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Plays a role in the regulation of proteasomal protein degradation. Additionally we are shipping UBQLN4 Proteins (2) and many more products for this protein.
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UBQLN4, APP (show APP Antibodies), CTNNB1 (show CTNNB1 Antibodies), SHBG (show SHBG Antibodies), and COL1A1 (show COL1A1 Antibodies) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition
UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle.
results suggested that CIP75 is essential for the interaction of Cx43 (show GJA1 Antibodies) and the proteasome, but that alternate compensatory mechanisms exist to supplement the degradation normally facilitated by CIP75
Targeting of Ubqln1 (show UBQLN1 Antibodies) to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 (show UBQLN1 Antibodies) UBA domain.
although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 (show GJA1 Antibodies) and stimulation of Cx43 (show GJA1 Antibodies) proteasomal degradation does not require the ubiquitination of Cx43 (show GJA1 Antibodies).
Co-immunoprecipitation confirmed the binding of small hydrophobic (SH) protein of mumps virus and ubiquilin 4 and demonstrates that a truncated protein fragment corresponding to amino acids 136-270 of ubiquilin 4 was sufficient for interaction.
A novel connexin43 (show GJA1 Antibodies)-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43 (show GJA1 Antibodies)
Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation.
, ubiquilin 4
, ataxin-1 ubiquitin-like interacting protein
, ataxin-1 interacting ubiquitin-like protein
, ataxin-1 ubiquitin-like-interacting protein A1U
, connexin43-interacting protein of 75 kDa