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Ubiquitin Specific Peptidase 18 (USP18) ELISA Kits

The protein encoded by USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. Additionally we are shipping USP18 Antibodies (28) and USP18 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat USP18 USP18 312688  
Anti-Human USP18 USP18 11274 Q9UMW8
Anti-Mouse USP18 USP18 24110 Q9WTV6
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More ELISA Kits for USP18 Interaction Partners

Human Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. USP18 negatively regulates NF-kappaB (show NFKB1 ELISA Kits) signaling by targeting TAK1 (show MAP3K7 ELISA Kits) and NEMO (show IKBKG ELISA Kits) for deubiquitination through distinct mechanisms.

  2. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 (show SLC15A1 ELISA Kits) and PEPT2 (show SLC15A2 ELISA Kits).

  3. Dimerization of IFNAR1 (show IFNAR1 ELISA Kits) and IFNAR2 (show IFNAR2 ELISA Kits) and the limiting role of IFNAR1 (show IFNAR1 ELISA Kits) binding affinity in complex assembly is modulated by USP18.

  4. USP18 expression levels induced by IFNbeta did not differ amongst multiple sclerosis patients carrying different rs2542109 genotypes

  5. USP18 inhibition induces inflammation by increasing the STAT (show STAT1 ELISA Kits) signaling and exacerbates IFN-induced beta cell apoptosis.

  6. Usp18 upregulation was associated with Wilms Tumor.

  7. A direct relationship was found between UBP43 and cyclin D1 (show CCND1 ELISA Kits) (but not cyclin E (show CCNE1 ELISA Kits)) expression.

  8. USP18 establishes the transcriptional and anti-proliferative interferon alpha (show IFNA ELISA Kits)/beta differential

  9. USP18 is up-regulated in liver samples of patients with chronic hepatitis C that did not respond to therapy, but not in patients with acute hepatitis C.

  10. although UBP43 depletion can cause hypersensitivity to interferon-alpha (show IFNA ELISA Kits)/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type.

Pig (Porcine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. These data highlight USP18 as a host restriction factor during innate immune response to porcine respiratory and reproductive syndrome virus.

  2. USP18 is a potential target gene that promotes reduced replication of PRRSV.

  3. Results report identification and cloning of the ISG15 (show ISG15 ELISA Kits) and ISG43 genes in pig.

Mouse (Murine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy

  2. USP18 null mice develop leiomyosarcoma recapitulating key features of clinical leiomyosarcomas and patients with reduced-USP18 tumor levels have an unfavorable outcome.

  3. USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

  4. results suggest that increasing ISGylation by specific inhibition of USP18 protease activity could constitute a promising antiviral strategy with only a minimal risk of severe adverse effects

  5. USP18 is crucial for IFN-gamma (show IFNG ELISA Kits)-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.

  6. Usp18-driven enforced viral replication in dendritic cells can break immunological tolerance and critically influences induction of autoimmunity.

  7. Hypersensitivity of Usp18 knockout in mammary epithelial cells to IFN-gamma (show IFNG ELISA Kits) enhances Cxcl10 (show CXCL10 ELISA Kits) expression and protects against mammary tumour progression.

  8. USP18 inhibits NF-kappaB (show NFKB1 ELISA Kits) and NFAT (show NFATC1 ELISA Kits) activation during Th17 differentiation by deubiquitinating the TAK1 (show NR2C2 ELISA Kits)-TAB1 (show TAB1 ELISA Kits) complex.

  9. Usp18 upregulation was associated with Wilms Tumor.

  10. although UBP43 depletion can cause hypersensitivity to interferon-alpha (show IFNA ELISA Kits)/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type.

USP18 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

Gene names and symbols associated with USP18

  • ubiquitin specific peptidase 18 (Usp18) antibody
  • ubiquitin specific peptidase 18 (USP18) antibody
  • universal stress protein (usp18) antibody
  • 1110058H21Rik antibody
  • AW047653 antibody
  • bubp43 antibody
  • ISG43 antibody
  • UBP antibody
  • Ubp15 antibody
  • UBP43 antibody
  • USP18 antibody
  • USP41 antibody

Protein level used designations for USP18

ubl carboxyl-terminal hydrolase 18 , ubiquitin specific peptidase 18 , universal stress protein , ubiquitin specific protease 18 , ubiquitin specific peptidase 41 , 43 kDa ISG15-specific protease , ISG15-specific-processing protease , hUBP43 , ubl thioesterase 18 , ubl thiolesterase 18 , interferon-stimulated gene 43 , ubiquitin-specific protease 18 , ubiquitin specific protease 15

GENE ID SPECIES
312688 Rattus norvegicus
486763 Canis lupus familiaris
515202 Bos taurus
3128094 Haloarcula marismortui ATCC 43049
418167 Gallus gallus
100054488 Equus caballus
100583021 Nomascus leucogenys
11274 Homo sapiens
742929 Pan troglodytes
100171781 Pongo abelii
396777 Sus scrofa
24110 Mus musculus
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