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Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) Proteins (USP14)

USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Additionally we are shipping USP14 Antibodies (79) and USP14 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP14 59025 Q9JMA1
USP14 9097 P54578
Rat USP14 USP14 291796  
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Top USP14 Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$3,384.33
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$3,397.17
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,397.17
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$330.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

USP14 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced USP14 Proteins

  1. Human USP14 Protein expressed in Escherichia coli (E. coli) - ABIN1098518 : Mines, Goodwin, Limbird, Cui, Fan: Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN1098518

More Proteins for Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) (USP14) Interaction Partners

Mouse (Murine) Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) (USP14) interaction partners

  1. USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.

  2. Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.

  3. USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.

  4. Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.

  5. Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.

  6. miR (show MLXIP Proteins)-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.

  7. overexpression of HA-USP14 increased TNFalph (show TLR4 Proteins)a

  8. Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.

  9. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 (show UCHL5 Proteins) to activate ATP hydrolysis and enhance their own destruction

  10. USP14 has a role in regulating synaptic activity in mammals

Human Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) (USP14) interaction partners

  1. Increased USP14 expression in patients with breast cancer was associated with a poorer prognosis.

  2. Akt (show AKT1 Proteins)-mediated phosphorylation of USP14 at Ser432, which normally blocks its catalytic site in the inactive conformation, activates its deubiquitinating activity in vitro and in cells.

  3. our findings suggested that USP14 is involved in the progression of hepatocellular carcinoma(HCC (show FAM126A Proteins)) and may be a useful therapeutic target in HCC (show FAM126A Proteins)

  4. Cell surface ubiquitination precedes endocytosis, after which USP14 acts as an ubiquitin-binding protein that targets the ubiquitinated GABA B receptor to lysosomal degradation and promotes its deubiquitination.

  5. USP14 shows a marked preference for ubiquitin-cyclin B conjugates that carry more than one ubiquitin modification or chain

  6. our findings suggest that USP14 is involved in the progression of epithelial ovarian cancer

  7. Downregulation of USP14 expression arrested the cell cycle, which may be related to beta-catenin (show CTNNB1 Proteins) degradation.

  8. MiR (show MLXIP Proteins)-4782-3p inhibited cell proliferation in NSCLC by targeting USP14, ZEB2 and XIAP (show XIAP Proteins).

  9. b-AP15 is an inhibitor of deubiquitylating enzyme USP14 and UCHL5 (show UCHL5 Proteins) induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

  10. overexpression of HA-USP14 increased the LPS (show IRF6 Proteins)-, TNFalpha (show TNF Proteins)-, or Escherichia coli-induced IL-8 (show IL8 Proteins) release in human lung epithelial cells.

USP14 Protein Profile

Protein Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with USP14

  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (USP14)
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (usp14)
  • universal stress protein (usp14)
  • peptidase C19 family protein (usp14)
  • Protein USP-14 (usp-14)
  • ubiquitin specific peptidase 14 (Usp14)
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (Usp14)
  • 2610005K12Rik protein
  • 2610037B11Rik protein
  • AW107924 protein
  • ax protein
  • C78769 protein
  • DDBDRAFT_0202821 protein
  • DDBDRAFT_0237695 protein
  • DDB_0202821 protein
  • DDB_0237695 protein
  • MGC69343 protein
  • MGC81945 protein
  • TGT protein
  • USP14 protein

Protein level used designations for USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) , ubiquitin specific protease 14 (tRNA-guanine transglycosylase) , universal stress protein , ubiquitin domain-containing protein , ubiquitin carboxyl-terminal hydrolase 14-like , ataxia , dUB-type TGT for deubiquitinating enzyme , deubiquitinating enzyme 14 , ubiquitin carboxyl-terminal hydrolase 14 , ubiquitin specific protease 14 , ubiquitin thioesterase 14 , ubiquitin thiolesterase 14 , ubiquitin-specific-processing protease 14 , tRNA-guanine transglycosylase, 60-kD subunit , ubiquitin-specific processing protease 14 , queuine tRNA-ribosyltransferase

GENE ID SPECIES
100090009 Ornithorhynchus anatinus
421063 Gallus gallus
447733 Xenopus laevis
448110 Xenopus (Silurana) tropicalis
480182 Canis lupus familiaris
698087 Macaca mulatta
3130489 Haloarcula marismortui ATCC 43049
8617881 Dictyostelium discoideum AX4
100013535 Monodelphis domestica
100394297 Callithrix jacchus
100473541 Ailuropoda melanoleuca
100586916 Nomascus leucogenys
175105 Caenorhabditis elegans
59025 Mus musculus
505106 Bos taurus
9097 Homo sapiens
291796 Rattus norvegicus
100009078 Oryctolagus cuniculus
455325 Pan troglodytes
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