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Deubiquitinating enzyme that regulates the degradation of various proteins. Additionally we are shipping USP19 Antibodies (54) and and many more products for this protein.
HRD1 (show SYVN1 ELISA Kits) is a novel substrate for USP19. USP19 negatively regulates the ubiquitination of HRD1 (show SYVN1 ELISA Kits) and prevents it from undergoing proteasomal degradation.
USP19 positively regulates autophagy and antiviral immune responses by deubiquitinating Beclin-1 (show BECN1 ELISA Kits).
In conjunction with HSP90 (show HSP90 ELISA Kits), the cytoplasmic USP19 may play a key role in triage decision for the disease-related polyQ-expanded substrates, suggesting a function of USP19 in quality control of misfolded proteins by regulating their protein levels
Expression of USP19 correlates with that of MuRF1 (show TRIM63 ELISA Kits) and MAFbx/atrogin-1 (show FBXO32 ELISA Kits) in skeletal muscles
These results clarify the role of USP19 in ERAD and suggest a novel DUB regulation that involves chaperone association and membrane integration
USP19 interacts with the ubiquitin ligases SIAH1 (show SIAH1 ELISA Kits) and SIAH2 (show SIAH2 ELISA Kits), which promote USP19 ubiquitylation and degradation by the proteasome.
experimentally verified the targets heterogeneous nuclear ribonucleoprotein U (show HNRNPU ELISA Kits), phosphatidylinositol-3-OH kinase, the WNK (with-no-lysine) kinase family and USP19 (ubiquitin-specific peptidase 19) as vulnerable nodes in the host cellular defence system against viruses
ubiquitin-specific protease-19 (USP19) interacts with components of the hypoxia pathway including HIF-1alpha (show HIF1A ELISA Kits) and rescues it from degradation independent of its catalytic activity
The USP19 deubiquitinase regulates the stability of c-IAP1 (show BIRC2 ELISA Kits) and c-IAP2 (show BIRC3 ELISA Kits).
ability of USP19 to regulate cell proliferation and p27(Kip1 (show CDKN1B ELISA Kits)) levels; complete loss of USP19 function on cell growth may arise as a result of oncogenic transformation of cells.
Deubiquitination by USP19 does modulate muscle cell differentiation and that this function requires the ER-localized isoform and appears to act through regulation of the unfolded-protein response (UPR) signaling.
Data suggest that, in young female mice, 17beta-estradiol upregulates USP19 expression through Esr1 (estrogen receptor alpha (show ESR1 ELISA Kits)) and leads to down-regulation of muscle mass and down-regulation of ubiquitination of muscle proteins.
E2 induces USP19 expression through nuclear ERalpha (show ESR1 ELISA Kits), (ii) increased USP19-mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta (show ESR2 ELISA Kits) inhibits ERalpha (show ESR1 ELISA Kits)-activated USP19 expression.
study reports that the USP19 deubiquitinating enzyme interacts with and stabilizes KPC1 (show RNF123 ELISA Kits), thereby modulating p27(Kip1 (show CDKN1B ELISA Kits)) levels and cell proliferation
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.
ubiquitin specific peptidase 19
, ubiquitin-specific protease 19
, ubiquitin specific protease 19
, universal stress protein
, ubiquitin carboxyl-terminal hydrolase 19
, ubiquitin carboxyl-terminal hydrolase 19-like
, deubiquitinating enzyme 19
, ubiquitin thioesterase 19
, ubiquitin thiolesterase 19
, ubiquitin-specific-processing protease 19
, zinc finger MYND domain-containing protein 9
, ubiquitin-specific processing protease 19