UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Proteins (UPF1)

UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UPF1 5976 Q92900
UPF1 19704 Q9EPU0
Rat UPF1 UPF1 684558  
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
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UPF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Interaction Partners

Caenorhabditis elegans (C. elegans) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. results suggest that the role of SMG-5 (show ZCCHC11 Proteins) is to direct protein phosphatase 2A to its SMG-2 substrate

  2. SMG-2 interacts with SMG-3, SMG-3 interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3. SMG-2 preferentially associates with PTC (show PTCH1 Proteins)-containing mRNAs.

Human UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.

  2. MARVELD1 (show MARVELD1 Proteins) substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (show RBM8A Proteins). MARVELD1 (show MARVELD1 Proteins) promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (show SMG5 Proteins).

  3. UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.

  4. Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR (show MLXIP Proteins)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.

  5. Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.

  6. CARM1 (show CARM1 Proteins) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.

  7. Upf1 is a RNA helicase essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.

  8. Results present evidence for a critical role for Upf1 ATPase activity in nonsense-mediated decay target discrimination, with preferential ATPase-dependent release of Upf1 from non-target mRNAs as part of the underlying mechanism.

  9. GR and PNRC2 (show PNRC2 Proteins) interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation

  10. Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5 (show SMG5 Proteins), and Smg7 led to increased levels of viral proteins and and virus release.

Mouse (Murine) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) interaction partners

  1. Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .

  2. results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome

UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Protein Profile

Protein Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

Gene names and symbols associated with UPF1

  • UPF1, RNA helicase and ATPase (UPF1)
  • UPF1 regulator of nonsense transcripts homolog (yeast) (Upf1)
  • upf1 regulator of nonsense transcripts homolog (yeast) (upf1)
  • regulator of nonsense transcripts 1 (Tc00.1047053511317.30)
  • regulator of nonsense transcripts 1 (Tb927.5.2140)
  • regulator of nonsense transcripts 1 (TVAG_453890)
  • regulator of nonsense transcripts 1 (TVAG_237840)
  • regulator of nonsense transcripts 1 (AOR_1_1018194)
  • regulator of nonsense transcripts 1 (HPB8_739)
  • Regulator of nonsense transcripts 1 (smg-2)
  • UPF1, RNA helicase and ATPase (Upf1)
  • UPF1 regulator of nonsense transcripts homolog S homeolog (upf1.S)
  • AO090012000584 protein
  • B430202H16Rik protein
  • hupf1 protein
  • norf1 protein
  • PNORF-1 protein
  • pnorf1 protein
  • rent1 protein
  • smg-2 protein
  • Tb05.3C6.50 protein
  • upf1 protein
  • Upflp protein
  • wu:fi40f07 protein
  • wu:fj48a01 protein
  • zgc:55472 protein

Protein level used designations for UPF1

ATP-dependent helicase RENT1 , UP Frameshift 1 , delta helicase , nonsense mRNA reducing factor 1 , regulator of nonsense transcripts 1 , smg-2 homolog, nonsense mediated mRNA decay factor , up-frameshift mutation 1 homolog , up-frameshift suppressor 1 homolog , yeast Upf1p homolog , Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) , mUpf1 , LOW QUALITY PROTEIN: regulator of nonsense transcripts 1 , UPF1 regulator of nonsense transcripts homolog S homeolog

GENE ID SPECIES
5976 Homo sapiens
19704 Mus musculus
406783 Danio rerio
420119 Gallus gallus
456373 Pan troglodytes
3541249 Trypanosoma cruzi strain CL Brener
3657316 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4775578 Trichomonas vaginalis G3
5467310 Trichomonas vaginalis G3
5988051 Aspergillus oryzae RIB40
9349309 Helicobacter pylori B8
171696 Caenorhabditis elegans
476664 Canis lupus familiaris
532933 Bos taurus
684558 Rattus norvegicus
100713813 Cavia porcellus
444289 Xenopus laevis
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