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Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. Additionally we are shipping ULBP2 Antibodies (38) and ULBP2 Kits (26) and many more products for this protein.
Showing 8 out of 12 products:
Human ULBP2 Protein expressed in Human Cells - ABIN2005067
Cosman, Müllberg, Sutherland, Chin, Armitage, Fanslow, Kubin, Chalupny: ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. in Immunity 2001
Show all 2 references for ABIN2005067
By suppressing AR and up-regulating ULBP2 in HCC (show FAM126A Proteins), cisplatin could up-regulate cytotoxicity of NK cells to better target HCC (show FAM126A Proteins).
human tumor cells lost their surface expression of ULBP2, but not ULBP1 and ULBP3, during NK cell-mediated cytolysis.
This study suggests that NKG2D (show KLRK1 Proteins) ligands shedding of MICA (show MICA Proteins), MICB (show MICB Proteins) and ULBP-2 is a novel pathway in endometriosis complex pathogenesis that impairs Natural Killer Cells cell function.
Varicella-Zoster Virus differentially modulates expression of the NKG2D ligands by upregulating MICA expression and reducing ULBP2 and ULBP3 expression in the infected cells.
A conserved WW domain-like motif regulates CD74 (show CD74 Proteins) antigen-dependent cell-surface transport of the NKG2D (show KLRK1 Proteins) ligand ULBP2.
NKG2D (show KLRK1 Proteins) and NKG2DL are involved in allergen-induced activation of dendritic epidermal T cells and the NKG2D (show KLRK1 Proteins)/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity.
Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.
Data inticate that heat shock protein 60 (HSP60 (show HSPD1 Proteins)) interacted constitutively with NKG2D (show KLRK1 Proteins) ligand ULBP2 and phosphatase of regenerating liver 3 (PRL-3) regulated HSP60 (show HSPD1 Proteins) tyrosine phosphorylation.
Results suggest that ULBP2 is expressed and released from cervical cancer cells by CRF (show CRH Proteins), which regulates NKG2D (show KLRK1 Proteins) expression in natural killer cells.
c-Cbl (show CBL Proteins) regulates MICA (show MICA Proteins)- but not ULBP2-induced NKG2D (show KLRK1 Proteins) down-modulation in human NK cells.
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface.
, NKG2D ligand 2
, UL16-binding protein 2
, retinoic acid early transcript 1 H
, retinoic acid early transcript 1H