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E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Additionally we are shipping UBE3C Antibodies (21) and many more products for this protein.
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data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7 (show ANXA7 Proteins), and thus presents a novel and promising target for glioma therapy.
these observations suggest that UBE3C plays an important role in RCC (show XRCC1 Proteins) development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC.
UBE3C is a mutant candidate oncogene (show RAB1A Proteins) involved in tumor development and progression of hepatocellular carcinoma.
knockdown renders cells more susceptible to the Hsp90 (show HSP90 Proteins) inhibitor 17-AAG (show MPG Proteins), suggesting that UBE3C protects against the harmful accumulation of protein fragments arising from incompletely degraded proteasome substrates.
Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics.
negatively regulates type I interferon (show IFNA Proteins) through ubiquitination of the transcription factors
TIP120B (show CAND2 Proteins) is a specific substrate of KIAA10; both are highly expressed in human skeletal muscle, suggesting that KIAA10 may regulate TIP120B (show CAND2 Proteins) homeostasis specifically in this tissue.
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
ubiquitin-protein ligase E3C
, ubiquitin protein ligase E3C
, ubiquitin-protein isopeptide ligase (E3)
, ubiquitin-protein ligase E3C-like