Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
GALNT6 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Additionally we are shipping GALNT6 Antibodies (60) and GALNT6 Proteins (7) and many more products for this protein.
This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6.
GalNAcT6 role in cancer [review]
Findings show that the expression of GalNAc-T6 in endometrial carcinoma is significantly related to E-cadherin (show CDH1 ELISA Kits) expression, and better prognosis and overall survival.
Study showed that GalNAc-T6 expression in epithelial ovarian carcinoma was different according to pathological type. In low-grade serous carcinoma, GalNAc-T6 expression may contribute to improved long-term survival.
GALNT6-induced O-glycosylation is critical for the stability, subcellular localization, and anti-apoptotic function of GRP78 (show HSPA5 ELISA Kits) protein in cancer cells. We also suggest that GRP78 (show HSPA5 ELISA Kits) might enhance the activity of GALNT6 in carcinogenesis through driving Golgi-to-ER relocation of GALNT6.
knockdown of GALNT6 caused drastic morphological changes of pancreatic cells, accompanied with the cadherin switching from P-cadherin to E-cadherin (show CDH1 ELISA Kits).
Role of N-acetylgalactosaminyltransferase (show B4GALNT2 ELISA Kits) 6 in early tumorigenesis and formation of metastasis.
These data suggest that excess O-glycosylation on APP (show APP ELISA Kits) by GalNAc-T6 inhibits Abeta (show APP ELISA Kits) production.
GALNT6-fibronectin (show FN1 ELISA Kits) pathway should be a critical component for breast cancer development and progression.
Expression of ppGalNAc-T6 is significantly higher in breast cancer compared to 'normal'/benign breast tissue samples. ST6GalNAc-I (show ST6GALNAC1 ELISA Kits) expression in breast cancer is associated with better prognosis.
These enzymes, xGalNAc-T6 and xGalNAc- T16 (show FBLN3 ELISA Kits), from different branches of the N-acetylgalactosaminyltransferase (show B4GALNT2 ELISA Kits) do not only display differential substrate specificities, but also specific and distinct expression pattern and biological activities in vivo.
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.
polypeptide N-acetylgalactosaminyltransferase 6
, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
, polypeptide GalNAc transferase 6
, pp-GaNTase 6
, protein-UDP acetylgalactosaminyltransferase 6
, N-acetylgalactosaminyltransferase T-6
, Protein-UDP acetylgalactosaminyltransferase 6
, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6
, GalNAc transferase 6
, UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6