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Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Additionally we are shipping UCHL5 Antibodies (96) and many more products for this protein.
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Human UCHL5 Protein expressed in Escherichia coli (E. coli) - ABIN667457
Nishio, Kim, Kawai, Mizushima, Yamane, Hamazaki, Murata, Tanaka, Morimoto: Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain. in Biochemical and biophysical research communications 2009
Show all 2 references for ABIN667457
Human UCHL5 Protein expressed in Wheat germ - ABIN1324519
Nishi, Wijnhoven, le Sage, Tjeertes, Galanty, Forment, Clague, Urbé, Jackson: Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. in Nature cell biology 2014
PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein deubiquitination, p21(WAF1 (show CDKN1A Proteins)) and fibronectin (show FN1 Proteins) protein expression and cell hypertrophy.
ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 (show USP14 Proteins) or Uch37 to activate ATP hydrolysis and enhance their own destruction
this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
this work implicates hRpn13 (show Adrm1 Proteins) and Uch37 in cell cycle progression, providing a rationale for their function in cellular proliferation and for the apoptotic effect of the hRpn13 (show Adrm1 Proteins)-targeting molecule RA190.
These results uncover a novel mechanism for E2F1 (show E2F1 Proteins) transcriptional activation through removal of its Lys (show LYZ Proteins)-63-linked ubiquitination by UCH37.
Uch37 consists of two domains, a globular UCH-domain and a fibrous C-terminal tail. The C-terminal residues of Uch37 are implicated in Rpn13 binding.
Data show that DEUBAD domain in RPN13 (ADRM1 (show Adrm1 Proteins)) activates ubiquitin thioesterase L5 (UCH-L5), and the related DEUBAD domain in INO80G (NFRKB (show NFRKB Proteins)) inhibits UCH-L5.
Data indicate that ubiquitin thioesterase L5 UCH37 (UCHL5) comprises a catalytic UCH domain followed by the four-helix (alpha8-alpha11) C-terminal domain.
High expression of UCH37 is significantly associated with epithelial ovarian cancer.
b-AP15 is an inhibitor of deubiquitylating enzyme USP14 (show USP14 Proteins) and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
UCH37 over-expression is associated with hepatocellular carcinoma recurrence.
UCH37 is associated with outcome and recurrence of ESCC and can be a novel predictor for poor prognosis of esophageal squamous cell carcinoma patients after curative resection.
a functional proteomic analysis was performed to screen UCH37-interacting proteins in hepatocellular carcinoma (HCC (show FAM126A Proteins)), and glucose-regulated protein 78 (show HSPA5 Proteins) was identified as one interacting with UCH37
Neither Uch37 alone nor the Uch37-Adrm1 (show Adrm1 Proteins) or Uch37-Adrm1 (show Adrm1 Proteins)-S1 complexes can hydrolyse di-ubiquitin efficiently; rather, incorporation into the 19S complex is required to enable processing of polyubiquitin (show UBB Proteins) chains.
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex\; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).
ubiquitin carboxyl-terminal hydrolase isozyme L5
, ubiquitin carboxyl-terminal hydrolase L5
, ubiquitin C-terminal hydrolase 37
, ubiquitin C-terminal hydrolase UCH37
, ubiquitin thioesterase L5
, INO80 complex subunit R
, ubiquitin carboxyl-terminal esterase L5