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USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Additionally we are shipping USP14 Antibodies (88) and USP14 Proteins (15) and many more products for this protein.
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USP14 promotes prostate cancer progression.
without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.
USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1 (show BECN1 ELISA Kits)
USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.
USP14 participates in CAM (show CALM1 ELISA Kits)-DR of MM through acting as a bridge between Bcl-xl (show BCL2L1 ELISA Kits) apoptotic pathway and Wnt (show WNT2 ELISA Kits)-signaling pathways and may be represented as a good candidate for pursuing clinical trials in MM.
Results show that USP14 mRNA is overexpressed in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) tissues and inversely correlates with miR (show MLXIP ELISA Kits)-4782-3p level which binds to USP14 3'UTR (show UTS2R ELISA Kits) to regulate its expression.
Results found USP14 amplification and overexpression in many different cancers. Its overexpression in low-expression cell lines promoted cell proliferation and migration, whereas its downregulation suppressed tumor cell proliferation, increased apoptosis rate, and decreased cell migration and invasion suggesting an oncogenic role in various types of cancer.
Increased USP14 expression in patients with breast cancer was associated with a poorer prognosis.
Akt-mediated phosphorylation of USP14 at Ser432, which normally blocks its catalytic site in the inactive conformation, activates its deubiquitinating activity in vitro and in cells.
our findings suggested that USP14 is involved in the progression of hepatocellular carcinoma(HCC (show FAM126A ELISA Kits)) and may be a useful therapeutic target in HCC (show FAM126A ELISA Kits)
USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.
Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.
USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.
Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.
Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.
miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.
overexpression of HA-USP14 increased TNFalpha (show TNF ELISA Kits)
Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.
ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 (show UCHL5 ELISA Kits) to activate ATP hydrolysis and enhance their own destruction
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme 14
, tRNA-guanine transglycosylase, 60-kD subunit
, ubiquitin carboxyl-terminal hydrolase 14
, ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
, ubiquitin thioesterase 14
, ubiquitin thiolesterase 14
, ubiquitin-specific processing protease 14
, ubiquitin-specific-processing protease 14
, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
, ubiquitin domain-containing protein
, dUB-type TGT for deubiquitinating enzyme
, ubiquitin specific protease 14
, universal stress protein
, queuine tRNA-ribosyltransferase
, ubiquitin carboxyl-terminal hydrolase 14-like