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anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Antibodies

The protein encoded by UCHL1 belongs to the peptidase C12 family. Additionally we are shipping UCHL1 Proteins (40) and UCHL1 Kits (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UCHL1 22223 Q9R0P9
UCHL1 7345 P09936
UCHL1 29545 Q00981
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Top anti-UCHL1 Antibodies at antibodies-online.com

Showing 10 out of 341 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p) 0.5 mL Log in to see 10 to 12 Days
$496.65
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Goat Un-conjugated EIA, WB AP21291PU-N UCHL1 antibody staining of Human Hippocampus lysate at 0.01 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. AP21291PU-N UCHL1 antibody staining of Mouse (A) and Rat (B) Brain lysates at 0.01 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Cow Goat Un-conjugated EIA, WB AP21292PU-N UCHL1 antibody staining of Mouse (A) and Rat (B) Brain lysate at 0.01 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of UCHL1-V31 (ABIN388868) in CEM, Jurkat, Y79 cell line and mouse brain tissue lysates (35 µg/lane). UCHL1 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of UCHL1 (arrow) using rabbit polyclonal UCHL1-V31 (ABIN388868). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the UCHL1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of UCHL1 Antibody (C-term) (ABIN388870) in Ramos, NCI-H460 cell line and mouse brain tissue lysates (35 µg/lane). UCHL1 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of UCHL1 (arrow) using rabbit polyclonal UCHL1 Antibody (C-term) (ABIN388870). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the UCHL1 gene (Lane 2) . 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of UCHL1 Antibody (C-term) in Ramos, NCI-H460 cell line and mouse brain tissue lysates (35ug/lane). UCHL1 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of UCHL1 (arrow) using rabbit polyclonal UCHL1 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the UCHL1 gene (Lane 2) . 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated WB UCHL1 Antibody (C-term) (ABIN1882287) western blot analysis in 293T,NCI-H1299,rat PC-12 cell line lysates (35 µg/lane). This demonstrates the UCHL1 antibody detected the UCHL1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB UCHL1 Antibody (C-term) (ABIN1882188) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. UCHL1 Antibody (C-term) (ABIN1882188) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

UCHL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-UCHL1 Antibodies

  1. Human Polyclonal UCHL1 Primary Antibody for FACS, IF - ABIN1882188 : Doran, Jackson, Kynoch, Thompson: Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. in Journal of neurochemistry 1983 (PubMed)
    Show all 8 references for ABIN1882188

  2. Human Polyclonal UCHL1 Primary Antibody for EIA, WB - ABIN453450 : Maraganore, de Andrade, Lesnick, Farrer, Bower, Hardy, Rocca: Complex interactions in Parkinson's disease: a two-phased approach. in Movement disorders : official journal of the Movement Disorder Society 2003 (PubMed)
    Show all 5 references for ABIN453450

  3. Human Polyclonal UCHL1 Primary Antibody for EIA, IHC (p) - ABIN357509 : Nishikawa, Li, Kawamura, Osaka, Wang, Hara, Hirokawa, Manago, Amano, Noda, Aoki, Wada: Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 references for ABIN357509

  4. Human Monoclonal UCHL1 Primary Antibody for WB - ABIN1882287 : Boudreaux, Maiti, Davies, Das: Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 4 references for ABIN1882287

  5. Human Polyclonal UCHL1 Primary Antibody for FACS, IF - ABIN388868 : Caballero, Resto, Patturajan, Meerzaman, Guo, Engles, Yochem, Ratovitski, Sidransky, Jen: Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). in Oncogene 2002 (PubMed)
    Show all 2 references for ABIN388868

  6. Human Polyclonal UCHL1 Primary Antibody for IF, IHC (p) - ABIN388870 : Saigoh, Wang, Suh, Yamanishi, Sakai, Kiyosawa, Harada, Ichihara, Wakana, Kikuchi, Wada: Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. in Nature genetics 1999 (PubMed)
    Show all 2 references for ABIN388870

  7. Human Monoclonal UCHL1 Primary Antibody for IHC (p) - ABIN180669 : Wilkinson, Lee, Deshpande, Duerksen-Hughes, Boss, Pohl: The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. in Science (New York, N.Y.) 1989 (PubMed)
    Show all 2 references for ABIN180669

  8. Cow (Bovine) Polyclonal UCHL1 Primary Antibody for EIA, WB - ABIN499139 : Wu, Chen, Chen, Chao, Ro, Fung, Hsiao, Hu, Lee-Chen: Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese. in Clinica chimica acta; international journal of clinical chemistry 2010 (PubMed)

More Antibodies against UCHL1 Interaction Partners

Mouse (Murine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (show RAB1A Antibodies)-induced transformation of, germinal center B cells.

  2. Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (show SMN1 Antibodies). Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA (show SMN1 Antibodies).

  3. Parkin (show PARK2 Antibodies) mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13 (show UBE2N Antibodies)/Uev1a E2 ubiquitin-conjugating enzyme (show UBE2L6 Antibodies) complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway.

  4. defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM

  5. UCH-L1 facilitates PDGF (show PDGFA Antibodies)-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts

  6. UCHL1 upregulation in ACTN4 (show ACTN4 Antibodies)-associated FSGS (show ACTN4 Antibodies).

  7. downregulated miR (show MLXIP Antibodies)-181b induces neuroprotection against ischemic injury through negatively regulating HSPA5 (show HSPA5 Antibodies) and UCHL1 protein levels

  8. The proteases HtrA2/Omi (show HTRA2 Antibodies) and UCH-L1 regulate TNF (show TNF Antibodies)-induced necroptosis.

  9. Activation of the NF-kappaB (show NFKB1 Antibodies) signaling pathway could be the major pathogenic mechanism to up-regulate UCH-L1 in podocyte injury.

  10. in AD, Abeta (show APP Antibodies) may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF (show BDNF Antibodies)/TrkB (show NTRK2 Antibodies)-mediated retrograde signaling, compromising synaptic plasticity and neuronal survival.

Human Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. Folloing aneurysmal subarachnoid hemorrhage, eleevated UCH-L1 levels during the five-day follow-up were associated with unfavorable neurological outcome.

  2. UCH-L1 plays a crucial role in modulating the degradation of EGFR (show EGFR Antibodies) and promoting malignant properties in multi-drug resistant breast cancer

  3. High UCHL1 expression is associated with multiple myeloma.

  4. The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (show RAB1A Antibodies)-induced transformation of, germinal center B cells.

  5. The promoter methylation degree of FLNC (show FLNC Antibodies), THBS1 (show THBS1 Antibodies), UCHL1, and DLEC1 (show DLEC1 Antibodies) in serum could tell the existence of GC and only UCHL1 in the serum was also associated with poor prognosis of GC.

  6. The results of this study suggest the role for UCHL1 in promoting Corticospinal motor neurons health and stability.

  7. UCH-L1 is significantly associated with outcome, but it does not add predictive power to commonly used prognostic variables in a population of patients with TBI of varying severities.

  8. Serum UCH-l1 levels serve as a novel biomarker for neuronal damage from white matter lesions.

  9. High Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4 (show NOX4 Antibodies).

  10. These findings demonstrated that UCHL1 promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity by activating Akt (show AKT1 Antibodies) and Erk1/2 (show MAPK1/3 Antibodies) pathways

Cow (Bovine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of cortical granules.

Pig (Porcine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA.

  2. Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM.

Horse (Equine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. There was no difference in enteric neuronal density and distribution in the groups of animals with intestinal disease compared with those without, apart from two (out of 28) horses with intestinal disease that showed reduction in PGP 9.5 immunoreactivity.

UCHL1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.

Gene names and symbols associated with UCHL1

  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (uchl1) antibody
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1) antibody
  • Ubiquitin carboxyl-terminal hydrolase isozyme L1 (uchl1) antibody
  • ubiquitin carboxyl-terminal esterase L1 (LOC100304750) antibody
  • ubiquitin carboxyl-terminal esterase L1 (LOC100348287) antibody
  • ubiquitin carboxyl-terminal esterase L1 (LOC100357806) antibody
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1) antibody
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (Uchl1) antibody
  • AW822034 antibody
  • C88048 antibody
  • cb358 antibody
  • gad antibody
  • MGC132191 antibody
  • PARK5 antibody
  • PGP9.5 antibody
  • PGP 9.5 antibody
  • PGP95 antibody
  • R75593 antibody
  • Uch-L1 antibody
  • UCHL-1 antibody
  • uchl1 antibody
  • wu:fc55h08 antibody

Protein level used designations for UCHL1

ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) , ubiquitin carboxyl-terminal esterase L1 , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin thioesterase L1 , ubiquitin C-terminal hydrolase , PGP 9.5 , PGP9.5 , UCH-L1 , ubiquitin carboxy-terminal hydrolase L1 , ubiquitin C-terminal hydrolase-L1 , ubiquitin carboxyl-terminal hydrolase L1 , ubiquitin thiolesterase L1

GENE ID SPECIES
325119 Danio rerio
461185 Pan troglodytes
479098 Canis lupus familiaris
751589 Taeniopygia guttata
770302 Gallus gallus
496780 Xenopus (Silurana) tropicalis
735204 Xenopus laevis
100196868 Salmo salar
100304750 Ictalurus punctatus
100348287 Oryctolagus cuniculus
100357806 Oryctolagus cuniculus
22223 Mus musculus
7345 Homo sapiens
29545 Rattus norvegicus
514394 Bos taurus
100714582 Cavia porcellus
396637 Sus scrofa
100033838 Equus caballus
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