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anti-Ubiquitin Specific Peptidase 2 (USP2) Antibodies

USP2 encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. Additionally we are shipping USP2 Kits (7) and USP2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USP2 9099 O75604
USP2 53376 O88623
USP2 115771 Q5U349
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Top anti-USP2 Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB UBP46 Antibody (C-term) (ABIN658082) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the UBP46 antibody detected the UBP46 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-USP2 Antibody (C-term L523) (ABIN388879) in K562 cell line lysates (35 µg/lane).USP2(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB The anti-USP2 Antibody (C-term)(ABIN388878) is used in Western blot to detect USP2 in USP2-transfected HeLa cell lysates. Transfection data is kindly provided by Dr. B. Pierrat from the Novartis Institute for Biomedical Research (Basel, Switzerland). Western blot analysis of anti-USP2 Antibody (C-term) (ABIN388878) in HL60 cell line lysates (35 µg/lane).USP2(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of USP2 Antibody (N-term) (ABIN388877) in HL60 cell line lysates (35 µg/lane). USP2 (arrow) was detected using the purified polyclonal antibody. IHC for USP2a in a formalin-fixed, paraffin-embedded human prostate sample. Cytoplasmic positive immunostaining was detected in tumor glands (ii), whereas in normal prostatic epithelium, USP2a expression was restricted to the basal layer. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-USP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HCT15 cell lysate WB Suggested Anti-USP2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HCT15 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-USP2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain WB Suggested Anti-USP2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details

USP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine) , , ,


Rat (Rattus) , , ,


Top referenced anti-USP2 Antibodies

  1. Human Polyclonal USP2 Primary Antibody for IHC (p), WB - ABIN388879 : Stevenson, Sparks, Allende-Vega, Xirodimas, Lane, Saville: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. in The EMBO journal 2007 (PubMed)
    Show all 8 references for ABIN388879

  2. Human Polyclonal USP2 Primary Antibody for IHC (p), WB - ABIN388877 : Priolo, Tang, Brahamandan, Benassi, Sicinska, Ogino, Farsetti, Porrello, Finn, Zimmermann, Febbo, Loda: The isopeptidase USP2a protects human prostate cancer from apoptosis. in Cancer research 2006 (PubMed)
    Show all 3 references for ABIN388877

  3. Human Polyclonal USP2 Primary Antibody for WB - ABIN658082 : Kushima, Aleksic, Ito, Nakamura, Nakamura, Mori, Kikuchi, Inada, Kunugi, Nanko, Kato, Yoshikawa, Ujike, Suzuki, Iwata, Ozaki: Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population. in Journal of human genetics 2010 (PubMed)
    Show all 2 references for ABIN658082

  4. Human Polyclonal USP2 Primary Antibody for WB - ABIN388878 : Alonso, Magyar, Wang, Bisello, Friedman: Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 (PubMed)
    Show all 2 references for ABIN388878

  5. Human Polyclonal USP2 Primary Antibody for EIA, WB - ABIN357520 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)

More Antibodies against USP2 Interaction Partners

Human Ubiquitin Specific Peptidase 2 (USP2) interaction partners

  1. Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR (show LDLR Antibodies) by IDOL (show MYLIP Antibodies).

  2. Data suggest up-regulation of ASAH1 (acid ceramidase (show ASAH1 Antibodies)) activity by androgen in androgen-sensitive prostate cancer cells (but not other cancer cells) is mainly due to prolonged stability of ASAH1 (show ASAH1 Antibodies) by androgen-stimulated induction of USP2 expression.

  3. Modulation of USP-2 expression plays a crucial role in cell cycle regulation by leptin (show LEP Antibodies) and adiponectin (show ADIPOQ Antibodies).

  4. The present study showed that USP2 expression is associated with TNBC cell line's invasiveness and poor survival of breast cancer patients and may serve as a prognostic biomarker and therapeutic target for TNBC

  5. findings demonstrated that USP2b deubiquitinates K63-linked polyubiquitin (show UBB Antibodies) chains from TBK1 (show TBK1 Antibodies) to terminate TBK1 (show TBK1 Antibodies) activation and negatively regulate IFN-beta (show IFNB1 Antibodies) signaling and antiviral immune response.

  6. USP2 and its substrate, fatty acid synthase (FASN (show FASN Antibodies)), are over-expressed in glioma tissue.

  7. we have demonstrated that USP2a plays a negative regulatory role in IL-1beta (show IL1B Antibodies)- and SeV-induced NF-kappaB (show NFKB1 Antibodies) activation.

  8. USP2a plays an important role in TCR signaling by deSUMOylating TRAF6 (show TRAF6 Antibodies) and mediating TRAF6 (show TRAF6 Antibodies)-MALT1 (show MALT1 Antibodies) interaction

  9. USP2a antagonizes EGFR (show EGFR Antibodies) endocytosis and thus amplifies signaling activity from the receptor.

  10. TRAF2 inhibits USP2a effect on K48- but not on K63-linked ubiquitin chains.

Mouse (Murine) Ubiquitin Specific Peptidase 2 (USP2) interaction partners

  1. Usp2 is a clock output effector related to bodily Ca2 (show CA2 Antibodies)+ homeostasis, a feature that is conserved across evolution.

  2. A novel function of USP2 in the molecular clock in which it regulates PER1 (show PER1 Antibodies) function.

  3. A role for USP2-45 as a central regulator of MR, able to remove the receptor monoubiquitylation and induced its destabilization.

  4. Data suggest that USP2 does not play a primary role in the control of sodium balance or blood pressure.

  5. a functional liver clock is required for the proper nutritional and circadian regulation of USP2-45 expression; at the molecular level, transcriptional coactivators PGC-1alpha (show PPARGC1A Antibodies) and PGC-1beta (show PPARGC1B Antibodies) and repressor E4BP4 (show NFIL3 Antibodies) exert opposing effects on USP2-45 promoter activity

  6. USP2a potentially mediates circadian disruption by suppressing the CRY1 (show CRY1 Antibodies) degradation during inflammation.

  7. Rhythmic expression of USP2 in the SCN (show SRI Antibodies) and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes

  8. severe defect in the ability of Usp2 -/- spermatozoa to fertilize eggs

  9. TNFalpha (show TNF Antibodies)-induced USP2 down-regulation is an effective cytoprotective mechanism in hepatocytes.

USP2 Antigen Profile

Protein Summary

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with USP2

  • ubiquitin specific peptidase 2 (USP2) antibody
  • ubiquitin specific peptidase 2 (Usp2) antibody
  • B930035K21Rik antibody
  • UBP-t antibody
  • Ubp41 antibody
  • UBP46 antibody
  • ubp52 antibody
  • ubp66 antibody
  • USP9 antibody

Protein level used designations for USP2

41 kDa ubiquitin-specific protease , deubiquitinating enzyme 2 , ubiquitin carboxyl-terminal hydrolase 2 , ubiquitin specific protease 12 , ubiquitin specific protease 9 , ubiquitin thioesterase 2 , ubiquitin-specific-processing protease 2 , ubiquitin specific protease 2 , ubiquitin thiolesterase 2 , ubiquitin-specific-processing protease testis , family of cysteine protease , ubiquitin specific protease 41 , ubiquitin specific protease 46 , ubiquitin specific protease 52 , ubiquitin specific protease 66

GENE ID SPECIES
9099 Homo sapiens
53376 Mus musculus
115771 Rattus norvegicus
522980 Bos taurus
395766 Gallus gallus
Selected quality suppliers for anti-USP2 (USP2) Antibodies
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