anti-UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Antibodies

UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UPF1 306350  
UPF1 5976 Q92900
UPF1 19704 Q9EPU0
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Top anti-UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of RENT1 (arrow) using rabbit polyclonal RENT1 Antibody (N-term) (ABIN388607). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the RENT1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated WB Detection of Human RENT1 by Western Blot. Samples: Whole cell lysate (30 mcg) from lymphoblastoid cell lines (EBV-immotalized B-cell from a normal individual). Antibody: Affinity purified goat anti-RENT1 antibody ABIN151832 used at 1 mcg/ml. Detection: Chemiluminescence. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Goat Un-conjugated PLA, WB Western Blot: RENT-1 Antibody [ABIN151834] - Detection of Human RENT-1 by Western Blot. Samples: Whole cell lysate (30 mcg) from lymphoblastoid cell lines (EBVimmotalized B-cell from a normal individual). Antibody: Affinity purified goat anti-RENT-1 antibody (Cat. No. ABIN151834) used at 1 mcg/ml. Detection: Chemiluminescence. Proximity Ligation Assay: RENT1/UPF1/hUPF1 Antibody [ABIN151834] - Secondary-conjugate Duolink II PLA in Hela cells. Goat anti-human RENT1 (ABIN151834) and rabbit anti-human ATR (ABIN151834). Image merged from DAPI (2ms) and Texas Red (200ms) exposoures, 40X magnification. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Goat Un-conjugated WB Detection of Human RENT1 by Western Blot. Samples: Whole cell lysate (30 mcg) from lymphoblastoid cell lines (EBV-immotalized B-cell from a normal individual). Antibody Affinity purified goat anti-RENT1 antibody ABIN151833 used at 1 mcg/ml. Detection: Chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated IP, PLA, WB Proximity Ligation Assay: RENT1/UPF1/hUPF1 Antibody [NBP1-05967] - Secondary-conjugate Duolink in Situ PLA in Hela cells. goat anti-human RelA (NBP2-22297) and rabbit anti-human RENT1/UPF1/hUPF1 (NBP1-05967). Image merged from DAPI (2ms), FITC/Green (25ms) and Red (200ms) exposures, 40X magnification. 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated WB Western blot analysis of RENT1 (arrow) using rabbit polyclonal RENT1 Antibody (N-term E22) (ABIN1882125) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the RENT1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details

UPF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Antibodies

  1. Human Polyclonal UPF1 Primary Antibody for WB - ABIN151832 : Silva, Pereira, Morgado, Kong, Martins, Faustino, Liebhaber, Romão: The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context. in RNA (New York, N.Y.) 2006 (PubMed)
    Show all 9 Pubmed References

  2. Human Polyclonal UPF1 Primary Antibody for WB - ABIN1882125 : Mendell, ap Rhys, Dietz: Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. in Science (New York, N.Y.) 2002 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal UPF1 Primary Antibody for IP, PLA - ABIN438392 : Martins, Proença, Silva, Barbosa, Silva, Faustino, Romão: Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal UPF1 Primary Antibody for WB - ABIN388607 : Ohnishi, Yamashita, Kashima, Schell, Anders, Grimson, Hachiya, Hentze, Anderson, Ohno: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. in Molecular cell 2003 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal UPF1 Primary Antibody for WB - ABIN151833 : Silva, Ribeiro, Inácio, Liebhaber, Romão: Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. in RNA (New York, N.Y.) 2008 (PubMed)

  6. Human Polyclonal UPF1 Primary Antibody for PLA, WB - ABIN151834 : Luke, Azzalin, Hug, Deplazes, Peter, Lingner: Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. in Nucleic acids research 2008 (PubMed)

More Antibodies against UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Interaction Partners

Caenorhabditis elegans (C. elegans) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. results suggest that the role of SMG-5 (show ZCCHC11 Antibodies) is to direct protein phosphatase 2A to its SMG-2 substrate

  2. SMG-2 interacts with SMG-3 (show UPF2 Antibodies), SMG-3 (show UPF2 Antibodies) interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3 (show UPF2 Antibodies). SMG-2 preferentially associates with PTC (show PTCH1 Antibodies)-containing mRNAs.

Human UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.

  2. MARVELD1 (show MARVELD1 Antibodies) substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (show RBM8A Antibodies). MARVELD1 (show MARVELD1 Antibodies) promotes the dissociation of SMG1 (show SMG1 Antibodies) from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (show SMG5 Antibodies).

  3. UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.

  4. Upregulation of SNHG6 regulates ZEB1 (show ZEB1 Antibodies) expression by competitively binding miR (show MLXIP Antibodies)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.

  5. Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.

  6. CARM1 (show CARM1 Antibodies) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.

  7. Upf1 is a RNA helicase (show DDX46 Antibodies) essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.

  8. Results present evidence for a critical role for Upf1 ATPase (show DNAH8 Antibodies) activity in nonsense-mediated decay target discrimination, with preferential ATPase (show DNAH8 Antibodies)-dependent release of Upf1 from non-target mRNAs as part of the underlying mechanism.

  9. GR and PNRC2 (show PNRC2 Antibodies) interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation

  10. Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5 (show SMG5 Antibodies), and Smg7 led to increased levels of viral proteins and and virus release.

Mouse (Murine) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .

  2. results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome

UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Antigen Profile

Protein Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

Gene names and symbols associated with UPF1

  • regulator of nonsense transcripts 1 (Rent1) antibody
  • UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) antibody
  • regulator of nonsense transcripts 1 (Tc00.1047053511317.30) antibody
  • regulator of nonsense transcripts 1 (Tb927.5.2140) antibody
  • regulator of nonsense transcripts 1 (TVAG_453890) antibody
  • regulator of nonsense transcripts 1 (TVAG_237840) antibody
  • regulator of nonsense transcripts 1 (AOR_1_1018194) antibody
  • regulator of nonsense transcripts 1 (HPB8_739) antibody
  • Protein SMG-2 (smg-2) antibody
  • upf1 regulator of nonsense transcripts homolog (yeast) (upf1) antibody
  • UPF1 regulator of nonsense transcripts homolog (yeast) (Upf1) antibody
  • AO090012000584 antibody
  • B430202H16Rik antibody
  • HUPF1 antibody
  • NORF1 antibody
  • PNORF-1 antibody
  • pNORF1 antibody
  • Rent1 antibody
  • smg-2 antibody
  • Tb05.3C6.50 antibody
  • Upflp antibody
  • wu:fi40f07 antibody
  • wu:fj48a01 antibody
  • zgc:55472 antibody

Protein level used designations for UPF1

regulator of nonsense transcripts 1 , ATP-dependent helicase RENT1 , UP Frameshift 1 , delta helicase , nonsense mRNA reducing factor 1 , smg-2 homolog, nonsense mediated mRNA decay factor , up-frameshift mutation 1 homolog , up-frameshift suppressor 1 homolog , yeast Upf1p homolog , Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) , mUpf1

GENE ID SPECIES
306350 Rattus norvegicus
456373 Pan troglodytes
3541249 Trypanosoma cruzi strain CL Brener
3657316 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4775578 Trichomonas vaginalis G3
5467310 Trichomonas vaginalis G3
5988051 Aspergillus oryzae RIB40
9349309 Helicobacter pylori B8
171696 Caenorhabditis elegans
406783 Danio rerio
5976 Homo sapiens
19704 Mus musculus
420119 Gallus gallus
476664 Canis lupus familiaris
532933 Bos taurus
684558 Rattus norvegicus
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