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Ubiquilin 1 Proteins (UBQLN1)

UBQLN1 encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 1 Antibodies (87) and Ubiquilin 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBQLN1 29979 Q9UMX0
Mouse UBQLN1 UBQLN1 56085 Q8R317
UBQLN1 114590 Q9JJP9
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Top Ubiquilin 1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,670.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UBQLN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

More Proteins for Ubiquilin 1 (UBQLN1) Interaction Partners

Human Ubiquilin 1 (UBQLN1) interaction partners

  1. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 (show BACE Proteins) and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

  2. The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer.

  3. Chloroquine derivative D5 downregulates presenilin expression via the inhibition of ubiquilin 1 expression.

  4. found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1

  5. High UBQLN1 expression is associated with low radiosensitivity in breast cancer.

  6. Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease

  7. Human ubiquilin-1 overexpression in transgenic mice increases the lifespan and delays accumulation of Huntingtin (show HTT Proteins) aggregates in the R6/2 mouse model of Huntington's disease.

  8. The results demonstrate that in Alzheimer's disease hippocampus, ubiquilin-1 immunoreactivity increases in the neuronal nucleoplasm and is associated with region-specific neurofibrillary changes.

  9. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT Proteins) inclusions

  10. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 (show UBQLN4 Proteins) UBL domain and the Ubqln1 UBA domain.

Mouse (Murine) Ubiquilin 1 (UBQLN1) interaction partners

  1. Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 (show BACE Proteins) and thereby APP (show APP Proteins) processing and Abeta (show APP Proteins) accumulation

  2. propose a model in which UBQLN1 recognizes Mycobacterium tuberculosis and in turn recruits the autophagy machinery thereby promoting intracellular control of Mycobacterium tuberculosis

  3. results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT Proteins) inclusions

  4. Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis.

  5. UBQLN1-transfected cells did not show increased starvation-induced cell death

  6. Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2 (show PSEN2 Proteins)) protein levels in cells.

Ubiquilin 1 (UBQLN1) Protein Profile

Protein Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Ubiquilin 1 Proteins (UBQLN1)

  • ubiquilin 1 (UBQLN1)
  • ubiquilin 1 (Ubqln1)
  • 1110046H03Rik protein
  • 1810030E05Rik protein
  • AU019746 protein
  • C77538 protein
  • D13Ertd372e protein
  • Da41 protein
  • Dsk2 protein
  • Plic-1 protein
  • Plic1 protein
  • UBQLN1 protein
  • UBQN protein
  • Xdrp1 protein

Protein level used designations for Ubiquilin 1 Proteins (UBQLN1)

ubiquilin-1 , ubiquilin 1 , ubiquilin-1-like , hPLIC-1 , protein linking IAP with cytoskeleton 1 , PLIC-1

GENE ID SPECIES
100174657 Pongo abelii
100302096 Ovis aries
100394790 Callithrix jacchus
29979 Homo sapiens
282392 Bos taurus
56085 Mus musculus
114590 Rattus norvegicus
427454 Gallus gallus
476312 Canis lupus familiaris
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