinical colorectal cancer samples, are reported.

  4. both TOP1 (show TOP1 Antibodies) and TDP1 were upregulated in the tumor tissue compared to the adjacent non-tumor tissue in non-small cell lung cancer tissue

  5. Density functional theory computations are used to acquire thermodynamic and kinetic data along the catalytic pathway, including the phosphoryl transfers of Tdp1 and subsequent hydrolysis.

  6. TDP1 plays a role during the early stages of mammalian NHEJ. TPD1 stimulated DNA binding by XLF. TDP1 also promoted DNA binding by Ku70/80 and stimulated DNA-PK activity.

  7. These findings suggest that the flexibility of Tdp1 active site residues may impair the resolution of mutant Tdp1 covalent phosphohistidyl intermediates

  8. This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 and TDP2 (show TDP2 Antibodies), as well as the relevance of TDP1 and TDP2 (show TDP2 Antibodies) as determinants of response to anticancer agents

  9. TDP1 and APTX (show APTX Antibodies) take part in the mitochondrial DNA repair and are apparently being transported from the cell nucleus. (Review)

  10. Data provides insights into the possible inactivation of TDP1 in cancers and its relationship to cellular response to Top1 (show TOP1 Antibodies)-targeted drugs.

Mouse (Murine) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

  2. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.

  3. Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1 (show TOP1 Antibodies))-associated DNA strand breaks.

  4. This study provides a direct demonstration that Tdp1 repairs Topo I (show TOP1 Antibodies) covalent lesions in vivo and suggests that spinocerebellar ataxia (show USP14 Antibodies) with axonal neuropathy (SCAN1 (show CANT1 Antibodies)) arises from the recessive neomorphic mutation H493R.

  5. Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3'-phosphotyrosyl single-strand breaks and 3'-phosphoglycolate double-strand breaks, but not 3 (show CNOT3 Antibodies)'-phosphoglycolate single-strand breaks.

TDP1 Antigen Profile

Protein Summary

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Gene names and symbols associated with TDP1

  • tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10) antibody
  • tyrosyl-DNA phosphodiesterase (Tdp1) (Tc00.1047053506619.40) antibody
  • tyrosyl-DNA phosphodiesterase 1 (TDP1) antibody
  • tyrosyl-DNA phosphodiesterase 1 (tdp1) antibody
  • tyrosyl-DNA phosphodiesterase 1 (PTRG_11198) antibody
  • tyrosyl-DNA phosphodiesterase 1 (MCYG_02121) antibody
  • tyrosyl-DNA phosphodiesterase 1 (MGYG_03035) antibody
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1) antibody
  • 2810481F14Rik antibody
  • 4921509N21Rik antibody
  • AI838772 antibody
  • AW493413 antibody
  • E430034L06Rik antibody
  • F8M21.60 antibody
  • F8M21_60 antibody
  • MGC83708 antibody
  • MLZ-501 antibody
  • SCAN1 antibody
  • TDP1 antibody
  • tyrosyl-DNA phosphodiesterase 1 antibody

Protein level used designations for TDP1

tyrosyl-DNA Phosphodiesterase (Tdp1) , tyrosyl-DNA phosphodiesterase (Tdp1) , tyrosyl-DNA phosphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1-like , tyr-DNA phosphodiesterase 1 , protein expressed in male leptotene and zygotene spermatocytes 501 , tyrosyl-DNA phodphodiesterase 1

GENE ID SPECIES
3534433 Trypanosoma cruzi strain CL Brener
3543870 Trypanosoma cruzi strain CL Brener
423403 Gallus gallus
446983 Xenopus laevis
453096 Pan troglodytes
517053 Bos taurus
571485 Danio rerio
695338 Macaca mulatta
734106 Xenopus (Silurana) tropicalis
831369 Arabidopsis thaliana
6349511 Pyrenophora tritici-repentis Pt-1C-BFP
9229242 Arthroderma otae CBS 113480
10030819 Arthroderma gypseum CBS 118893
100388128 Callithrix jacchus
100432320 Pongo abelii
100593301 Nomascus leucogenys
55775 Homo sapiens
104884 Mus musculus
314380 Rattus norvegicus
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