Tyrosyl-tRNA Synthetase (Yars) ELISA Kits

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Additionally we are shipping Tyrosyl-tRNA Synthetase Antibodies (68) and Tyrosyl-tRNA Synthetase Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human Yars Yars 8565 P54577
Anti-Mouse Yars Yars 107271 Q91WQ3
Anti-Rat Yars Yars 313047 Q4KM49
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More ELISA Kits for Tyrosyl-tRNA Synthetase Interaction Partners

Fruit Fly (Drosophila melanogaster) Tyrosyl-tRNA Synthetase (Yars) interaction partners

  1. This study showed that show that apoptotic loser cells secrete Tyrosyl-tRNA synthetase, which is best known as a core component of the translational machinery.

  2. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.

Human Tyrosyl-tRNA Synthetase (Yars) interaction partners

  1. These YARS variants occur in the catalytic domain and the C-terminal domain, respectively. Mutations in YARS have been previously associated with an autosomal dominant form of Charcot-Marie-Tooth (CMT); our findings suggest the disease spectrum associated with YARS dysregulation is broader than peripheral neuropathy.

  2. Studied the structural effect of three Charcot-Marie-Tooth disease-causing mutations in tyrosyl-tRNA synthetase. The mutations do not induce changes in protein secondary structures, or shared effects on oligomerization state and stability. However, all mutations provide access to a surface masked in the wild-type enzyme, and that access correlates with protein misinteraction.

  3. Data show that the internal deletion of tyrosyl-tRNA synthetase TyrRSDeltaE2-4 splice variants (SVs (show FGFR2 ELISA Kits)) gave an alternative, neomorphic dimer interface 'orthogonal' to that of native TyrRS.

  4. Expression of CMT-mutant tyrosyl-tRNA synthetase in Drosophila impairs protein translation.

  5. Computational modeling of molecular dynamics of G41R mutant form of human tyrosyl-tRNA synthetase, assosiated with Charcot-Marie-Tooth neuropathy has been presented.

  6. the association of rare YARS variant with late-onset autosomal dominant Charcot-Marie-Tooth neuropathy

  7. nuclear-localized TyrRS activates transcription factor E2F1 (show E2F1 ELISA Kits) to upregulate the expression of DNA damage repair genes such as BRCA1 and RAD51 (show RAD51 ELISA Kits).

  8. A major difference between the first- and second-generation tRNA synthetases (RSs (show GRB10 ELISA Kits)) is that the second-generation RSs (show GRB10 ELISA Kits) have an active site more compatible with tyrosine binding.

  9. The full length tyrosyl-tRNA synthetase lacks its cytokine activity because of the interactions between N-terminal and the C-terminal modules, which protect the ELR cytokine motif.

  10. Naturally occurring fragments of the two proteins involved in translation, TyrRS and TrpRS (show WARS ELISA Kits), have opposing activities on angiogenesis.

Cow (Bovine) Tyrosyl-tRNA Synthetase (Yars) interaction partners

Tyrosyl-tRNA Synthetase (Yars) Antigen Profile

Antigen Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.

Gene names and symbols associated with Yars

  • tyrosyl-tRNA synthetase (yars) antibody
  • tyrosyl-tRNA synthetase (YARS) antibody
  • tyrosyl-tRNA synthetase, putative (MAL8P1.125) antibody
  • tyrosine--tRNA ligase (MEFER_RS04475) antibody
  • Tyrosyl-tRNA synthetase (TyrRS) antibody
  • tyrosine--tRNA ligase, cytoplasmic (LOC413909) antibody
  • tyrosyl-tRNA synthetase (tyrS) antibody
  • tyrosine--tRNA ligase, cytoplasmic (LOC100163888) antibody
  • tyrosyl-tRNA synthetase (LOC100282315) antibody
  • tyrosyl-tRNA synthetase (Yars) antibody
  • tyrosyl-tRNA synthetase L homeolog (yars.L) antibody
  • AL024047 antibody
  • anon-EST:Posey261 antibody
  • AU018965 antibody
  • cb204 antibody
  • CG4561 antibody
  • CMTDIC antibody
  • Dmel\\CG4561 antibody
  • dYARS antibody
  • ECK1633 antibody
  • GB10789 antibody
  • JW1629 antibody
  • TYRRS antibody
  • wu:fk52b08 antibody
  • YARS antibody
  • YRS antibody
  • YTS antibody

Protein level used designations for Yars

tyrosine--tRNA ligase, cytoplasmic , tyrosyl--tRNA ligase , tyrosyl-tRNA synthetase, cytoplasmic , tyrosyl-tRNA synthetase , Tyrosyl-tRNA synthetase, cytoplasmic , tyrRS , Aats-tyr-PA , CG4561-PA , ACYPI004940 , tyrosine tRNA ligase 1, cytoplasmic

448444 Xenopus (Silurana) tropicalis
469266 Pan troglodytes
709003 Macaca mulatta
2655248 Plasmodium falciparum 3D7
8365568 Methanocaldococcus fervens AG86
100173008 Pongo abelii
39829 Drosophila melanogaster
413909 Apis mellifera
948855 Escherichia coli str. K-12 substr. MG1655
1445173 Aeropyrum pernix K1
100163888 Acyrthosiphon pisum
100282315 Zea mays
368235 Danio rerio
419666 Gallus gallus
8565 Homo sapiens
478148 Canis lupus familiaris
281581 Bos taurus
107271 Mus musculus
313047 Rattus norvegicus
380438 Xenopus laevis
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