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GALNT12 encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Additionally we are shipping GALNT12 Antibodies (12) and GALNT12 Proteins (5) and many more products for this protein.
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LOH analyses, glycosylation pattern tests and case-control studies, our results did not support the role of c.907G>A, p.(D303N) as a high-penetrance risk allele for polyposis CRC (show CALR ELISA Kits)
Results rule out GALNT12 as a major high familial colorectal cancer susceptibility gene. Additional studies are required to provide further evidence about its role as a moderate/low susceptibility gene in familial aggregation of cancer.
we integrated different computational tools to perform the in silico analysis of clinically significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3 (show GALNT3 ELISA Kits), GALNT8, GALNT12, and GALNT13 (show GALNT13 ELISA Kits) genes.
Inherited deleterious variants in GALNT12 are associated with CRC (show CALR ELISA Kits) susceptibility.
The expression of pp-GalNAc-T12 seems to be a negative marker especially of metastatic gastric and colorectal cancer
inactivating GALNT12 mutations were identified as acquired somatic mutations in a set of 30 microsatellite stable colon tumors.
This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12
, polypeptide GalNAc transferase 12
, polypeptide N-acetylgalactosaminyltransferase 12
, pp-GaNTase 12
, protein-UDP acetylgalactosaminyltransferase 12
, colorectal cancer, susceptibility to 1