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Ubiquitin Specific Peptidase 1 Proteins (USP1)

USP1 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Additionally we are shipping USP1 Antibodies (88) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP1 7398 O94782
Mouse USP1 USP1 230484 Q8BJQ2
USP1 313387 Q569C3
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Top USP1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Fungus His tag   1 mg Log in to see 56 to 66 Days
$2,159.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,301.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

USP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

More Proteins for Ubiquitin Specific Peptidase 1 (USP1) Interaction Partners

Human Ubiquitin Specific Peptidase 1 (USP1) interaction partners

  1. Translational regulation of the mRNA encoding USP1 is involved in the DNA damage response as a determinant of cisplatin resistance.

  2. Ubiquitination-specific proteases 1 (USP1)-mediated protein stabilization promotes glioblastoma (GBM) stem-like cells maintenance and treatment resistance, thereby providing a rationale for USP1 inhibition as a potential therapeutic approach against GBM.

  3. analysis of the function and regulation of the USP1-UAF1 (show WDR48 Proteins) complex

  4. USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review)

  5. No correlation was observed between the protein level of ubiquitin-specific protease 1 (USP1) and ubiquitinated PCNA (show PCNA Proteins) in BAF180 (show PBRM1 Proteins) expressing cells

  6. USP1 phosphorylation at S313 is not critical for PCNA (show PCNA Proteins) deubiquitination, neither for binding to UAF1 (show WDR48 Proteins) in a cellular environment.

  7. Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 (show WDR48 Proteins) and any one of these three USPs: USP1, USP12 (show USP12 Proteins) and USP46 (show USP46 Proteins).

  8. Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1

  9. USP1 and UAF1 (show WDR48 Proteins) form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 nuclear localization signals.

  10. data identified a novel USP1-PHLPP1-Akt (show AKT1 Proteins) signaling axis, and decreased USP1 level in lung cancer cells may play an important role in lung cancer progress.

Mouse (Murine) Ubiquitin Specific Peptidase 1 (USP1) interaction partners

  1. Data suggest Usp1 down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 (Fanconi anemia complementation group D2) and Pcna (proliferating cell nuclear antigen (show PCNA Proteins)).

  2. Homozygous Uaf1 (show WDR48 Proteins)(-/-) embryos died at embryonic day 7.5 (E7.5). These mutant embryos were small and developmentally retarded.

  3. Autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1, an enhancer of Usp1 activity, until the C-terminal fragment is selectively destroyed by the Arg/N-end rule pathway.

  4. Bone marrow from Fancd2-/- mice and Usp1-/- mice exhibited marked hematopoietic defects.

  5. mouse Usp1 functions downstream in the Fanconi anemia pathway, and its deubiquitination is required for Fancd2 nuclear foci assembly

USP1 Protein Profile

Protein Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

Gene names and symbols associated with USP1

  • ubiquitin specific peptidase 1 (USP1)
  • ubiquitin specific peptidase 1 (usp1)
  • ubiquitin specific peptidase 1 (Usp1)
  • UBP protein
  • usp1-a protein

Protein level used designations for USP1

ubiquitin carboxyl-terminal hydrolase 1 , ubiquitin specific protease 1 , ubiquitin specific peptidase 1 , ubiquitin carboxyl-terminal hydrolase 1-like , deubiquitinating enzyme 1 , hUBP , ubiquitin carboxyl terminal hydrolase 1 , ubiquitin specific processing protease 1 , ubiquitin thioesterase 1 , ubiquitin thiolesterase 1 , ubiquitin-specific-processing protease 1 , ubiquitin specific peptdiase 1

GENE ID SPECIES
100070397 Equus caballus
447465 Xenopus laevis
456901 Pan troglodytes
695157 Macaca mulatta
100443075 Pongo abelii
7398 Homo sapiens
230484 Mus musculus
313387 Rattus norvegicus
424685 Gallus gallus
479549 Canis lupus familiaris
100523071 Sus scrofa
516328 Bos taurus
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