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U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) ELISA Kits

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. Additionally we are shipping U2 Small Nuclear RNA Auxiliary Factor 2 Antibodies (49) and U2 Small Nuclear RNA Auxiliary Factor 2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse U2AF59 U2AF59 22185 P26369
Anti-Human U2AF59 U2AF59 11338 P26368
Anti-Rat U2AF59 U2AF59 308335  
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More ELISA Kits for U2 Small Nuclear RNA Auxiliary Factor 2 Interaction Partners

Mouse (Murine) U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) interaction partners

  1. Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA tox (show NXF1 ELISA Kits)icity in polyQ diseases.

  2. dephosphorylation of pS776-ATXN1 (show ATXN1 ELISA Kits) by PP2A regulates the interaction of ATXN1 (show ATXN1 ELISA Kits) with the splicing factors RBM17 (show RBM17 ELISA Kits) and U2AF65

  3. Using a yeast two-hybrid system, we found fourteen U2AF(65)-interacting proteins. The validity of the screen was confirmed by identification of five known U2AF(65)-interacting proteins, including its heterodimeric partner, U2AF(35 (show U2AF1 ELISA Kits)).

Xenopus laevis U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) interaction partners

  1. In vivo binding of U2AF(65) to a polypyrimidine tract requires a flexible RNA backbone.

Human U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) interaction partners

  1. The U2AF(65) linker residues between the dual RNA recognition motifs (RRMs) recognize the central nucleotide, whereas the N- and C-terminal RRM extensions recognize the 3' terminus and third nucleotide.

  2. Nuclear retention of full-length HTT (show HTT ELISA Kits) RNA is mediated by splicing factors MBNL1 and U2AF65

  3. U2AF(65) possesses a splicing Inhibitory function that leads to alternative exon skipping.

  4. The spatial distribution of U2AF65 conformations is found to be highly anisotropic, comprising significantly populated interdomain contacts that appear to be electrostatic in origin.

  5. reduced U2AF(65) binding is a molecular consequence of disease-relevant mutations, and a structure-guided U2AF(65) variant is capable of manipulating gene expression in eukaryotic cells

  6. We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65

  7. U2AF65 represents a new route for modulating TRF1 (show TERF1 ELISA Kits) function at telomeres.

  8. The conserved SPSP motif phosphorylation and the SF1 (show NR5A1 ELISA Kits)/U2AF interface are essential in vivo.

  9. The results highlight both local and global conformational selection as a means for universal 3' splice site recognition by U2AF65.

  10. The REST N exon is a very versatile sequence with a complex array of splicing signals, and its activation in H69 cells depends on the relative amounts of hnRNP H (show HNRNPH1 ELISA Kits) and U2AF65.

U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) Antigen Profile

Antigen Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.

Gene names and symbols associated with U2AF59

  • U2 small nuclear RNA auxiliary factor 2 (u2af2) antibody
  • U2 small nuclear RNA auxiliary factor 2 (U2AF2) antibody
  • RNA recognition motif-containing protein RRM (u2af2) antibody
  • Splicing factor U2AF 65 kDa subunit (u2af2) antibody
  • U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 (U2af2) antibody
  • U2 small nuclear RNA auxiliary factor 2 (U2af2) antibody
  • 65kDa antibody
  • DDBDRAFT_0186947 antibody
  • DDBDRAFT_0233353 antibody
  • DDB_0186947 antibody
  • DDB_0233353 antibody
  • U2AF2 antibody
  • U2AF65 antibody

Protein level used designations for U2AF59

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 , U2 small nuclear RNA auxiliary factor 2 , RNA-binding region RNP-1 domain-containing protein , U2 snRNP auxiliary factor large subunit , Splicing factor U2AF 65 kDa subunit , U2 auxiliary factor 65 kDa subunit , U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa , splicing factor U2AF 65 kDa subunit , splicing factor U2AF large chain , U2 (RNU2) small nuclear RNA auxiliary factor 2 , U2 small nuclear ribonucleoprotein auxiliary factor (65kD) , hU2AF65

GENE ID SPECIES
549752 Xenopus (Silurana) tropicalis
703269 Macaca mulatta
8625590 Dictyostelium discoideum AX4
100380519 Salmo salar
22185 Mus musculus
380287 Xenopus laevis
11338 Homo sapiens
100687048 Canis lupus familiaris
507895 Bos taurus
308335 Rattus norvegicus
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