Ubiquitin Protein Ligase E3 Component N-Recognin 1 Proteins (UBR1)

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. Additionally we are shipping UBR1 Antibodies (54) and UBR1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBR1 197131 Q8IWV7
UBR1 22222 O70481
UBR1 499877  
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Top UBR1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

UBR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)
Rat (Rattus)

More Proteins for Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) Interaction Partners

Human Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. Reduced UBR1 expression affects MGMT (show MGMT Proteins) turnover and DNA repair in the smokers lungs.

  2. For all previously reported and novel UBR1 mutations together with their clinical data, a mutation database has been established at LOVD.

  3. Testing the fetus and the affected sibling with recurrent Johanson-Blizzard syndrome revealed a homozygous truncating mutation in UBR1.

  4. Results confirmed the relevance of specific missense UBR1 alleles to JBS, and suggested that a residual activity of a missense allele is causally associated with milder variants of JBS.

  5. Molecular studies revealed a novel homozygous nonsense mutation in exon 38 of the UBR1 gene, which confirmed the diagnosis of Johanson-Blizzard syndrome.

  6. Ubc2 (show ube2a Proteins)/Rad6 ser (show SIGLEC1 Proteins)(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1

  7. Deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway.

  8. Sustained ERK5 activity and the E3 ligase UBR1 regulate the stability and subcellular localization of c-Fos.

  9. Thus we propose that autoISGylation of EFP (show TRIM25 Proteins) negatively regulates its ISG15 (show ISG15 Proteins) E3 ligase activity for 14-3-3sigma.

  10. These results suggest that Rabring7 (show RNF115 Proteins) is involved in the endocytic trafficking of EGFR (show EGFR Proteins) through its E3 ligase activity.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) interaction partners

  1. involved in learning and memory; behavioral characterizations of UBR1 knockout mice

  2. UBR1-/-UBR2 (show UBR2 Proteins)-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.

  3. TLX1/HOX11 (show TLX1 Proteins) overexpression and Ubr1 inactivation in promoting chromosome missegregation, permitting the accrual of additional chromosome losses and cytogenic abnormalities en route to malignancy

  4. A STAT3 (show STAT3 Proteins)-dependent E3 ubiquitin ligase (show MUL1 Proteins), Ubr1, was responsible for rhodopsin degradation and was up-regulated in the inflamed SOCS3 (show SOCS3 Proteins)-deficient retinas.

UBR1 Protein Profile

Protein Summary

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Gene names and symbols associated with UBR1

  • CG9086 gene product from transcript CG9086-RB (CG9086)
  • ubiquitin protein ligase E3 component n-recognin 1 (ubr1)
  • ubiquitin protein ligase E3 component n-recognin 1 (UBR1)
  • Protein UBR-1 (ubr-1)
  • ubiquitin protein ligase E3 component n-recognin 1 (Ubr1)
  • AI504731 protein
  • Dmel\\CG9086 protein
  • JBS protein
  • RGD1562326 protein
  • UBR1 protein

Protein level used designations for UBR1

CG9086-PA , CG9086-PB , ubiquitin protein ligase E3 component n-recognin 1 , E3 ubiquitin-protein ligase UBR1 , E3a ligase , N-recognin-1 , ubiquitin ligase E3 alpha-I , ubiquitin-protein ligase E3-alpha , ubiquitin-protein ligase E3-alpha-1 , ubiquitin-protein ligase E3-alpha-I , E3 alpha , ubiquitin-protein ligase e3 componen n-recognin

32687 Drosophila melanogaster
568531 Danio rerio
100010751 Monodelphis domestica
100056497 Equus caballus
100511299 Sus scrofa
100558444 Anolis carolinensis
171953 Caenorhabditis elegans
197131 Homo sapiens
22222 Mus musculus
487521 Canis lupus familiaris
522464 Bos taurus
499877 Rattus norvegicus
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