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The protein encoded by UCHL1 belongs to the peptidase C12 family. Additionally we are shipping UCHL1 Proteins (40) and UCHL1 Kits (20) and many more products for this protein.
Showing 10 out of 341 products:
Human Polyclonal UCHL1 Primary Antibody for FACS, IF - ABIN1882188
Doran, Jackson, Kynoch, Thompson: Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. in Journal of neurochemistry 1983
Show all 8 references for ABIN1882188
Human Polyclonal UCHL1 Primary Antibody for EIA, WB - ABIN453450
Maraganore, de Andrade, Lesnick, Farrer, Bower, Hardy, Rocca: Complex interactions in Parkinson's disease: a two-phased approach. in Movement disorders : official journal of the Movement Disorder Society 2003
Show all 5 references for ABIN453450
Human Polyclonal UCHL1 Primary Antibody for EIA, IHC (p) - ABIN357509
Nishikawa, Li, Kawamura, Osaka, Wang, Hara, Hirokawa, Manago, Amano, Noda, Aoki, Wada: Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants. in Biochemical and biophysical research communications 2003
Show all 5 references for ABIN357509
Human Monoclonal UCHL1 Primary Antibody for WB - ABIN1882287
Boudreaux, Maiti, Davies, Das: Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 4 references for ABIN1882287
Human Polyclonal UCHL1 Primary Antibody for FACS, IF - ABIN388868
Caballero, Resto, Patturajan, Meerzaman, Guo, Engles, Yochem, Ratovitski, Sidransky, Jen: Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). in Oncogene 2002
Show all 2 references for ABIN388868
Human Polyclonal UCHL1 Primary Antibody for IF, IHC (p) - ABIN388870
Saigoh, Wang, Suh, Yamanishi, Sakai, Kiyosawa, Harada, Ichihara, Wakana, Kikuchi, Wada: Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. in Nature genetics 1999
Show all 2 references for ABIN388870
Human Monoclonal UCHL1 Primary Antibody for IHC (p) - ABIN180669
Wilkinson, Lee, Deshpande, Duerksen-Hughes, Boss, Pohl: The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. in Science (New York, N.Y.) 1989
Show all 2 references for ABIN180669
Cow (Bovine) Polyclonal UCHL1 Primary Antibody for EIA, WB - ABIN499139
Wu, Chen, Chen, Chao, Ro, Fung, Hsiao, Hu, Lee-Chen: Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese. in Clinica chimica acta; international journal of clinical chemistry 2010
The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (show RAB1A Antibodies)-induced transformation of, germinal center B cells.
Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (show SMN1 Antibodies). Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA (show SMN1 Antibodies).
Parkin (show PARK2 Antibodies) mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13 (show UBE2N Antibodies)/Uev1a E2 ubiquitin-conjugating enzyme (show UBE2L6 Antibodies) complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway.
defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM
UCH-L1 facilitates PDGF (show PDGFA Antibodies)-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts
UCHL1 upregulation in ACTN4 (show ACTN4 Antibodies)-associated FSGS (show ACTN4 Antibodies).
downregulated miR (show MLXIP Antibodies)-181b induces neuroprotection against ischemic injury through negatively regulating HSPA5 (show HSPA5 Antibodies) and UCHL1 protein levels
The proteases HtrA2/Omi (show HTRA2 Antibodies) and UCH-L1 regulate TNF (show TNF Antibodies)-induced necroptosis.
Activation of the NF-kappaB (show NFKB1 Antibodies) signaling pathway could be the major pathogenic mechanism to up-regulate UCH-L1 in podocyte injury.
in AD, Abeta (show APP Antibodies) may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF (show BDNF Antibodies)/TrkB (show NTRK2 Antibodies)-mediated retrograde signaling, compromising synaptic plasticity and neuronal survival.
High UCHL1 expression is associated with multiple myeloma.
The promoter methylation degree of FLNC (show FLNC Antibodies), THBS1 (show THBS1 Antibodies), UCHL1, and DLEC1 (show DLEC1 Antibodies) in serum could tell the existence of GC and only UCHL1 in the serum was also associated with poor prognosis of GC.
The results of this study suggest the role for UCHL1 in promoting Corticospinal motor neurons health and stability.
UCH-L1 is significantly associated with outcome, but it does not add predictive power to commonly used prognostic variables in a population of patients with TBI of varying severities.
Serum UCH-l1 levels serve as a novel biomarker for neuronal damage from white matter lesions.
High Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4 (show NOX4 Antibodies).
These findings demonstrated that UCHL1 promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity by activating Akt (show AKT1 Antibodies) and Erk1/2 (show MAPK1/3 Antibodies) pathways
These results suggest that ubiquitin C-terminal hydrolase and alphaII-spectrin breakdown product 145 kDa may be useful in assessing outcome after pediatric traumatic brain injury.
Pathogenetic tau truncation may contribute to synaptic deterioration in Alzheimer disease by aberrant recruitment of Parkin (show PARK2 Antibodies) and UCHL-1 to mitochondria.
These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of cortical granules.
The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA.
Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM.
There was no difference in enteric neuronal density and distribution in the groups of animals with intestinal disease compared with those without, apart from two (out of 28) horses with intestinal disease that showed reduction in PGP 9.5 immunoreactivity.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
ubiquitin carboxyl-terminal hydrolase isozyme L1
, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
, ubiquitin carboxyl-terminal esterase L1
, gracile axonal dystrophy
, neuron cytoplasmic protein 9.5
, protein gene product 9.5
, ubiquitin thioesterase L1
, ubiquitin C-terminal hydrolase
, PGP 9.5
, ubiquitin carboxy-terminal hydrolase L1
, ubiquitin C-terminal hydrolase-L1
, ubiquitin carboxyl-terminal hydrolase L1
, ubiquitin thiolesterase L1