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UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 12 (GalNAc-T12) Proteins (GALNT12)

GALNT12 encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Additionally we are shipping GALNT12 Antibodies (10) and GALNT12 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GALNT12 230145 Q8BGT9
GALNT12 79695 Q8IXK2
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Top GALNT12 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

GALNT12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 12 (GalNAc-T12) (GALNT12) Interaction Partners

Human UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 12 (GalNAc-T12) (GALNT12) interaction partners

  1. Results rule out GALNT12 as a major high familial colorectal cancer susceptibility gene. Additional studies are required to provide further evidence about its role as a moderate/low susceptibility gene in familial aggregation of cancer.

  2. we integrated different computational tools to perform the in silico analysis of clinically significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3 (show GALNT3 Proteins), GALNT8 (show GALNT8 Proteins), GALNT12, and GALNT13 (show GALNT13 Proteins) genes.

  3. Inherited deleterious variants in GALNT12 are associated with CRC (show CALR Proteins) susceptibility.

  4. The expression of pp-GalNAc-T12 seems to be a negative marker especially of metastatic gastric and colorectal cancer

  5. inactivating GALNT12 mutations were identified as acquired somatic mutations in a set of 30 microsatellite stable colon tumors.

GALNT12 Protein Profile

Protein Summary

This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.

Gene names and symbols associated with GALNT12

  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (Galnt12)
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) (GALNT12)
  • 9130206E10 protein
  • A630062B03Rik protein
  • CRCS1 protein
  • GalNAc-T12 protein

Protein level used designations for GALNT12

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 , galNAc-T12 , mpp-GalNAc-T12 , polypeptide GalNAc transferase 12 , polypeptide N-acetylgalactosaminyltransferase 12 , pp-GaNTase 12 , protein-UDP acetylgalactosaminyltransferase 12 , colorectal cancer, susceptibility to 1

GENE ID SPECIES
230145 Mus musculus
79695 Homo sapiens
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