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UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 Proteins (B4GALT1)

B4GALT1 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. Additionally we are shipping B4GALT1 Antibodies (35) and B4GALT1 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
B4GALT1 2683 P15291
B4GALT1 14595 P15535
Rat B4GALT1 B4GALT1 24390  
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Top B4GALT1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

B4GALT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

Top referenced B4GALT1 Proteins

  1. Human B4GALT1 Protein expressed in Human Cells - ABIN2004114 : Ortez: On the relationship between inflammation and altered cAMP metabolism in lungs of B pertussis-vaccinated mice. in Inflammation 1978 (PubMed)
    Show all 2 references for ABIN2004114

More Proteins for UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) Interaction Partners

Human UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) interaction partners

  1. We suggest that the unique expression patterns for the B4GALT1 in normal and malignant tissues are controlled by a differential usage of 5'-B4GALT1 regulatory units along with a post-transcriptional regulation by the antisense RNA

  2. Human chorionic gonadotropin provides a mechanism to bridge embryo to endometrium through beta1,4-GalT (show GALT Proteins).

  3. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 (show MGAT3 Proteins) whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc.

  4. B4GALT1 and B4GALT5 (show B4GALT5 Proteins), two members of B4GALT (show B4GALNT2 Proteins) gene family, are involved in the development of multidrug resistance of human leukemia cells.

  5. the glycogene B4GALT1 represent a valuable candidate biomarker of invasive phenotype of colorectal cancer.

  6. RNAi-mediated knockdown of beta1,4GT1 increased the levels of EGFR (show EGFR Proteins) dimerization and phosphorylation. These data suggest that cell surface beta1,4GT1 interacts with EGFR (show EGFR Proteins) and inhibits EGFR (show EGFR Proteins) activatio

  7. estrogen regulates the expression of B4GALT1 through the direct binding of ER-alpha (show ESR1 Proteins) to ERE; the expressed B4GALT1 plays a crucial role in the proliferation of MCF-7 cells through its activity as a membrane receptor.

  8. Osteopontin (show SPP1 Proteins) increases the expression of beta1, 4-Galactosyltransferase-I (show B4GALT7 Proteins) and promotes adhesion in human RL95-2 cells, the activity critical for embryo implantation.

  9. expression of beta1,4-GalT (show GALT Proteins)-I increased in the cartilage and synovial tissue of osteoarthritis (OA) patients compared with healthy controls; data suggest that beta1,4-GalT (show GALT Proteins)-I may play an important role in the inflammatory processes in cartilage and synovial tissue of patients with OA

  10. beta4Gal-T1 molecule has two different oligosaccharide binding regions for the binding of the extended oligosaccharide moiety of the acceptor substrate.

Mouse (Murine) UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) interaction partners

  1. Beta 1,4-galactosyltransferase I (show B4GALT7 Proteins) possibly regulate mutual uterus-embryo adhesion and embryo implantation by regulating cell surface Le(Y) glycan expression.

  2. revealed increased expression of polylactosamines on B4galt1(+/-) B cells and macrophages, compared with B4galt1(+/+) cells

  3. beta4GalT-I is a major galactosyltransferase responsible for selectin-ligand biosynthesis and that inflammatory responses of beta4GalT-I-deficient mice are impaired because of the defect in selectin-ligand biosynthesis.

  4. the beta4-galactosyltransferase-1 coding sequence does not contain functional elements that affect the intrinsic stability of this mRNA

  5. regulation of expression by focal adhesion kinase

  6. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.

Cow (Bovine) UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) interaction partners

  1. Hypothesized that engineering B4GALT1 to block cleavage and secretion would enhance its retention and its function; to test this hypothesis, replaced CTS (show TTR Proteins) domains of bovine B4GALT1 with those from human FUT7 (show FUT7 Proteins), which is not cleaved and secreted.

  2. Crystal structure of mutant Met344His beta4Gal-T1 defined at 2.3 angstrom resolution reveals that the N-acetylglucosamine residue at nonreducing end of chitobiose makes extensive hydrophobic interactions with highly conserved tyrosine-286 of beta4Gal-T1.

B4GALT1 Protein Profile

Protein Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.

Gene names and symbols associated with B4GALT1

  • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4GALT1)
  • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1)
  • B-1,4-GalT protein
  • B-1,4-GalT1 protein
  • b4Gal-T1 protein
  • beta-1,4-GalT protein
  • beta-1,4-GalT1 protein
  • beta4Gal-T1 protein
  • CDG2D protein
  • GalT protein
  • Ggtb protein
  • Ggtb2 protein
  • GT1 protein
  • GTB protein

Protein level used designations for B4GALT1

UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 , UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 , beta-1,4-GalTase 1 , beta-1,4-galactosyltransferase 1 , glycoprotein-4-beta-galactosyltransferase 2 , lactose synthase , b1,4-Galactosyltransferase I , galactosyltransferase 2 beta 1, 4 , glycoprotein galactosyltransferase beta 1, 4 , Glycoprotein-4-beta-galactosyltransferase 2 , b4Gal-T1 , beta4Gal-T1 , beta-galactosyltransferase 2 (glycoprotein) , UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

GENE ID SPECIES
2683 Homo sapiens
14595 Mus musculus
24390 Rattus norvegicus
281781 Bos taurus
100345726 Oryctolagus cuniculus
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