Ubiquitin Specific Peptidase 14 Proteins (USP14)

USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Additionally we are shipping USP14 Antibodies (88) and USP14 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP14 9097 P54578
USP14 59025 Q9JMA1
Rat USP14 USP14 291796  
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Top USP14 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$460.85
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$330.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$212.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 60 to 71 Days
$3,384.33
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 60 to 71 Days
$3,397.17
Details

USP14 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Ubiquitin Specific Peptidase 14 (USP14) Interaction Partners

Human Ubiquitin Specific Peptidase 14 (USP14) interaction partners

  1. Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma

  2. our report demonstrates significant value in targeting USP14/UCHL5 (show UCHL5 Proteins) with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  3. USP14 promotes prostate cancer progression.

  4. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  5. USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1 (show BECN1 Proteins)

  6. USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.

  7. USP14 participates in CAM-DR of MM through acting as a bridge between Bcl-xl (show BCL2L1 Proteins) apoptotic pathway and Wnt (show WNT2 Proteins)-signaling pathways and may be represented as a good candidate for pursuing clinical trials in MM.

  8. Results show that USP14 mRNA is overexpressed in hepatocellular carcinoma (HCC) tissues and inversely correlates with miR-4782-3p level which binds to USP14 3'UTR to regulate its expression.

  9. Results found USP14 amplification and overexpression in many different cancers. Its overexpression in low-expression cell lines promoted cell proliferation and migration, whereas its downregulation suppressed tumor cell proliferation, increased apoptosis rate, and decreased cell migration and invasion suggesting an oncogenic role in various types of cancer.

  10. Increased USP14 expression in patients with breast cancer was associated with a poorer prognosis.

Mouse (Murine) Ubiquitin Specific Peptidase 14 (USP14) interaction partners

  1. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  2. USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.

  3. Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.

  4. USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.

  5. Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.

  6. Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.

  7. miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.

  8. overexpression of HA-USP14 increased TNFalpha (show TNF Proteins)

  9. Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.

  10. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 (show UCHL5 Proteins) to activate ATP hydrolysis and enhance their own destruction

USP14 Protein Profile

Protein Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with USP14

  • ubiquitin specific peptidase 14 (USP14)
  • peptidase C19 family protein (usp14)
  • ubiquitin specific peptidase 14 (Usp14)
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (usp14)
  • ubiquitin specific protease 14 (Bm1_28765)
  • ubiquitin specific peptidase 14 S homeolog (usp14.S)
  • ubiquitin specific peptidase 14 (usp14)
  • universal stress protein (RR_RS06480)
  • Ubiquitin carboxyl-terminal hydrolase 14 (usp-14)
  • 2610005K12Rik protein
  • 2610037B11Rik protein
  • AW107924 protein
  • ax protein
  • C78769 protein
  • DDBDRAFT_0202821 protein
  • DDBDRAFT_0237695 protein
  • DDB_0202821 protein
  • DDB_0237695 protein
  • MGC69343 protein
  • MGC81945 protein
  • tgt protein
  • USP14 protein
  • wu:fk63d09 protein
  • zgc:55949 protein

Protein level used designations for USP14

deubiquitinating enzyme 14 , tRNA-guanine transglycosylase, 60-kD subunit , ubiquitin carboxyl-terminal hydrolase 14 , ubiquitin specific protease 14 (tRNA-guanine transglycosylase) , ubiquitin thioesterase 14 , ubiquitin thiolesterase 14 , ubiquitin-specific processing protease 14 , ubiquitin-specific-processing protease 14 , ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) , ubiquitin domain-containing protein , ataxia , dUB-type TGT for deubiquitinating enzyme , ubiquitin specific protease 14 , universal stress protein , queuine tRNA-ribosyltransferase , ubiquitin carboxyl-terminal hydrolase 14-like

GENE ID SPECIES
9097 Homo sapiens
100090009 Ornithorhynchus anatinus
8617881 Dictyostelium discoideum AX4
59025 Mus musculus
291796 Rattus norvegicus
335736 Danio rerio
455325 Pan troglodytes
505106 Bos taurus
6100653 Brugia malayi
421063 Gallus gallus
447733 Xenopus laevis
448110 Xenopus (Silurana) tropicalis
480182 Canis lupus familiaris
698087 Macaca mulatta
3130489 Haloarcula marismortui ATCC 43049
100009078 Oryctolagus cuniculus
100013535 Monodelphis domestica
100394297 Callithrix jacchus
100473541 Ailuropoda melanoleuca
100586916 Nomascus leucogenys
175105 Caenorhabditis elegans
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