Ubiquilin 2 (UBQLN2) ELISA Kits

UBQLN2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 2 Antibodies (53) and Ubiquilin 2 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
UBQLN2 29978 Q9UHD9
UBQLN2 54609 Q9QZM0
Anti-Rat UBQLN2 UBQLN2 317396  
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Top Ubiquilin 2 ELISA Kits at antibodies-online.com

Showing 2 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.64 ng/mL 1.56-100 ng/mL 96 Tests Log in to see 13 to 16 Days
$589.47
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for Ubiquilin 2 Interaction Partners

Human Ubiquilin 2 (UBQLN2) interaction partners

  1. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

  2. We analyzed mutations in the UBQLN2 gene in a Chinese cohort with sporadic ALS (sALS). A novel missense mutation was detected in one sALS patient. The p.M392V mutation substitutes a highly conserved residue, has not been reported in the population databases, and previously, at the same residue, a missense mutation p.M392I was detected in two Turkey ALS patients and was considered to be pathogenic.

  3. Frontotemporal dementia -linked mutations in gene ubiquilin 2 encoding autophagy adaptor proteins , indicate that impaired autophagy might cause Frontotemporal dementia.

  4. excess UBQLN2 is toxic rather than protective to neurons and that uncontrolled enhancement of UBQLN2 function is involved in UBQLN2 pathogenesis

  5. Ubiquilin-2 immunostaining - a new marker as a diagnostic supplement in urine cytology?

  6. UBQLN2 is specifically expressed in the urine of urothelial carcinoma patients.

  7. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia (show USP14 ELISA Kits) type 3

  8. These findings provide a molecular basis for the development of ALS/FTD-associated proteinopathy and establish novel therapeutic targets for ALS.

  9. Mutations in UBQLN2 gene cause dominant inheritance of amyotrophic lateral sclerosis due to Defective Proteasome Delivery.

  10. UBQLN2 may be a new molecular target for chemotherapeutics and a useful clinicopathological marker in human osteosarcoma.

Mouse (Murine) Ubiquilin 2 (UBQLN2) interaction partners

  1. UBQLN2 most evidently bound to HSP70 (show HSP70 ELISA Kits)-type chaperones, UBQLN1 (show UBQLN1 ELISA Kits) and UBQLN4 and to a lesser extent to proteasomal subunits; UBQLN2 may be involved in the regulation of misfolded proteins. Mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice.

  2. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia (show USP14 ELISA Kits) type 3

  3. UBQLN2 dysregulation in neurons can drive NF-kappaB (show NFKB1 ELISA Kits) activation and cytosolic TDP-43 (show TARDBP ELISA Kits) aggregation.

  4. Transduction of UBQLN2 mutants (P497H, P497S, and P506T) induce proteinopathy and cause behavioral deficits, supporting a "toxic" gain-of-function amyotrophic lateral sclerosis model, in mice.

  5. results were confirmed by similar findings for ubiquilin-1 (show UBQLN1 ELISA Kits) and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT ELISA Kits) inclusions

  6. UBQLN2-transfected cells did not show increased starvation-induced cell death.

Ubiquilin 2 (UBQLN2) Antigen Profile

Antigen Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases\; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Gene names and symbols associated with Ubiquilin 2 (UBQLN2) ELISA Kits

  • ubiquilin 1 (ubqln1) antibody
  • ubiquilin 2 (UBQLN2) antibody
  • ubiquilin 2 (LOC100347089) antibody
  • ubiquilin 2 (Ubqln2) antibody
  • ALS15 antibody
  • Chap1 antibody
  • da41 antibody
  • Dsk2 antibody
  • HRIHFB2157 antibody
  • N4BP4 antibody
  • plic-1 antibody
  • Plic-2 antibody
  • Plic2 antibody
  • RGD1563566 antibody
  • UBQLN2 antibody
  • ubqn antibody
  • xdrp1 antibody

Protein level used designations for Ubiquilin 2 (UBQLN2) ELISA Kits

ubiquilin 2 , ubiquilin-2 , Nedd4 binding protein 4 , protein linking IAP with cytoskeleton 2 , ubiquitin-like product Chap1/Dsk2 , Ubiquitin-related protein

GENE ID SPECIES
394829 Xenopus (Silurana) tropicalis
419078 Gallus gallus
446997 Xenopus laevis
491909 Canis lupus familiaris
539529 Bos taurus
743819 Pan troglodytes
100347089 Oryctolagus cuniculus
29978 Homo sapiens
54609 Mus musculus
317396 Rattus norvegicus
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