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Ubiquitin Specific Peptidase 18 Proteins (USP18)

The protein encoded by USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. Additionally we are shipping USP18 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat USP18 USP18 312688  
USP18 11274 Q9UMW8
Mouse USP18 USP18 24110 Q9WTV6
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Top USP18 Proteins at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

USP18 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Ubiquitin Specific Peptidase 18 (USP18) Interaction Partners

Human Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. USP18 negatively regulates NF-kappaB (show NFKB1 Proteins) signaling by targeting TAK1 (show MAP3K7 Proteins) and NEMO (show IKBKG Proteins) for deubiquitination through distinct mechanisms.

  2. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2.

  3. Dimerization of IFNAR1 (show IFNAR1 Proteins) and IFNAR2 (show IFNAR2 Proteins) and the limiting role of IFNAR1 (show IFNAR1 Proteins) binding affinity in complex assembly is modulated by USP18.

  4. USP18 expression levels induced by IFNbeta did not differ amongst multiple sclerosis patients carrying different rs2542109 genotypes

  5. USP18 inhibition induces inflammation by increasing the STAT (show STAT1 Proteins) signaling and exacerbates IFN-induced beta cell apoptosis.

  6. Usp18 upregulation was associated with Wilms Tumor.

  7. A direct relationship was found between UBP43 and cyclin D1 (show CCND1 Proteins) (but not cyclin E (show CCNE1 Proteins)) expression.

  8. USP18 establishes the transcriptional and anti-proliferative interferon alpha (show IFNA Proteins)/beta differential

  9. USP18 is up-regulated in liver samples of patients with chronic hepatitis C that did not respond to therapy, but not in patients with acute hepatitis C.

  10. although UBP43 depletion can cause hypersensitivity to interferon-alpha (show IFNA Proteins)/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type.

Pig (Porcine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. These data highlight USP18 as a host restriction factor during innate immune response to porcine respiratory and reproductive syndrome virus.

  2. USP18 is a potential target gene that promotes reduced replication of PRRSV.

  3. Results report identification and cloning of the ISG15 (show ISG15 Proteins) and ISG43 genes in pig.

Mouse (Murine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy

  2. USP18 null mice develop leiomyosarcoma recapitulating key features of clinical leiomyosarcomas and patients with reduced-USP18 tumor levels have an unfavorable outcome.

  3. USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

  4. results suggest that increasing ISGylation by specific inhibition of USP18 protease activity could constitute a promising antiviral strategy with only a minimal risk of severe adverse effects

  5. USP18 is crucial for IFN-gamma (show IFNG Proteins)-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.

  6. Usp18-driven enforced viral replication in dendritic cells can break immunological tolerance and critically influences induction of autoimmunity.

  7. Hypersensitivity of Usp18 knockout in mammary epithelial cells to IFN-gamma (show IFNG Proteins) enhances Cxcl10 (show CXCL10 Proteins) expression and protects against mammary tumour progression.

  8. USP18 inhibits NF-kappaB (show NFKB1 Proteins) and NFAT (show NFATC1 Proteins) activation during Th17 differentiation by deubiquitinating the TAK1 (show NR2C2 Proteins)-TAB1 (show TAB1 Proteins) complex.

  9. Usp18 upregulation was associated with Wilms Tumor.

  10. although UBP43 depletion can cause hypersensitivity to interferon-alpha (show IFNA Proteins)/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type.

USP18 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

Gene names and symbols associated with USP18

  • ubiquitin specific peptidase 18 (Usp18)
  • ubiquitin specific peptidase 18 (USP18)
  • universal stress protein (usp18)
  • 1110058H21Rik protein
  • AW047653 protein
  • bubp43 protein
  • ISG43 protein
  • UBP protein
  • Ubp15 protein
  • UBP43 protein
  • USP18 protein
  • USP41 protein

Protein level used designations for USP18

ubl carboxyl-terminal hydrolase 18 , ubiquitin specific peptidase 18 , universal stress protein , ubiquitin specific protease 18 , ubiquitin specific peptidase 41 , 43 kDa ISG15-specific protease , ISG15-specific-processing protease , hUBP43 , ubl thioesterase 18 , ubl thiolesterase 18 , interferon-stimulated gene 43 , ubiquitin-specific protease 18 , ubiquitin specific protease 15

GENE ID SPECIES
312688 Rattus norvegicus
486763 Canis lupus familiaris
515202 Bos taurus
3128094 Haloarcula marismortui ATCC 43049
418167 Gallus gallus
100054488 Equus caballus
100583021 Nomascus leucogenys
11274 Homo sapiens
742929 Pan troglodytes
100171781 Pongo abelii
396777 Sus scrofa
24110 Mus musculus
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