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Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) Proteins (USP13)

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Additionally we are shipping USP13 Antibodies (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP13 8975 Q92995
Mouse USP13 USP13 72607 Q5BKP2
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Top USP13 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

USP13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) Interaction Partners

Human Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) interaction partners

  1. Down-regulation of USP13 mediates PTEN protein loss and fibroblast phenotypic change, and thereby plays a crucial role in idiopathic pulmonary fibrosis pathogenesis.

  2. The authors identify USP13 as a gp78 (show AMFR Proteins)-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A (show UBL4A Proteins) to maintain the functionality of Bag6 (show BAT3 Proteins).

  3. USP13 is a tumour-suppressing protein that functions through deubiquitylation and stabilization of PTEN.

  4. to our knowledge, USP13 is the first deubiquitinating enzymes identified to modulate STAT1 and play a role in the antiviral activity of IFN against DEN-2 replication.

  5. USP10 (show USP10 Proteins) mediates the deubiquitination of p53 (show TP53 Proteins), regulating deubiquitination activity of USP10 (show USP10 Proteins) and USP13 by Beclin1 (show BECN1 Proteins) provides a mechanism for Beclin1 (show BECN1 Proteins) to control the levels of p53 (show TP53 Proteins).

  6. Through deubiquitination, USP13 stabilizes and upregulates MITF (show MITF Proteins) protein levels.

  7. study identifies a new layer of Siah2 (show SIAH2 Proteins) regulation mediated by USP13 binding to ubiquitinated Siah2 (show SIAH2 Proteins) protein with a concomitant inhibitory effect on its activity under normoxia

USP13 Protein Profile

Protein Summary

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro\; however, additional experiments are required to confirm such data (By similarity).

Gene names and symbols associated with USP13

  • ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13)
  • ubiquitin specific peptidase 13 (isopeptidase T-3) (usp13)
  • universal stress protein (usp13)
  • ubiquitin specific peptidase 13 (isopeptidase T-3) (Usp13)
  • 2700071E21Rik protein
  • AI848077 protein
  • IsoT-3 protein
  • ISOT3 protein

Protein level used designations for USP13

ubiquitin specific peptidase 13 (isopeptidase T-3) , ubiquitin specific protease 13 (isopeptidase T-3) , ubiquitin carboxyl-terminal hydrolase 13-like , ubiquitin thiolesterase 13-like , deubiquitinating enzyme 13 , ubiquitin carboxyl-terminal hydrolase 13 , ubiquitin thioesterase 13 , ubiquitin-specific-processing protease 13 , ubiquitin thiolesterase 13 , universal stress protein , isopeptidase T-3 , Deubiquitinating enzyme 13 , Ubiquitin thioesterase 13 , Ubiquitin-specific-processing protease 13

GENE ID SPECIES
471009 Pan troglodytes
100524109 Sus scrofa
100346991 Oryctolagus cuniculus
429286 Gallus gallus
496675 Xenopus (Silurana) tropicalis
708624 Macaca mulatta
100013861 Monodelphis domestica
100484573 Ailuropoda melanoleuca
100563917 Anolis carolinensis
3127112 Haloarcula marismortui ATCC 43049
8975 Homo sapiens
72607 Mus musculus
478640 Canis lupus familiaris
100065844 Equus caballus
100141289 Bos taurus
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