U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) ELISA Kits

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. Additionally we are shipping U2 Small Nuclear RNA Auxiliary Factor 2 Antibodies (58) and U2 Small Nuclear RNA Auxiliary Factor 2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse U2AF59 U2AF59 22185 P26369
Anti-Human U2AF59 U2AF59 11338 P26368
Anti-Rat U2AF59 U2AF59 308335  
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More ELISA Kits for U2 Small Nuclear RNA Auxiliary Factor 2 Interaction Partners

Mouse (Murine) U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) interaction partners

  1. Perturbation of U2AF65/NXF1 (show NXF1 ELISA Kits)-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.

  2. dephosphorylation of pS776-ATXN1 (show ATXN1 ELISA Kits) by PP2A regulates the interaction of ATXN1 (show ATXN1 ELISA Kits) with the splicing factors RBM17 (show RBM17 ELISA Kits) and U2AF65

  3. Using a yeast two-hybrid system, we found fourteen U2AF(65)-interacting proteins. The validity of the screen was confirmed by identification of five known U2AF(65)-interacting proteins, including its heterodimeric partner, U2AF(35 (show U2AF1 ELISA Kits)).

Xenopus laevis U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) interaction partners

  1. In vivo binding of U2AF(65) to a polypyrimidine tract requires a flexible RNA backbone.

Human U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) interaction partners

  1. RBM39 (show RBM39 ELISA Kits) is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 (show RBM39 ELISA Kits) may modulate alternative splicing similarly to U2AF65 by either directly binding to RNA or recruiting other splicing factors, such as U2AF65.

  2. These findings uncovered a hitherto unappreciated function of CD82 (show CD82 ELISA Kits) in severing the linkage between U2AF2-mediated CD44 (show CD44 ELISA Kits) alternative splicing and cancer aggressiveness, with potential prognostic and therapeutic implications in melanoma

  3. JMJD6 (show JMJD6 ELISA Kits) regulated a large set of alternative splicing events, and importantly, its regulated splicing events were significantly overlapped those controlled by U2AF65.

  4. This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35 (show U2AF1 ELISA Kits), U2AF65, RBM39 (show RBM39 ELISA Kits) and SF3b155 (show SF3B1 ELISA Kits), and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.

  5. The U2AF(65) linker residues between the dual RNA recognition motifs (RRMs) recognize the central nucleotide, whereas the N- and C-terminal RRM extensions recognize the 3' terminus and third nucleotide.

  6. Nuclear retention of full-length HTT (show HTT ELISA Kits) RNA is mediated by splicing factors MBNL1 (show MBNL1 ELISA Kits) and U2AF65

  7. U2AF(65) possesses a splicing Inhibitory function that leads to alternative exon skipping.

  8. The spatial distribution of U2AF65 conformations is found to be highly anisotropic, comprising significantly populated interdomain contacts that appear to be electrostatic in origin.

  9. reduced U2AF(65) binding is a molecular consequence of disease-relevant mutations, and a structure-guided U2AF(65) variant is capable of manipulating gene expression in eukaryotic cells

  10. We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65

U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) Antigen Profile

Antigen Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.

Gene names and symbols associated with U2AF59

  • U2 small nuclear RNA auxiliary factor 2 (u2af2) antibody
  • U2 small nuclear RNA auxiliary factor 2 (U2AF2) antibody
  • RNA recognition motif-containing protein RRM (u2af2) antibody
  • Splicing factor U2AF 65 kDa subunit (u2af2) antibody
  • U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 (U2af2) antibody
  • U2 small nuclear RNA auxiliary factor 2 (U2af2) antibody
  • 65kDa antibody
  • DDBDRAFT_0186947 antibody
  • DDBDRAFT_0233353 antibody
  • DDB_0186947 antibody
  • DDB_0233353 antibody
  • U2AF2 antibody
  • U2AF65 antibody

Protein level used designations for U2AF59

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 , U2 small nuclear RNA auxiliary factor 2 , RNA-binding region RNP-1 domain-containing protein , U2 snRNP auxiliary factor large subunit , Splicing factor U2AF 65 kDa subunit , U2 auxiliary factor 65 kDa subunit , U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa , splicing factor U2AF 65 kDa subunit , splicing factor U2AF large chain , U2 (RNU2) small nuclear RNA auxiliary factor 2 , U2 small nuclear ribonucleoprotein auxiliary factor (65kD) , hU2AF65

GENE ID SPECIES
549752 Xenopus (Silurana) tropicalis
703269 Macaca mulatta
8625590 Dictyostelium discoideum AX4
100380519 Salmo salar
22185 Mus musculus
380287 Xenopus laevis
11338 Homo sapiens
100687048 Canis lupus familiaris
507895 Bos taurus
308335 Rattus norvegicus
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