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Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) Proteins (UCHL1)

The protein encoded by UCHL1 belongs to the peptidase C12 family. Additionally we are shipping UCHL1 Antibodies (341) and UCHL1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UCHL1 22223 Q9R0P9
UCHL1 7345 P09936
UCHL1 29545 Q00981
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Top UCHL1 Proteins at antibodies-online.com

Showing 10 out of 40 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 16 Days
$173.80
Details
HOST_Escherichia coli (E. coli) Rat His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$357.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 1-222), (partial) protein (His tag) 50 μg Log in to see 9 to 11 Days
$217.80
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$313.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$753.50
Details

UCHL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Top referenced UCHL1 Proteins

  1. Human UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN2181887 : Liu, Fallon, Lashuel, Liu, Lansbury: The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. in Cell 2002 (PubMed)
    Show all 3 references for ABIN2181887

  2. Rat (Rattus) UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN2009143 : Wada, Kito, Caskey, Yeh, Kamitani: Cleavage of the C-terminus of NEDD8 by UCH-L3. in Biochemical and biophysical research communications 1998 (PubMed)
    Show all 3 references for ABIN2009143

  3. Human UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN2004494 : Choi, Levey, Weintraub, Rees, Gearing, Chin, Li: Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN2004494

  4. Mouse (Murine) UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN2008165 : Lombardino, Li, Hertel, Nottebohm: Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 3 references for ABIN2008165

  5. Human UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN667048 : Sakurai, Ayukawa, Setsuie, Nishikawa, Hara, Ohashi, Nishimoto, Abe, Kudo, Sekiguchi, Sato, Aoki, Noda, Wada: Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation. in Journal of cell science 2005 (PubMed)
    Show all 2 references for ABIN667048

More Proteins for Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Interaction Partners

Mouse (Murine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (show RAB1A Proteins)-induced transformation of, germinal center B cells.

  2. Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (show SMN1 Proteins). Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA (show SMN1 Proteins).

  3. Parkin (show PARK2 Proteins) mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13 (show UBE2N Proteins)/Uev1a E2 ubiquitin-conjugating enzyme (show UBE2L6 Proteins) complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway.

  4. defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM

  5. UCH-L1 facilitates PDGF (show PDGFA Proteins)-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts

  6. UCHL1 upregulation in ACTN4 (show ACTN4 Proteins)-associated FSGS (show ACTN4 Proteins).

  7. downregulated miR (show MLXIP Proteins)-181b induces neuroprotection against ischemic injury through negatively regulating HSPA5 (show HSPA5 Proteins) and UCHL1 protein levels

  8. The proteases HtrA2/Omi (show HTRA2 Proteins) and UCH-L1 regulate TNF (show TNF Proteins)-induced necroptosis.

  9. Activation of the NF-kappaB (show NFKB1 Proteins) signaling pathway could be the major pathogenic mechanism to up-regulate UCH-L1 in podocyte injury.

  10. in AD, Abeta (show APP Proteins) may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF (show BDNF Proteins)/TrkB (show NTRK2 Proteins)-mediated retrograde signaling, compromising synaptic plasticity and neuronal survival.

Human Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. Folloing aneurysmal subarachnoid hemorrhage, eleevated UCH-L1 levels during the five-day follow-up were associated with unfavorable neurological outcome.

  2. UCH-L1 plays a crucial role in modulating the degradation of EGFR (show EGFR Proteins) and promoting malignant properties in multi-drug resistant breast cancer

  3. High UCHL1 expression is associated with multiple myeloma.

  4. The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (show RAB1A Proteins)-induced transformation of, germinal center B cells.

  5. The promoter methylation degree of FLNC (show FLNC Proteins), THBS1 (show THBS1 Proteins), UCHL1, and DLEC1 in serum could tell the existence of GC and only UCHL1 in the serum was also associated with poor prognosis of GC.

  6. The results of this study suggest the role for UCHL1 in promoting Corticospinal motor neurons health and stability.

  7. UCH-L1 is significantly associated with outcome, but it does not add predictive power to commonly used prognostic variables in a population of patients with TBI (show TBPL1 Proteins) of varying severities.

  8. Serum UCH-l1 levels serve as a novel biomarker for neuronal damage from white matter lesions.

  9. High Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4 (show NOX4 Proteins).

  10. These findings demonstrated that UCHL1 promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity by activating Akt and Erk1/2 pathways

Cow (Bovine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of cortical granules.

Pig (Porcine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA.

  2. Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM.

Horse (Equine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. There was no difference in enteric neuronal density and distribution in the groups of animals with intestinal disease compared with those without, apart from two (out of 28) horses with intestinal disease that showed reduction in PGP 9.5 immunoreactivity.

UCHL1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.

Gene names and symbols associated with UCHL1

  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1)
  • Ubiquitin carboxyl-terminal hydrolase isozyme L1 (uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100304750)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100348287)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100357806)
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (Uchl1)
  • AW822034 protein
  • C88048 protein
  • cb358 protein
  • gad protein
  • MGC132191 protein
  • PARK5 protein
  • PGP9.5 protein
  • PGP 9.5 protein
  • PGP95 protein
  • R75593 protein
  • Uch-L1 protein
  • UCHL-1 protein
  • uchl1 protein
  • wu:fc55h08 protein

Protein level used designations for UCHL1

ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) , ubiquitin carboxyl-terminal esterase L1 , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin thioesterase L1 , ubiquitin C-terminal hydrolase , PGP 9.5 , PGP9.5 , UCH-L1 , ubiquitin carboxy-terminal hydrolase L1 , ubiquitin C-terminal hydrolase-L1 , ubiquitin carboxyl-terminal hydrolase L1 , ubiquitin thiolesterase L1

GENE ID SPECIES
325119 Danio rerio
461185 Pan troglodytes
479098 Canis lupus familiaris
751589 Taeniopygia guttata
770302 Gallus gallus
496780 Xenopus (Silurana) tropicalis
735204 Xenopus laevis
100196868 Salmo salar
100304750 Ictalurus punctatus
100348287 Oryctolagus cuniculus
100357806 Oryctolagus cuniculus
22223 Mus musculus
7345 Homo sapiens
29545 Rattus norvegicus
514394 Bos taurus
100714582 Cavia porcellus
396637 Sus scrofa
100033838 Equus caballus
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