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anti-UPF3 Regulator of Nonsense Transcripts Homolog B (Yeast) (UPF3B) Antibodies

UPF3B encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF3B Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UPF3B 65109 Q9BZI7
UPF3B 68134  
UPF3B 313449  
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Top anti-UPF3B Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-UPF3B Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- UPF3B/RENT3B Picoband antibody, IHC(P) IHC(P): Rat Testis Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC, WB UPF3B antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain EpitheliaI cells of fundic gland (arrows) in Human Stomach. Magnification is at 400X UPF3B antibody used at 1.25 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details
Human Rabbit Un-conjugated WB UPF3B antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 8 to 10 Days
$595.83
Details

UPF3B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human


Mouse (Murine)


Rat (Rattus)


Top referenced anti-UPF3B Antibodies

  1. Human Polyclonal UPF3B Primary Antibody for WB - ABIN2776615 : Chamieh, Ballut, Bonneau, Le Hir: NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. in Nature structural & molecular biology 2008 (PubMed)

  2. Cow (Bovine) Polyclonal UPF3B Primary Antibody for IHC, WB - ABIN2776563 : Lehner, Sanderson: A protein interaction framework for human mRNA degradation. in Genome research 2004 (PubMed)

More Antibodies against UPF3B Interaction Partners

Human UPF3 Regulator of Nonsense Transcripts Homolog B (Yeast) (UPF3B) interaction partners

  1. UPF3B gene mutation is associated with Lujan-Fryns syndrome.

  2. the neurodevelopmental phenotype of UPF3B missense mutation is caused by impairment of nonsense-mediated mRNA decay pathway function altering neuronal differentiation.

  3. These findings indicate that SATB2 (show SATB2 Antibodies) activates UPF3B expression through binding to its promoter.

  4. Data indicate the mutation p.R430X of UPF3B gene as the genetic etiology in the mental retardation pedigree.

  5. results demonstrate that the UPF3B-dependent NMD pathway is a major regulator of the transcriptome and that its targets have important roles in neuronal cells.

  6. The two cases with renal dysplasia and developmental delay showed remarkable clinical variability despite having the same mutation in UPF3B.

  7. Our results demonstrate that in addition to Lujan-Fryns and FG syndromes, UPF3B protein truncation mutations can cause also nonspecific XLMR (show DLG3 Antibodies).

  8. 3.4 A resolution crystal structure of a minimal UPF3b-EJC assembly, consisting of the interacting domains of five proteins (UPF3b, MAGO (show MAGOHB Antibodies), Y14 (show RBM8A Antibodies), eIF4AIII (show EIF4A3 Antibodies), and Barentsz (show CASC3 Antibodies)) together with RNA and adenylyl-imidodiphosphate

  9. A conserved domain of hUpf3b mediates an interaction with the EJC protein Y14 (show RBM8A Antibodies). Y14 (show RBM8A Antibodies) is required for nonsense-mediated decay induced by tethered hUpf3b.

  10. The protein region that mediates this interaction and discriminates between hUpf3a (show UPF3A Antibodies) and hUpf3b in NMD function is located in the C-terminal domain and fully contained within a small sequence that is highly conserved in Upf3b but not Upf3a (show UPF3A Antibodies) proteins

Mouse (Murine) UPF3 Regulator of Nonsense Transcripts Homolog B (Yeast) (UPF3B) interaction partners

  1. Analysis revealed that UPF3A (show UPF3A Antibodies) is a broadly acting nonsense-mediated RNA decay inhibitor. This discovery implies that UPF3A (show UPF3A Antibodies) and UPF3B do not primarily work in a complementary or redundant manner as previously supposed; instead, they oppose each other, allowing this paralog pair to serve as a molecular rheostat to modulate the level of gene expression during development.

  2. Evidence suggests Upf3b-dependent nonsense-mediated mRNA decay is regulated at multiple levels during development including regulation of expression and sub-cellular localization of Upf3b.

UPF3B Antigen Profile

Protein Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with UPF3B

  • UPF3 regulator of nonsense transcripts homolog B (yeast) (UPF3B) antibody
  • UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b) antibody
  • 5730594O13Rik antibody
  • AI317193 antibody
  • AW541158 antibody
  • HUPF3B antibody
  • MRXS14 antibody
  • RENT3B antibody
  • RGD1560264 antibody
  • UPF3X antibody

Protein level used designations for UPF3B

hUpf3p-X , nonsense mRNA reducing factor 3B , regulator of nonsense transcripts 3B , up-frameshift suppressor 3 homolog B , up-frameshift suppressor 3 homolog on chromosome X , hUPF3B

GENE ID SPECIES
65109 Homo sapiens
481031 Canis lupus familiaris
616181 Bos taurus
68134 Mus musculus
313449 Rattus norvegicus
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