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Ubiquitin Carboxyl-terminal Hydrolase L5 Proteins (UCHL5)

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Additionally we are shipping UCHL5 Antibodies (91) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UCHL5 56207 Q9WUP7
UCHL5 51377 Q9Y5K5
Rat UCHL5 UCHL5 360853  
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Top UCHL5 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$383.25
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Cow His tag 100 μg Log in to see 11 to 13 Days
$880.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,883.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details

UCHL5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

Top referenced UCHL5 Proteins

  1. Human UCHL5 Protein expressed in Escherichia coli (E. coli) - ABIN667457 : Nishio, Kim, Kawai, Mizushima, Yamane, Hamazaki, Murata, Tanaka, Morimoto: Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain. in Biochemical and biophysical research communications 2009 (PubMed)
    Show all 2 references for ABIN667457

  2. Human UCHL5 Protein expressed in Wheat germ - ABIN1324519 : Nishi, Wijnhoven, le Sage, Tjeertes, Galanty, Forment, Clague, Urbé, Jackson: Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. in Nature cell biology 2014 (PubMed)

More Proteins for Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) Interaction Partners

Mouse (Murine) Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein deubiquitination, p21(WAF1 (show CDKN1A Proteins)) and fibronectin (show FN1 Proteins) protein expression and cell hypertrophy.

  2. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 (show USP14 Proteins) or Uch37 to activate ATP hydrolysis and enhance their own destruction

  3. this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis

Human Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. this work implicates hRpn13 (show Adrm1 Proteins) and Uch37 in cell cycle progression, providing a rationale for their function in cellular proliferation and for the apoptotic effect of the hRpn13 (show Adrm1 Proteins)-targeting molecule RA190.

  2. These results uncover a novel mechanism for E2F1 (show E2F1 Proteins) transcriptional activation through removal of its Lys (show LYZ Proteins)-63-linked ubiquitination by UCH37.

  3. Uch37 consists of two domains, a globular UCH-domain and a fibrous C-terminal tail. The C-terminal residues of Uch37 are implicated in Rpn13 binding.

  4. Data show that DEUBAD domain in RPN13 (ADRM1 (show Adrm1 Proteins)) activates ubiquitin thioesterase L5 (UCH-L5), and the related DEUBAD domain in INO80G (NFRKB (show NFRKB Proteins)) inhibits UCH-L5.

  5. Data indicate that ubiquitin thioesterase L5 UCH37 (UCHL5) comprises a catalytic UCH domain followed by the four-helix (alpha8-alpha11) C-terminal domain.

  6. High expression of UCH37 is significantly associated with epithelial ovarian cancer.

  7. b-AP15 is an inhibitor of deubiquitylating enzyme USP14 (show USP14 Proteins) and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

  8. UCH37 over-expression is associated with hepatocellular carcinoma recurrence.

  9. UCH37 is associated with outcome and recurrence of ESCC and can be a novel predictor for poor prognosis of esophageal squamous cell carcinoma patients after curative resection.

  10. a functional proteomic analysis was performed to screen UCH37-interacting proteins in hepatocellular carcinoma (HCC (show FAM126A Proteins)), and glucose-regulated protein 78 (show HSPA5 Proteins) was identified as one interacting with UCH37

Cow (Bovine) Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. Neither Uch37 alone nor the Uch37-Adrm1 (show Adrm1 Proteins) or Uch37-Adrm1 (show Adrm1 Proteins)-S1 complexes can hydrolyse di-ubiquitin efficiently; rather, incorporation into the 19S complex is required to enable processing of polyubiquitin (show UBB Proteins) chains.

UCHL5 Protein Profile

Protein Summary

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex\; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).

Gene names and symbols associated with UCHL5

  • ubiquitin carboxyl-terminal hydrolase L5 (uchl5)
  • ubiquitin carboxyl-terminal hydrolase L5 (UCHL5)
  • ubiquitin carboxyl-terminal esterase L5 (Uchl5)
  • ubiquitin carboxyl-terminal hydrolase L5 (Uchl5)
  • 5830413B11Rik protein
  • CGI-70 protein
  • DKFZp459M0513 protein
  • INO80R protein
  • UCH-L5 protein
  • UCH37 protein
  • wu:fj17f09 protein
  • zgc:85615 protein

Protein level used designations for UCHL5

ubiquitin carboxyl-terminal hydrolase isozyme L5 , ubiquitin carboxyl-terminal hydrolase L5 , UCH-L5 , ubiquitin C-terminal hydrolase 37 , ubiquitin C-terminal hydrolase UCH37 , ubiquitin thioesterase L5 , INO80 complex subunit R , ubiquitin carboxyl-terminal esterase L5

GENE ID SPECIES
406357 Danio rerio
424359 Gallus gallus
457596 Pan troglodytes
478958 Canis lupus familiaris
733154 Xenopus laevis
100124308 Xenopus (Silurana) tropicalis
100174635 Pongo abelii
100195039 Salmo salar
100349016 Oryctolagus cuniculus
56207 Mus musculus
51377 Homo sapiens
360853 Rattus norvegicus
282110 Bos taurus
100144472 Sus scrofa
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