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U2 Small Nuclear RNA Auxiliary Factor 1 Proteins (U2AF1)

U2AF1 belongs to the splicing factor SR family of genes. Additionally we are shipping U2AF1 Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
U2AF1 108121 Q9D883
U2AF1 7307 Q01081
Rat U2AF1 U2AF1 687575  
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Top U2AF1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,115.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,597.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details

U2AF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) Interaction Partners

Mouse (Murine) U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) interaction partners

  1. data support the impact of genes from the Abcg1 (show ABCG1 Proteins)-U2af1 region as modifiers of Tc1 (show C8orf4 Proteins)-dependent memory and locomotor phenotypes in Tc1 (show C8orf4 Proteins) mouse model of Down syndrome.

  2. findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS (show MECOM Proteins)

  3. this study establishes definitely the contribution of the Abcg1 (show ABCG1 Proteins)-U2af1 orthologous region to the DS etiology and suggests new modulatory pathways for learning and memory.

Human U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) interaction partners

  1. In multivariate analysis, U2AF1 and TP53 (show TP53 Proteins) mutations retained independent prognostic significance across 93 cases of acute myeloid leukemia (show BCL11A Proteins)

  2. The mutational status of the SRSF2 (show SRSF2 Proteins), U2AF1 and ZRSR2 (show ZRSR2 Proteins) did not affect the response rate or survival in MDS (show PAFAH1B1 Proteins) patients who had received first-line decitabine treatment.

  3. A mutant U2AF1 (S34F) found in a variety of cancer types results in delayed splicing and disruption of kinetic competition during transcription.

  4. The S34F mutation alters U2AF1 function in the context of specific RNA sequences, leading to aberrant alternative splicing of target genes, some of which may be relevant for myelodysplastic syndromes pathogenesis.

  5. Molecular monitoring of patients having undergone AHSCT for PMF (show PRB1 Proteins) should not be restricted to JAK2 (show JAK2 Proteins), MPL (show MPL Proteins) or CALR (show CALR Proteins), but all mutations present in primary fibrotic neoplastic myeloproliferation should be included to interpret abnormal blood values after AHSCT

  6. Data indicate somatic mutations in the splicing factor (show SLU7 Proteins) U2AF1 across 12 cancer types.

  7. study describes incidence and phenotypic and prognostic relevance of U2AF1 mutations in primary myelofibrosis(PMF (show PRB1 Proteins)); U2AF1 mutations cluster with JAK2V617F, ASXL1 (show ASXL1 Proteins) mutations and normal karyotype; U2AF1 mutations are strongly and inter-independently associated with anemia and thrombocytopenia

  8. genetic association studies in a population in Taiwan: Data suggest that U2AF1 mutations are associated with poor prognosis/survival in patients with myelodysplastic syndrome and shorter time-to-leukemia transformation in young patients.

  9. U2AF1 mutations play a significant role in myeloid leukemogenesis due to selective missplicing of tumor-associated genes

  10. data suggest that SF3B1 (show SF3B2 Proteins), U2AF1 and SRSF2 (show SRSF2 Proteins) mutations occur not only in myeloid lineage tumors but also in lymphoid lineage tumors; data suggest that the splicing gene mutations play important roles in the pathogenesis of hematologic tumors, but rarely in solid tumors

U2AF1 Protein Profile

Protein Summary

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with U2AF1

  • U2 small nuclear RNA auxiliary factor 1 (U2AF1)
  • CCHC-type zinc finger-containing protein (u2af1)
  • U2 small nuclear RNA auxiliary factor 1 (u2af1)
  • U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 (U2af1)
  • U2 small nuclear RNA auxiliary factor 1 (U2af1)
  • U2(RNU2) small nuclear RNA auxiliary factor 1 (u2af1)
  • 35kDa protein
  • 2010107D16Rik protein
  • CHUNP6860 protein
  • DDBDRAFT_0218665 protein
  • DDBDRAFT_0233354 protein
  • DDB_0218665 protein
  • DDB_0233354 protein
  • FP793 protein
  • RN protein
  • RNU2AF1 protein
  • U2AF35 protein
  • U2AFBP protein
  • zgc:111896 protein

Protein level used designations for U2AF1

U2 small nuclear RNA auxiliary factor 1 , RNA recognition motif-containing protein RRM , RNA-binding region RNP-1 domain-containing protein , U2 snRNP auxiliary factor small subunit , U2(RNU2) small nuclear RNA auxiliary factor 1 , U2 auxiliary factor 35 kDa subunit , U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa , splicing factor U2AF 35 kDa subunit , U2 small nuclear RNA auxillary factor 1 , U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit , U2(RNU2) small nuclear RNA auxiliary factor binding protein , splicing factor U2AF 35kDa subunit , U2snRNP auxiliary factor small subunit , uncharacterized protein LOC687575 , U2(RNU2) small nuclear RNA auxillary factor 1

GENE ID SPECIES
478422 Canis lupus familiaris
8624909 Dictyostelium discoideum AX4
733934 Xenopus (Silurana) tropicalis
737227 Pan troglodytes
108121 Mus musculus
7307 Homo sapiens
734926 Xenopus laevis
395370 Gallus gallus
512680 Bos taurus
687575 Rattus norvegicus
192328 Danio rerio
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