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USP1 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Additionally we are shipping USP1 Proteins (5) and many more products for this protein.
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Human Polyclonal USP1 Primary Antibody for EIA, IHC (p) - ABIN357518
Fujiwara, Saito, Suzuki, Shinomiya, Suzuki, Takahashi, Tanigami, Ichiyama, Chung, Nakamura, Tanaka: Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. in Genomics 1999
Show all 2 references for ABIN357518
Translational regulation of the mRNA encoding USP1 is involved in the DNA damage response as a determinant of cisplatin resistance.
Ubiquitination-specific proteases 1 (USP1)-mediated protein stabilization promotes glioblastoma (GBM) stem-like cells maintenance and treatment resistance, thereby providing a rationale for USP1 inhibition as a potential therapeutic approach against GBM.
analysis of the function and regulation of the USP1-UAF1 (show WDR48 Antibodies) complex
USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review)
No correlation was observed between the protein level of ubiquitin-specific protease 1 (USP1) and ubiquitinated PCNA (show PCNA Antibodies) in BAF180 (show PBRM1 Antibodies) expressing cells
USP1 phosphorylation at S313 is not critical for PCNA (show PCNA Antibodies) deubiquitination, neither for binding to UAF1 (show WDR48 Antibodies) in a cellular environment.
Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 (show WDR48 Antibodies) and any one of these three USPs: USP1, USP12 (show USP12 Antibodies) and USP46 (show USP46 Antibodies).
Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1
USP1 and UAF1 (show WDR48 Antibodies) form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 nuclear localization signals.
data identified a novel USP1-PHLPP1 (show PHLPP1 Antibodies)-Akt (show AKT1 Antibodies) signaling axis, and decreased USP1 level in lung cancer cells may play an important role in lung cancer progress.
our results strongly suggest that Usp1 is involved in the regulation of centrosome duplication, at least in part via ID1 (show ID1 Antibodies), and Usp1 may exert its oncogenic activity, partially through inducing centrosome abnormality.
Data suggest Usp1 down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 (Fanconi anemia complementation group D2 (show FANCD2 Antibodies)) and Pcna (proliferating cell nuclear antigen (show PCNA Antibodies)).
Homozygous Uaf1 (show WDR48 Antibodies)(-/-) embryos died at embryonic day 7.5 (E7.5). These mutant embryos were small and developmentally retarded.
Autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1, an enhancer of Usp1 activity, until the C-terminal fragment is selectively destroyed by the Arg/N-end rule pathway.
Bone marrow from Fancd2 (show FANCD2 Antibodies)-/- mice and Usp1-/- mice exhibited marked hematopoietic defects.
mouse Usp1 functions downstream in the Fanconi anemia (show PALB2 Antibodies) pathway, and its deubiquitination is required for Fancd2 (show FANCD2 Antibodies) nuclear foci assembly
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.
ubiquitin carboxyl-terminal hydrolase 1
, ubiquitin specific protease 1
, ubiquitin specific peptidase 1
, ubiquitin carboxyl-terminal hydrolase 1-like
, deubiquitinating enzyme 1
, ubiquitin carboxyl terminal hydrolase 1
, ubiquitin specific processing protease 1
, ubiquitin thioesterase 1
, ubiquitin thiolesterase 1
, ubiquitin-specific-processing protease 1
, ubiquitin specific peptdiase 1