anti-Ubiquitin Specific Peptidase 18 (USP18) Antibodies

The protein encoded by USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. Additionally we are shipping USP18 Proteins (4) and USP18 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USP18 312688  
USP18 11274 Q9UMW8
USP18 24110 Q9WTV6
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Top anti-USP18 Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-USP18 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate <b>Sample Type</b>: 2. mouse brain extracts (80ug)<br> <b>Primary Antibody Dilution:</b> 2ug/ml<br> <b>Secondary Antibody</b>: IRDye 800CW goat anti-rabbit from Li-COR Bioscience<br> <b>Secondary Antibody Dilution:</b> 1: 20,000<br> <b>Image Submitted by</b>: Yuzhi Chen<br> University of Arkansas for Medical Science 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chimpanzee Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$411.18
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human breast cancer, using USP18, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: IMR32 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB Western blot using Affinity Purified anti-UBP43 antibody shows detection of a band ~43 kDa band (arrowhead) believed to be to UBP43 in lysates from HeLa nuclear extracts (lane 1) and whole cell lysates from HeLa (lane 2), A431 (lane 3, Jurkat (Lane 4) and HEK293 (lane 5).  Approximately 18 µg of each lysate was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-UBP43 antibody. Signal was detected using standard techniques. The strong band between the 37kD and 50kD markers is expected to be UBP43. The other bands are probably non-specific. 100 μg Log in to see 1 to 2 Days
$379.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: USP18 Antibody [NBP1-33675] - Paraffin-embedded Breast ca, using antibody at 1:500 dilution. Western Blot: USP18 Antibody [NBP1-33675] - Analysis of USP18 on IMR32 lysates using NBP1-33675 at a dilution of 1:1000. 30ug whole cell lysate loaded on 10% SDS PAGE gel. 100 μL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB Human Heart (formalin-fixed, paraffin-embedded) stained with USP18 antibody ABIN213754 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB 0.05 mg Log in to see 2 to 3 Days
$515.63
Details

USP18 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)


Human ,
,
,
Mouse (Murine)


More Antibodies against USP18 Interaction Partners

Human Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. that Ubiquitin-specific peptidase 18 directly bind to BCL2L1 (show BCL2L1 Antibodies) and positively regulated its expression in hepatocellular carcinoma cells

  2. These findings add USP18 deficiency to the list of genetic disorders collectively termed type I interferonopathies

  3. We show that IRF-7 (show IRF7 Antibodies) siRNA knockdown enhanced LPS (show IRF6 Antibodies)-induced IL-10 (show IL10 Antibodies) production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS (show IRF6 Antibodies)-induced production of IL-10 (show IL10 Antibodies) in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10 (show IL10 Antibodies), and IRF7 (show IRF7 Antibodies). An independent cohort confirmed LPS (show IRF6 Antibodies) induction of USP41 and IL10 (show IL10 Antibodies) genes

  4. results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling pathway in Hepg2.2.15 cells.

  5. USP18's ISG15 (show ISG15 Antibodies) specificity is mediated by a small interaction interface.

  6. STAT2 (show STAT2 Antibodies) recruits USP18 to the type I IFN receptor subunit IFNAR2 (show IFNAR2 Antibodies) via its constitutive membrane-distal STAT2 (show STAT2 Antibodies)-binding site.

  7. findings show that multiple inflammatory stimuli can modulate interferon (show IFNA Antibodies) stimulated gene expression and thus inhibit hepatocyte interferon (show IFNA Antibodies) signaling via USP18 induction

  8. USP18 negatively regulates NF-kappaB (show NFKB1 Antibodies) signaling by targeting TAK1 (show MAP3K7 Antibodies) and NEMO (show IKBKG Antibodies) for deubiquitination through distinct mechanisms.

  9. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2 (show SLC15A2 Antibodies).

  10. Dimerization of IFNAR1 (show IFNAR1 Antibodies) and IFNAR2 (show IFNAR2 Antibodies) and the limiting role of IFNAR1 (show IFNAR1 Antibodies) binding affinity in complex assembly is modulated by USP18.

Pig (Porcine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. These data highlight USP18 as a host restriction factor during innate immune response to porcine respiratory and reproductive syndrome virus.

  2. USP18 is a potential target gene that promotes reduced replication of PRRSV.

  3. Results report identification and cloning of the ISG15 (show ISG15 Antibodies) and ISG43 genes in pig.

Mouse (Murine) Ubiquitin Specific Peptidase 18 (USP18) interaction partners

  1. this study identifies the osteopenia phenotype of mice lacking Usp18, which is known as a negative regulator of type I IFN signaling

  2. USP18 has a protective role in pathological cardiac remodeling in mouse.

  3. USP18's ISG15 (show ISG15 Antibodies) specificity is mediated by a small interaction interface.

  4. findings show that multiple inflammatory stimuli can modulate interferon (show IFNA Antibodies) stimulated gene expression and thus inhibit hepatocyte interferon (show IFNA Antibodies) signaling via USP18 induction

  5. Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy

  6. USP18 null mice develop leiomyosarcoma recapitulating key features of clinical leiomyosarcomas and patients with reduced-USP18 tumor levels have an unfavorable outcome.

  7. USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

  8. results suggest that increasing ISGylation by specific inhibition of USP18 protease activity could constitute a promising antiviral strategy with only a minimal risk of severe adverse effects

  9. USP18 is crucial for IFN-gamma (show IFNG Antibodies)-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.

  10. Usp18-driven enforced viral replication in dendritic cells can break immunological tolerance and critically influences induction of autoimmunity.

USP18 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

Gene names and symbols associated with USP18

  • ubiquitin specific peptidase 18 (Usp18) antibody
  • ubiquitin specific peptidase 18 (USP18) antibody
  • universal stress protein (usp18) antibody
  • 1110058H21Rik antibody
  • AW047653 antibody
  • bubp43 antibody
  • ISG43 antibody
  • UBP antibody
  • Ubp15 antibody
  • UBP43 antibody
  • USP18 antibody
  • USP41 antibody

Protein level used designations for USP18

ubl carboxyl-terminal hydrolase 18 , ubiquitin specific peptidase 18 , universal stress protein , ubiquitin specific protease 18 , ubiquitin specific peptidase 41 , 43 kDa ISG15-specific protease , ISG15-specific-processing protease , hUBP43 , ubl thioesterase 18 , ubl thiolesterase 18 , interferon-stimulated gene 43 , ubiquitin-specific protease 18 , ubiquitin specific protease 15

GENE ID SPECIES
312688 Rattus norvegicus
486763 Canis lupus familiaris
515202 Bos taurus
3128094 Haloarcula marismortui ATCC 43049
418167 Gallus gallus
100054488 Equus caballus
100583021 Nomascus leucogenys
11274 Homo sapiens
742929 Pan troglodytes
100171781 Pongo abelii
396777 Sus scrofa
24110 Mus musculus
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