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UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Proteins (4) and many more products for this protein.
Showing 10 out of 64 products:
Human Polyclonal UPF1 Primary Antibody for WB - ABIN151832
Silva, Pereira, Morgado, Kong, Martins, Faustino, Liebhaber, Romão: The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context. in RNA (New York, N.Y.) 2006
Show all 9 Pubmed References
Human Polyclonal UPF1 Primary Antibody for WB - ABIN1882125
Mendell, ap Rhys, Dietz: Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. in Science (New York, N.Y.) 2002
Show all 6 Pubmed References
Human Polyclonal UPF1 Primary Antibody for IP, PLA - ABIN438392
Martins, Proença, Silva, Barbosa, Silva, Faustino, Romão: Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels. in PLoS ONE 2012
Show all 2 Pubmed References
Human Polyclonal UPF1 Primary Antibody for WB - ABIN388607
Ohnishi, Yamashita, Kashima, Schell, Anders, Grimson, Hachiya, Hentze, Anderson, Ohno: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. in Molecular cell 2003
Show all 3 Pubmed References
Human Polyclonal UPF1 Primary Antibody for WB - ABIN151833
Silva, Ribeiro, Inácio, Liebhaber, Romão: Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. in RNA (New York, N.Y.) 2008
Human Polyclonal UPF1 Primary Antibody for PLA, WB - ABIN151834
Luke, Azzalin, Hug, Deplazes, Peter, Lingner: Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. in Nucleic acids research 2008
results suggest that the role of SMG-5 (show ZCCHC11 Antibodies) is to direct protein phosphatase 2A to its SMG-2 substrate
SMG-2 interacts with SMG-3 (show UPF2 Antibodies), SMG-3 (show UPF2 Antibodies) interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3 (show UPF2 Antibodies). SMG-2 preferentially associates with PTC (show PTCH1 Antibodies)-containing mRNAs.
The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.
MARVELD1 (show MARVELD1 Antibodies) substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (show RBM8A Antibodies). MARVELD1 (show MARVELD1 Antibodies) promotes the dissociation of SMG1 (show SMG1 Antibodies) from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (show SMG5 Antibodies).
UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.
Upregulation of SNHG6 regulates ZEB1 (show ZEB1 Antibodies) expression by competitively binding miR (show MLXIP Antibodies)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.
Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.
CARM1 (show CARM1 Antibodies) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.
Upf1 is a RNA helicase (show DDX46 Antibodies) essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.
Results present evidence for a critical role for Upf1 ATPase (show DNAH8 Antibodies) activity in nonsense-mediated decay target discrimination, with preferential ATPase (show DNAH8 Antibodies)-dependent release of Upf1 from non-target mRNAs as part of the underlying mechanism.
GR and PNRC2 (show PNRC2 Antibodies) interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation
Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5 (show SMG5 Antibodies), and Smg7 led to increased levels of viral proteins and and virus release.
Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .
results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
regulator of nonsense transcripts 1
, ATP-dependent helicase RENT1
, UP Frameshift 1
, delta helicase
, nonsense mRNA reducing factor 1
, smg-2 homolog, nonsense mediated mRNA decay factor
, up-frameshift mutation 1 homolog
, up-frameshift suppressor 1 homolog
, yeast Upf1p homolog
, Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)