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UBR2 encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Additionally we are shipping UBR2 Antibodies (58) and UBR2 Kits (1) and many more products for this protein.
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There was a significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) observed in this research that could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.
Study provides functional data for the mouse ubiquitin protein ligase E3 component n-recognin 2 protein.
These data suggest that Tex19.1 and Ubr2 are required for mouse spermatocytes to accumulate sufficient Spo11 (show SPO11 Proteins)-dependent recombination to ensure that the homology search is consistently successful, and reveal a hitherto unknown genetic pathway promoting meiotic recombination in mammals.
Results suggest that UBR2 up-regulation in cachectic muscle is mediated by the p38beta (show MAPK11 Proteins)-C/EBPbeta (show CEBPB Proteins) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway.
insufficiency in UBR2-dependent histone ubiquitination triggers a pachytene checkpoint system, providing a new insight into chromatin remodeling and gene expression regulation
UBR2 ubiquitin ligase and the N-end rule pathway are required for male meiosis and spermatogenesis and for an essential aspect of female embryonic development.
mouse fibroblast cells derived from Ubr2 deficient embryos display genome instability.
UBR1 (show UBR1 Proteins)-/-UBR2-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.
This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.
ubiquitin protein ligase E3 component n-recognin 2
, E3 ubiquitin-protein ligase UBR2
, ubiquitin-protein ligase E3-alpha-2
, ubiquitin-protein ligase E3-alpha-II
, ubiquitin ligase E3 alpha-II