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Tyrosyl-DNA Phosphodiesterase 1 Proteins (TDP1)

The protein encoded by TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. Additionally we are shipping TDP1 Antibodies (87) and TDP1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TDP1 55775 Q9NUW8
TDP1 104884  
TDP1 314380 Q4G056
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Top TDP1 Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,756.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TDP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced TDP1 Proteins

  1. Human TDP1 Protein expressed in Escherichia coli (E. coli) - ABIN1098766 : Heilig, Eckenberg, Petit, Fonknechten, Da Silva, Cattolico, Levy, Barbe, de Berardinis, Ureta-Vidal, Pelletier, Vico, Anthouard, Rowen, Madan, Qin, Sun, Du, Pepin, Artiguenave, Robert, Cruaud, Brüls et al.: The DNA sequence and analysis of human chromosome 14. ... in Nature 2003 (PubMed)
    Show all 2 references for ABIN1098766

  2. Human TDP1 Protein expressed in Wheat germ - ABIN1322434 : Takahashi, Tada, Igarashi, Koyama, Date, Yokoseki, Shiga, Yoshida, Tsuji, Nishizawa, Onodera: Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends. in Nucleic acids research 2007 (PubMed)

More Proteins for Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaction Partners

Arabidopsis thaliana Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. AtTDP plays a clear role in the repair of topoisomerase I (show TOP1 Proteins)-DNA complexes.

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. The data obtained suggest that PARP1 (show PARP1 Proteins) and TDP1 bind in an antiparallel orientation; the N-terminus of the former protein interacts with the C-terminal domain of the latter.

  2. Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells.

  3. varying expression levels of TOP1 (show TOP1 Proteins) and TDP1 polypeptides in multiple colorectal cancer cell lines and in clinical colorectal cancer samples, are reported.

  4. both TOP1 (show TOP1 Proteins) and TDP1 were upregulated in the tumor tissue compared to the adjacent non-tumor tissue in non-small cell lung cancer tissue

  5. Density functional theory computations are used to acquire thermodynamic and kinetic data along the catalytic pathway, including the phosphoryl transfers of Tdp1 and subsequent hydrolysis.

  6. TDP1 plays a role during the early stages of mammalian NHEJ. TPD1 stimulated DNA binding by XLF. TDP1 also promoted DNA binding by Ku70/80 and stimulated DNA-PK activity.

  7. These findings suggest that the flexibility of Tdp1 active site residues may impair the resolution of mutant Tdp1 covalent phosphohistidyl intermediates

  8. This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 and TDP2 (show TDP2 Proteins), as well as the relevance of TDP1 and TDP2 (show TDP2 Proteins) as determinants of response to anticancer agents

  9. TDP1 and APTX (show APTX Proteins) take part in the mitochondrial DNA repair and are apparently being transported from the cell nucleus. (Review)

  10. Data provides insights into the possible inactivation of TDP1 in cancers and its relationship to cellular response to Top1 (show TOP1 Proteins)-targeted drugs.

Mouse (Murine) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

  2. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.

  3. Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1 (show TOP1 Proteins))-associated DNA strand breaks.

  4. This study provides a direct demonstration that Tdp1 repairs Topo I (show TOP1 Proteins) covalent lesions in vivo and suggests that spinocerebellar ataxia (show USP14 Proteins) with axonal neuropathy (SCAN1 (show CANT1 Proteins)) arises from the recessive neomorphic mutation H493R.

  5. Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3'-phosphotyrosyl single-strand breaks and 3'-phosphoglycolate double-strand breaks, but not 3 (show CNOT3 Proteins)'-phosphoglycolate single-strand breaks.

TDP1 Protein Profile

Protein Summary

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Gene names and symbols associated with TDP1

  • tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10)
  • tyrosyl-DNA phosphodiesterase (Tdp1) (Tc00.1047053506619.40)
  • tyrosyl-DNA phosphodiesterase 1 (TDP1)
  • tyrosyl-DNA phosphodiesterase 1 (tdp1)
  • tyrosyl-DNA phosphodiesterase 1 (PTRG_11198)
  • tyrosyl-DNA phosphodiesterase 1 (MCYG_02121)
  • tyrosyl-DNA phosphodiesterase 1 (MGYG_03035)
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1)
  • 2810481F14Rik protein
  • 4921509N21Rik protein
  • AI838772 protein
  • AW493413 protein
  • E430034L06Rik protein
  • F8M21.60 protein
  • F8M21_60 protein
  • MGC83708 protein
  • MLZ-501 protein
  • SCAN1 protein
  • TDP1 protein
  • tyrosyl-DNA phosphodiesterase 1 protein

Protein level used designations for TDP1

tyrosyl-DNA Phosphodiesterase (Tdp1) , tyrosyl-DNA phosphodiesterase (Tdp1) , tyrosyl-DNA phosphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1-like , tyr-DNA phosphodiesterase 1 , protein expressed in male leptotene and zygotene spermatocytes 501 , tyrosyl-DNA phodphodiesterase 1

GENE ID SPECIES
3534433 Trypanosoma cruzi strain CL Brener
3543870 Trypanosoma cruzi strain CL Brener
423403 Gallus gallus
446983 Xenopus laevis
453096 Pan troglodytes
517053 Bos taurus
571485 Danio rerio
695338 Macaca mulatta
734106 Xenopus (Silurana) tropicalis
831369 Arabidopsis thaliana
6349511 Pyrenophora tritici-repentis Pt-1C-BFP
9229242 Arthroderma otae CBS 113480
10030819 Arthroderma gypseum CBS 118893
100388128 Callithrix jacchus
100432320 Pongo abelii
100593301 Nomascus leucogenys
55775 Homo sapiens
104884 Mus musculus
314380 Rattus norvegicus
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